ID I3KAS7_ORENI Unreviewed; 829 AA.
AC I3KAS7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 08-NOV-2023, entry version 47.
DE RecName: Full=Inter-alpha-trypsin inhibitor heavy chain 3 {ECO:0008006|Google:ProtNLM};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018222.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000018222.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR AlphaFoldDB; I3KAS7; -.
DR Ensembl; ENSONIT00000018239.2; ENSONIP00000018222.2; ENSONIG00000037382.1.
DR GeneTree; ENSGT00940000154554; -.
DR HOGENOM; CLU_008101_0_0_1; -.
DR InParanoid; I3KAS7; -.
DR OMA; INEMVIW; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF115; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..829
FT /note="Inter-alpha-trypsin inhibitor heavy chain 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025566992"
FT DOMAIN 13..142
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 268..435
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 562..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 93421 MW; 34DB9ECF9DE9E295 CRC64;
MERSVVHITL FGLLLALAST LPNKDDWDIY SFHINSTVTS RYATTVITSR VANRMNESKE
IEFHVRIPKN AFISKFRMFI DGQVYDGVVK AKEQAQQQYT EAVSRGESAG LVSSVGRTLE
EFKTSVTVAA HKKVTFELTY EELMKRTHGK YELQIHARPM QPVSDFKVDV HIHEEAGISF
INVKGDLSTK ALANAITKTH IDKEAWVYFY PTVNQQKMCD SCSDQGMNGD LVIVYDVNRD
NGLGHIKKSD GYFVHHFAPS DLPRVPKNVV FVIDQSGSMR GRKILQTRTA LFHILNDLAE
DDYFGLITFD GNIFHWKREL VQANSKNLES AKNFASNIQA RGSTDINQAL LQGARMLNDH
RREGSASILI LLTDGDPTSG YNKAHLYICD YILLLYLGIS CVFSGKMSLQ NNGVARRIYE
DSDADLQLKG FYEEVATPLL TDVTMIYVGG TNLTQTNFSQ YYNGSEIVVA GEITDNNIET
FTPQVSNRRI IFSNPNETVE STGTVSDDRI QRVWAYLTVK QLLDKELQLS GPEKEKVKKE
ALELSLKYSF VTPLTSMVVT KPPGENTDVL HKPKEGKTPQ RWQPPVDQSF SRQYLAPSIH
LSGSPIGEYH KHKKTEINEM VIWQILEKKS EYFIFTRNVL TLCTSVSLAP VLHRFLLKAE
NQTVPLCFDV SGPVRLKLLH YPSRELSVNG ELDSVTNGGF SRIFIHVSGS QHVEIDTNWV
TVRDGQTVTN YTGQDHLTAG SVTVIVRNNE IDVATGDMRM VIIVHEKNGQ KFFWPVLRQR
PLDNNAEGLL GEEMVVDYSF ASPVTMNCWL MSADSALQRP LSQFVITQL
//