ID   I3KB43_ORENI            Unreviewed;       939 AA.
AC   I3KB43;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=Catenin alpha-2 {ECO:0000256|ARBA:ARBA00023806};
DE   AltName: Full=Alpha N-catenin {ECO:0000256|ARBA:ARBA00029822};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018338.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000018338.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC       {ECO:0000256|ARBA:ARBA00004536}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004413}. Cell projection, axon
CC       {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC       {ECO:0000256|ARBA:ARBA00008376}.
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DR   AlphaFoldDB; I3KB43; -.
DR   Ensembl; ENSONIT00000018355.2; ENSONIP00000018338.2; ENSONIG00000014573.2.
DR   GeneTree; ENSGT01030000234543; -.
DR   InParanoid; I3KB43; -.
DR   OMA; QDELMNN; -.
DR   Proteomes; UP000005207; Linkage group LG6.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.250.2510; -; 1.
DR   Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR   InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR   InterPro; IPR001033; Alpha_catenin.
DR   InterPro; IPR006077; Vinculin/catenin.
DR   InterPro; IPR000633; Vinculin_CS.
DR   PANTHER; PTHR18914; ALPHA CATENIN; 1.
DR   PANTHER; PTHR18914:SF23; CATENIN ALPHA-2; 1.
DR   Pfam; PF01044; Vinculin; 1.
DR   PRINTS; PR00805; ALPHACATENIN.
DR   SUPFAM; SSF47220; alpha-catenin/vinculin-like; 4.
DR   PROSITE; PS00663; VINCULIN_1; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   REGION          898..927
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        898..917
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   939 AA;  104051 MW;  65F5DAEF0BCED502 CRC64;
     HPISHSFFTT MTTATSPILL KWDPKSLEIR TLTVERLLEP LVTQVTTLVN TSNKGPSSKK
     KGRSKKAHVL AVSVEQATQN FLEKGEQIAK DSQDLKEELI AAVEDVRKQG ETMRVASSEF
     ADDPCSSVKR GTMVRAARAL LSAVTRLLIL ADMADVMRLL AHLKIVEEAL EGVKNATNEQ
     DLANRFKEFG KEMVKLNYVA ARRQQELKDP QCRDEMAAAR GALKKNATML YTASQAFLRH
     PDVAATRANR DYVFKQVQEA IGGISSAAQA TSPTDEKHGH AGIGELAAAL NEFDNKIILD
     PLTFSEARFR PSLEERLESI ISGAALMADS SCTRDDRRER IVAECNAVRQ ALQDLLSEYM
     NNTGRKEKGD PLNSAIDKMT KKTRDLRRQL RKAVMDHISD SFLETNVPLL VLIEAAKSGN
     EKEVKEYAQV FREHANKLVE VANLACSISN NEEGVKLVRM AATQIDSLCP QVINAALTLA
     ARPQSKVAQD NMDVFKDQWE KQVRILTEAV DDITSVDDFL SVSENHILED VNKCVIALQE
     GDVDTLDRTA GAIRGRAARV VHIINAEMEN YEPGVYTERV LESIKLLSET VMPRFAEQVE
     VAIEALSMNP PQPFEENEFI DASRLVYDGV RDVRKAVLMI RTPEELEDDS DFEQEDYDTR
     SRTSVQTEDD QLIAGQSAIM AQLPQEEKAK IAEQVESFRQ EKCKLDAEVA KWDDNGNDII
     VLAKQMCMIM MEMTDFTRGK GPLKNSSDVI NAAKKIAEAG SRMDKLARAV ADQCPDSACK
     QDLLAYLQRI ALYCHQLNIC SKVKAEVQNL GGELIVSGVS CDVGGGPLAT TLKCQPNKTD
     GDRGLDSATS LIQAAKNLMN AVVLTVKASY VASTKYQKVY GTAAVNSPVV SWRMKAPEKK
     PLVKREKPEE CQTRVRRGSQ KKHISPVQAL SEFKAMDSF
//