ID I3KB71_ORENI Unreviewed; 583 AA.
AC I3KB71;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=ETS domain-containing protein Elk-1 {ECO:0000313|Ensembl:ENSONIP00000018366.2};
GN Name=LOC100703163 {ECO:0000313|Ensembl:ENSONIP00000018366.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018366.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000018366.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_013127271.1; XM_013271817.2.
DR AlphaFoldDB; I3KB71; -.
DR Ensembl; ENSONIT00000018383.2; ENSONIP00000018366.2; ENSONIG00000014594.2.
DR GeneID; 100703163; -.
DR KEGG; onl:100703163; -.
DR CTD; 2002; -.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000157571; -.
DR HOGENOM; CLU_036905_0_0_1; -.
DR InParanoid; I3KB71; -.
DR OMA; LPSRYPW; -.
DR OrthoDB; 2884081at2759; -.
DR TreeFam; TF317732; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF178; ETS DOMAIN-CONTAINING PROTEIN ELK-1; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 14..94
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 112..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..362
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 62297 MW; 46729B303E895C30 CRC64;
MESNPLINAM DPSITLWQFL LHLLEDQRQR HLISWTSEDG EFKLLDAEEV ARLWGLRKNK
HNMNYDKLSR ALRYYYDKNI IKKVSGQKFV YKFVSQPDPS LPDAIRTIEE GQRRDICDSN
NQSKSLGGVA PTCPTKGLPQ RSSPSSSQKS SRNDYMKSGL YSTFTIQSLQ ASPNPRPIKS
ELLLQQEPVP KVDRTPREGC VLPESKSSPS VGSAADSVLQ VIVTQTSPCP TPALSPQIPA
NSNGQSQNPP AAPLSDPPQI YLTNMGDPST LITLGGGTVS PVPPPHVSMG TQGPQQEDCG
GLTNPTNFPS HHPHAAPHQS HPAPVFVIIN PPPNQQQQQQ VPMTTAAPPP SVAPPPTARP
PPIVIKEENL PSEQELLEMV TLDGKQVEVV PELICDSGEP EPPPTIVESP PPPCIDAGVG
VQQPAEEERT EGEGQDTLTD PVIPPVTTSS PVTSPAASSS DAVPPKQKKP RGLELPSSPS
LPPGLSLDKV NAAVNSLLAP GSATNTLTPT VITSHALTPV LLTPSPLPST IHFWSTLSPI
APRSPAKLSF QFPSNGSNQI HIPALSVDGL STPVVLSPGP QKP
//