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Database: UniProt
Entry: I3KBJ3_ORENI
LinkDB: I3KBJ3_ORENI
Original site: I3KBJ3_ORENI 
ID   I3KBJ3_ORENI            Unreviewed;      2705 AA.
AC   I3KBJ3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 2 {ECO:0000313|Ensembl:ENSONIP00000018488};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018488, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000018488}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
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DR   EMBL; AERX01005150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01005151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01005152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000018488; -.
DR   Ensembl; ENSONIT00000018505; ENSONIP00000018488; ENSONIG00000014687.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000156039; -.
DR   InParanoid; I3KBJ3; -.
DR   OMA; ENQVKGG; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2234   2258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2270   2286       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2315   2336       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2356   2382       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2403   2425       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2528   2551       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    361       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      382    438       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2645   2686       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2705 AA;  308136 MW;  D5378DAF104D236B CRC64;
     MPEHRSSFLH IGDIVSLYAE GSVNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKV
     CPMNRYSAQK QFWKAKQGKQ GNNNTQGDLF KKLQHAAELE QKQNDSENKK LLGEVVKYSS
     VIQLLHIKSN KYLTVNKRLP ALLEKNAMRV SLDPAGNEGS WFYIQPFWKL RSEGDNVVVG
     DKVVLMPVNA GQPLHASNIE LLDNPGCKEV NAVNCNTSWK VTLFMKFSDY RDDVLKGGDV
     VRLFHAEQEK FLTCDEYKEH QYVFLRTTLR QSATSATSSK ALWEIEVVHY DPCRSGAGQW
     NSLFRFKHLA TGNYLAAEVN PEFIPKTVET KGDVNQNETD IVYSKKKNQA AERIAFTLVS
     VPHGNDISSL FELDATTLQR ADCLVPRNSY VRLRHLCTNT WVTSTNVPID ADEERPVMLK
     IGTCSTKEDK EAFAIVSVPL SEVRDLDFAN DANKVLESTV KKFSNSSISQ NERRFVTKLL
     EDLVYFVCVV PNNGEDVLSV VTSTPNRERQ KLMREQNILA QIFGILKAPF TDSRDGPMLR
     LEELGDQRYA HYKYMFSLCY RILRHSQQDY RKNQEYIAKK FTIMQSQIGY EILAEDTITA
     LVHNNRKLLE KHITAREIET FVNLLRRNRE PRFLDYLSDL CVSNKTAIPI TQELICKFML
     NPSNADILIQ TKLISNIETS NLESSLMQEE GEEEEVWLYW IDSNKEPHGK SIRHMAQDAK
     ASHKCDAEII TYYRYQLNLF AKMCLDRQYL AINQISSQLS VDLLLRCMYD DCLPYNLRAS
     FCRLMLHMHV DRDPQESVVP VRYARLWTEI PSKINVNEFE YESTDSSTEE MKKKFAPTME
     FVEEYLKDVL NQAHPFEEKA KNELTLEVVN LARNLVYFGF YSFSELLRLT RTLLSILDFV
     QYPASPLNKL SKGPEAGGNN VLRTIHGVGE MMTQMVMSRG VPHILPDSPP SLRYGKVLFL
     PENEDLMVMD TKLKIIEILQ FILSVRLDYR ITYLLSIYKK AFGDRALTDS SMSLADMPPM
     TLLSSACEPD IDEIVQKAES MFVESSELSA VELDGEDGRT FLRVLIYLIM QDYPPLVSGS
     LQLLFKHFSQ RSEVLEAFKQ VQLLVSEQDV ENYKQIKADL DQLRLTVEKS ELWVEKSVVY
     TGEELAAKMA KEPNAEEAVL SPVQDGENKP QIDSNKANNY NIIKEILLRL SKLCYGNKKS
     RVQQQRLLKN MGAHTVVLDL LQIPYEKSDD KMNDIMTLAH TFLQNFCKGN HQNQVLLHKQ
     LNLFLTPGLL EAETMRQIFM NNYQLCNEIS DRVVHHFVHC IETHGRHVQY LRFLQTIVKA
     DTKYVKKCQD KVMTELVNAG EDVLVFYNDR SSFQVLLQMM GSERERGDEY GALAYHNTLV
     ELLAACTEGK NVYTELKCNS LLPLDDIVKV VTDVTCIPEV KTAYVNFVNH CYVDTEVEMK
     EIYTSSHIWK LFDNFLVDMA SVCNTTTERS HADLALEKYV TETVMAIVKG FFSSPFSVNH
     SNLQTNQSIF IKLLQSAFRI YNCTWPSSAQ KANIESCIKT LADVAKARSI AIPVDLDSQV
     NTLSLKVHSN MVQRAAKDWR ISARTRPRKE PLGGPDYKNI IEKLQGVVSH LEEQFSPKVQ
     AEFSVLVDVL HSPELLFPEP ARLRCEGGAF MSKLIKHTKK LMDKEDKLCL KILETLREML
     EKKESFEQSG NDLRKILLTR YFGNQKLLSK SELGSGNSSS GGFVKQSPGG GSPMVDADKP
     ATSVSDIQCL LDNVGATEMV IELIVNTKND RLFTESIELG IALLRGGNTQ IQNSFYSQLN
     KQKKSERFFK VFYDRMRLAQ QEIRATVSVN MFEVSCRKRD DDSDVSSIRV KKGKDSGLHM
     RDDMRGQLKE ASSVTSKAFS AFRKELDPDL EGLGQNSEII GTEEALEDTQ MSPAVSIMKP
     ILRYLQLLCE NHNSKLQNFL RSQNNKTNYN LVCETLQFLD CICGSTTGGL GLLGLYINEF
     NVDLILQTLE TITEYCQGPC HENQSCIAKH ESNGIDIIIA LIVNAINPLG KDRLDLVLQL
     KNNASKLLLA IMESCHDSEN AEKILYKMRP TELVDVMKDA YKQGLQSEDD DDGMGDEIKP
     KDVGHNIYIL AHQLARHNKI LQQSLTPGSG LGLGSGMDHD KEKDDALRYY AKHTAQIEIV
     RNDRSMEQIV FPVPNICEYL TEESKMRVFT TTERDDQGSK VNDFFHQFDN LYNEMRWQKK
     IRKNKALFWF SRHISLWGSI SFYLALLLNI AVAVFYPFGD DEDEGTLSPF WNILLWVALG
     VFTALLPVLP KPIGIGFFLV SLILRAIYTM GLGPALLLLG AVNLFNKLVF LVSFVGNQGT
     FTRGYKAVVM DMLFIYHLWY AIICVLGLFV HEFFYSFLLF DLVIREETLL NVIKSVTRNG
     RSIFLTAVLA VFLVYFFSII GFLFLKDDFR MEVDRLPSPV LVGKRDLLSN SEVAGSCLKD
     RCPASTPTSV PVGGGDEDDG TERVCDTLLM CIITVLNQGL RNGGGVGDIL RRPSKEEPLF
     AARVVYDLLF FFVVIIIVLN LIFGVIIDTF ADLRSEKQRK EEILKTSCFI CGLERDKFDN
     KTVSFEEHIK SEHNMWHYLY FMVLVRVKDP TEYTGPESYV NKMIAEKNLD WFPRMRAMSL
     VSSEGDNEQN EMRSLQEKLE NTANLVAQLS GQLAELKEQM TEQRKNKQRL GFLGPPQPNH
     HIPTH
//
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