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Database: UniProt
Entry: I3KBW1_ORENI
LinkDB: I3KBW1_ORENI
Original site: I3KBW1_ORENI 
ID   I3KBW1_ORENI            Unreviewed;       510 AA.
AC   I3KBW1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   24-JAN-2024, entry version 65.
DE   RecName: Full=Coatomer subunit delta {ECO:0000256|ARBA:ARBA00018359, ECO:0000256|RuleBase:RU364018};
GN   Name=arcn1 {ECO:0000313|Ensembl:ENSONIP00000018606.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018606.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000018606.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC       dilysine motifs and reversibly associates with Golgi non-clathrin-
CC       coated vesicles, which further mediate biosynthetic protein transport
CC       from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC       complex is required for budding from Golgi membranes, and is essential
CC       for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
CC       {ECO:0000256|RuleBase:RU364018}.
CC   -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC       beta', gamma, delta, epsilon and zeta subunits.
CC       {ECO:0000256|ARBA:ARBA00011775, ECO:0000256|RuleBase:RU364018}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU364018,
CC       ECO:0000256|RuleBase:RU366052}. Cytoplasmic vesicle, COPI-coated
CC       vesicle membrane {ECO:0000256|RuleBase:RU364018,
CC       ECO:0000256|RuleBase:RU366052}; Peripheral membrane protein
CC       {ECO:0000256|RuleBase:RU364018, ECO:0000256|RuleBase:RU366052};
CC       Cytoplasmic side {ECO:0000256|RuleBase:RU364018,
CC       ECO:0000256|RuleBase:RU366052}. Golgi apparatus membrane
CC       {ECO:0000256|RuleBase:RU364018, ECO:0000256|RuleBase:RU366052};
CC       Peripheral membrane protein {ECO:0000256|RuleBase:RU364018,
CC       ECO:0000256|RuleBase:RU366052}; Cytoplasmic side
CC       {ECO:0000256|RuleBase:RU364018, ECO:0000256|RuleBase:RU366052}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC       Delta-COP subfamily. {ECO:0000256|ARBA:ARBA00010516,
CC       ECO:0000256|RuleBase:RU364018}.
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DR   RefSeq; XP_005462494.1; XM_005462437.3.
DR   AlphaFoldDB; I3KBW1; -.
DR   STRING; 8128.ENSONIP00000030153; -.
DR   Ensembl; ENSONIT00000018623.2; ENSONIP00000018606.1; ENSONIG00000014779.2.
DR   GeneID; 100700142; -.
DR   KEGG; onl:100700142; -.
DR   CTD; 399661; -.
DR   eggNOG; KOG2635; Eukaryota.
DR   GeneTree; ENSGT00390000017207; -.
DR   HOGENOM; CLU_019988_3_0_1; -.
DR   OrthoDB; 205756at2759; -.
DR   TreeFam; TF105760; -.
DR   Proteomes; UP000005207; Linkage group LG14.
DR   GO; GO:0030126; C:COPI vesicle coat; IEA:UniProtKB-UniRule.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:UniProtKB-UniRule.
DR   CDD; cd09254; AP_delta-COPI_MHD; 1.
DR   CDD; cd14830; Delta_COP_N; 1.
DR   Gene3D; 3.30.450.60; -; 1.
DR   Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR   InterPro; IPR036168; AP2_Mu_C_sf.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR027059; Coatomer_dsu.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR028565; MHD.
DR   PANTHER; PTHR10121; COATOMER SUBUNIT DELTA; 1.
DR   PANTHER; PTHR10121:SF0; COATOMER SUBUNIT DELTA; 1.
DR   Pfam; PF00928; Adap_comp_sub; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR   SUPFAM; SSF64356; SNARE-like; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU364018};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW   ECO:0000256|RuleBase:RU364018};
KW   ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW   ECO:0000256|RuleBase:RU364018};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW   ECO:0000256|RuleBase:RU364018}; Membrane {ECO:0000256|RuleBase:RU364018};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU364018};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU364018}.
FT   DOMAIN          270..510
FT                   /note="MHD"
FT                   /evidence="ECO:0000259|PROSITE:PS51072"
FT   COILED          147..179
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   510 AA;  56812 MW;  3EC96A03D26AF52E CRC64;
     MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE TDSVRYVYQP
     LEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRVLEES EISEHCFDLI FAFDEIVALG
     YRENVNLAQI RTFTEMDSHE EKVFRAVRET QEREAKAEMR RKAKELQQAR RDAERSGKKV
     PAFGGFGSAG MTSVSSGTII TDTIVEPEKP KITAAPVRPS GPSKALKLGA KGKEVDNFVD
     KLKSEGETIM PTTGKRGSDV SKVLPPPVNM ESVHLRVEEK ITLTCGRDGG LQNMEVLGMV
     TLRVTDDKYG RIRLIINNND GKGLQLQTHP NVDKKLFTAE SVIGLKNPEK SFPLNNDVGV
     LKWRLQTTDE SLIPLTINCW PSESGTGCDV NIEYELQEEN LELNDVVISI PVPSGVGAPV
     IGDLDGEYKH DSRRNILEWC LPVIDANNKT GSLEFSIAGQ PNDFFPISVS FVSKRNYCDI
     QVTKVTHVDG DSSIRFSSET SFVVDKYEIL
//
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