ID I3KC48_ORENI Unreviewed; 1412 AA.
AC I3KC48;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Nuclear factor of activated T cells 5a {ECO:0000313|Ensembl:ENSONIP00000018693.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018693.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000018693.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8128.ENSONIP00000018693; -.
DR Ensembl; ENSONIT00000018710.2; ENSONIP00000018693.2; ENSONIG00000014846.2.
DR eggNOG; ENOG502QSVE; Eukaryota.
DR GeneTree; ENSGT00940000155213; -.
DR InParanoid; I3KC48; -.
DR OMA; LPMGQQS; -.
DR TreeFam; TF326480; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd07882; RHD-n_TonEBP; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR015646; NFAT5_RHD_DNA-bd.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF10; NUCLEAR FACTOR OF ACTIVATED T-CELLS 5; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 291..460
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 32..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 825..906
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 930..961
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 35..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1412 AA; 152474 MW; D9EBFAC5E4E5577B CRC64;
MPSDFISLLS SDIDLNSPKS LYSKESVYDL LPKELQLQPS STQTDPPTMS QNSGGEAGPP
PLQPWHATSS TSSPSASSSL AIGVTSSGPS TSSSDHLKVA QHLHSSGGDG AGVSEMQGAE
GAPSRGSSGA NATVGDVGPG GLPGLGVQQP QNTPSKRRTV LSISPPPEDL FDDSQMSCQE
EPTISGAPGP DSEQSSSMWA DDSVSNFSLI SSISYNDNTE VPRKSRKRTP RQRPGPKPAP
PEDSMDVFDA DSAKAPHYVL SQLGTDKTSS ISSSLESGTA VKGGSLSAQF PQRSDGKELK
ILVQPETQHR ARYLTEGSRG SVKDRTQQGF PTVKLEGVSD SVVLQVFVAN DAGRVKPHGF
YQACRVTGRN TTACKEVDIE GTTVIEIPLE PSNDMTLAVD CVGILKLRNA DVEARIGVAG
SKKKSTRARL AFRVNIPQPD GSTLTLQVPS SPILCTQPAG VPEILRKSLH SCSVKGGEEV
FIIGKNFLKG TKVIFQENIT DDNSWQAEAK IDMDLFHQNH LIVTVPPFHN QSITSPVSVG
IFVMTNAGRS HEAQPFTYTP DSADNSNVLT VKTEGISMVK TCLFDTPIKS MPSEQTEISD
QTSKRQEDTP MEVSSNPPST EVFKSSPDPL ITVQQTLDLG SSPHPGGESF QRTMPLPSED
VDLPQAPPVF PSLESLSTIQ KQEIAPTTSF SVSGDTTIPP VTPEVPQQFL RDPQESLSPE
SSSSSAGVVV VAMPQIAPSS QAQPQQSQVS LFPQEEVAQL ERAVRELQGG SNTTLQQVLE
AAVAQQQLNS VLYSPTPSAD SLQQHVQENM NSLRLGSTDN SLSAQQQLQI QQQEQQQQIQ
QQFQQQQMQQ QQQILGNLQQ QQQQVINNIQ MQQQLILQPQ EQQQIMENIQ QQQQQLQQNQ
QQQVLNNIQL QDQQQQNHIL TNLQQHQLQQ QQQQQQQNQA LSNLQQQQQQ LQEQQVLENL
QQHLQASSLL QQAGELLTIQ TSFPTQPPSH TSPPQQLFQS PRPMAETQGS QQQVQAALIQ
NTLTVLTSGS LNSEPQSTGS TLYLTPNHQP QPQPQQQQQL AFLSSMETSA SQPQSVSMFQ
NQPQSQMQQQ STPMDQQQSP QQNQQQSAQL PMGQQGSLFQ SIPNHSQGNP APQQTGLLLC
TTDLNPQAIA PTILFSTQTQ GPSPMGTISV GITQSDTAEP MSFQDQSSSG SNSTTTENQQ
QSLFQEQQPM QVGPSSSSVQ NNQPVELFIP QTNLSSLQST IGSQDLNNQA PAPATTIFVV
QGGVGVVASP GQQPPEQLFQ TSVGGNVASQ GQASLFVFGI QNDSSQLLTS SGPSQPAQNQ
IQNSGHMQTL LDQPMAQAAQ MQTTLENAMQ ANTQTALQSS LQGNIEASLP TPMQTSLQTQ
IQSSLQNQLQ ASISTSSSMD KIEDLLESLQ KQ
//
