ID   I3KCC5_ORENI            Unreviewed;       748 AA.
AC   I3KCC5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=FERM domain containing 4A {ECO:0000313|Ensembl:ENSONIP00000018770.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018770.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000018770.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_019217079.1; XM_019361534.1.
DR   RefSeq; XP_019217080.1; XM_019361535.1.
DR   AlphaFoldDB; I3KCC5; -.
DR   Ensembl; ENSONIT00000018787.2; ENSONIP00000018770.2; ENSONIG00000014909.2.
DR   GeneTree; ENSGT01020000230354; -.
DR   HOGENOM; CLU_003623_2_0_1; -.
DR   Proteomes; UP000005207; Linkage group LG7.
DR   GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR   InterPro; IPR021774; CUPID.
DR   InterPro; IPR047176; FRMD4A/B.
DR   PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR   PANTHER; PTHR46079:SF3; FERM DOMAIN-CONTAINING PROTEIN 4A; 1.
DR   Pfam; PF11819; CUPID; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          48..181
FT                   /note="Cytohesin Ubiquitin Protein Inducing"
FT                   /evidence="ECO:0000259|Pfam:PF11819"
FT   REGION          56..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          243..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          590..625
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          638..707
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..75
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..278
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..301
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        327..380
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        392..406
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..474
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..503
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        639..667
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..707
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   748 AA;  80687 MW;  65D51CF06E63B229 CRC64;
     MAISQHQFYL DRKQSKSKIH AARSLSEIAI DLTETGTLKT SKLANMGSKG KIISGSSGSL
     LSSGSQESDS SQTAKKDMLA ALRARQEALE ETLKQRLEEL KSICIREAEL TGKLPKEYPL
     DPGEEPPTVR RKIGTAFKLD EQKILPKGEE EELERLEREF AIQSQITEAA RRLASDPHVS
     SKKLKKQRKT SYLNALKKLQ EIENSINEYR VRSGKKPTQR ASLIIEEANI GSEDSSLSDA
     LVLDDDDPQV TGTPTFSPVA SPHKGLPPRP PSHSRPPPPQ SLDGLRHLHY TRSDYDKSPI
     KPKMWSESSL DEPYEKVKKR SSHSSHRRFP SSGSAEAGGS NSLQSSPIRS LPHWNSQSSM
     PSTPDLRTRT PHYVHSTRSV DISPTRLHSL SQHFRNRSSS LESQGKLLAS DPDAHPHTLG
     SPDFFLGPGR SSNGSDPLDD CSSCTSQSSS EHYYPSGGPP GSNPNYSTLG EDSPSKARQR
     QRQRHRSAGH LGSSNSGSMP NLAAKNGSGG GLGGSGVGGG HHGVYLHSQS QPSSQYRIKE
     YPLYVEGSPN PVVVRSLESD QEGHYSVKAQ FKTSSSYTAG GLYKEAWGAE EGGEGSGRLT
     PSRSQIVRTP SLGREGGGGG GGGRAAVSEE LRCWYQRSSG SLKERSHSHS GSTSSETGSQ
     QGTLGHGRGS RVGTLAKGSP AASPHSQRSM TPSSEHTATP TPPCSPQHIL NWQSGTLSDS
     CFLSSPLCSE LADVQWYGQD KAKPGTLV
//