ID I3KCI3_ORENI Unreviewed; 2541 AA.
AC I3KCI3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Nipped-B protein {ECO:0000256|RuleBase:RU364107};
GN Name=nipbl {ECO:0000313|Ensembl:ENSONIP00000018828.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018828.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000018828.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364107}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}.
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DR RefSeq; XP_013127317.1; XM_013271863.2.
DR RefSeq; XP_013127318.1; XM_013271864.2.
DR Ensembl; ENSONIT00000018845.2; ENSONIP00000018828.2; ENSONIG00000014956.2.
DR GeneID; 100691634; -.
DR KEGG; onl:100691634; -.
DR CTD; 570900; -.
DR eggNOG; KOG1020; Eukaryota.
DR GeneTree; ENSGT00390000010427; -.
DR HOGENOM; CLU_000763_0_0_1; -.
DR InParanoid; I3KCI3; -.
DR OMA; KQNENRM; -.
DR OrthoDB; 1409889at2759; -.
DR TreeFam; TF313121; -.
DR Proteomes; UP000005207; Linkage group LG12.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107}.
FT DOMAIN 1973..2153
FT /note="Sister chromatid cohesion C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12830"
FT REGION 132..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1386..1406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2180..2249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2388..2439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..300
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..861
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..890
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2180..2210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2219..2238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2417..2434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2541 AA; 284936 MW; 95A986012D84FB7B CRC64;
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LYNGRIAEEV TCLLGCRDEN
LASQLAHGLN QVSTEHIELK DNLGSDEPEG DAPLLLQTML ARNPGIFREK NVMQQPMVQP
FKINSMHSPA QSANFQPAAI SPNPPSRFVT PPTGSSSRYM GQQNSPVPSP YTPQSPATGY
IQQYPHQQPP SYNQHQQIQQ VSVASPMVPG GIRNIHEGKV TGQIPNAANH HSDRHGTEDY
LNIVHRLGNE EGDSAMRNPS FPLRSPQSGC SPASSEGTPK PGSRPPLILQ SPPPYAPSPR
EGVPDQKQQL QQRKKVPIVK EEKDMYDIVS SPSKDSTKLT LKLSRVKSNE SDPPGDVMPG
MDQNSDNMEA ELGFQQVPVL QQNLGARLQH QQQVGGASGL QPPSSPYDEA ELDALAEIER
IEREAASEKC SKEVQDKDKP LKKRKQDSFP LEPGAGGPGG PTGAPGSGST GGGNAGKLTP
QEATAAGNGA SRPPLMVSID LQQAGRADGQ LDPCLAAPVP ALEAQRWPEE PASGPAAVEG
SDTVLRLKPD GRPEVIKNRV DKHDSRREGR ESSKHRHDEK SSDRRGELPK SSNRDRESDR
DRRHRSETGR DRRSPDSRSR SDRDRSGFRA SSTGEPGRSS SRQDGSKLPS SASGAKLPDS
FPAQLLGGHS GALKNFQIPK INRDKEGSGS TESQMWGQPK VKLERLGLVQ DLEKRPKPVV
VLKKLSVDQI QRIIRHSKSG KNRLSSGKSG KSGMDPAVLK ELPPELLAEI ESTMPLCERV
KMNKRKRSTV NERPKYAEVS SDEDYDATGE SARKRQRREK DRAWEFEERE RRGSGEHRKS
GHRDSRRGSG SRYRDSSEED SPPPSMSEVA RKMKMKEKQK KRKAYEPKLT QEELMDSSTF
KRFLASIDNI LENLEDVDFT TMAGDDDEIP QELLLGKHQL NELGSESAKI KAMGISSRIP
SDKLVKLLNI LEKNIQDGSK LSTMMNHDHD AEDEERLWRD LIMERVTKSA DACLTALNIM
TSAHMPKAVY IEDVIERVLQ YTKFHLQNTL YPQYDPVYRV DPHGGGMLSS KAKRAKCSTH
KQRVIVMLYN KVCDIVSNIS ELLEIQLLTD TTILQVSSMG ITPFFVENVS ELQLCAIKLV
TAVFSRYEKH RQLILEEIFT SLARLPTSKR SLRNFRLNSS DQDGEPMYIQ MVTALVLQLI
QCVVHLPSDK DVFEEYDTKV DQDVLITNSY ETAMRTAQNF LSVFLKKCGS KQGEEDYRPL
FENFVQDLLS TVNKPEWPAA ELLLSLLGRL LVHQFSNKQT EMALRVASLD YLGTVAARLR
KDAVTSKMDQ RSIDRIVQES QGSDETQQLQ KALLDYLEEN AETDASLVFA RKFYIAQWFR
DATTEAEKSM RNQNPKDEDS SDGPQHAKEV EATGEIMQRA EKRKKFLRNI IKTTPAHFTT
LKMNSDTVDY EDACLIVRYL ASMRPFAQSF DIYLTQILRV LGESAIAVRT KAMKCLSEVV
AVDPSILARS DMQRGVHGRL MDNSTSVREA AVELLGKFVL SRPQLTEQYY DMLIERILDT
GISVRKRVIK ILRDICLEQP TFSKITEMCV KMIRRVNDEE GIKKLVNETF QKLWFTPTPA
HDKETMTRKI LNITDVVAAC RDTGYDWFEQ LLQNLLKSEE DASYKPAEKA CVQLVDNLVE
HILKYEESLA ENKGVNSTRL VACITTLYLF SKISAQLMVK HAMTMQPYLT TKCNTANDFM
VICNVAKILE LVVPLMEHPS ATFLATIEED LMKLIIKYGM TVVQHCVSCL GAVVNKVTHN
YKFVWACFNR FYGALNRLKV QHQEDPNDTK LVANKPFLLR SLFTVGALAR HFDFDLEEFK
GTTKVVIKEK VLELLLYFTK HEDEEVKTKA IIGLGFLVIM HPSQMFVPEV KSLYNGILAD
SGSSINLKIQ ILKNLQTYLQ EEDTRMQEAD REWKKMSKQE DLKEMGDISS GMSSSIMQLY
LKQVLEAFFH TQSSVRHFAL NVIALTLNQG LIHPVQCVPY LIAMGTDPEP SMRNKADQQL
VEIDKKYTGF IHMKAVAGMK MSYSLQQAIN SSRKSIIRGF RQDETHSALC SHLFTMIRGN
RQHRRAFLIS LLNLFDDSAK TDVNMLLFIA DNLACFPYQS QEEPLFIMHH IDITLSVSGS
NLLQTFKELL LKEPRRKEKK VKKEWKNTSD GEDDEEKMNC DSWRSEDAEN SNGEDNEDND
EDVVRRPKKT KKPVANSESS ESESDLDDLD VDDVEKVMRL LPDNPTGLLD FANAVQGILL
LLVLKQHLKN QYGFSDSKIQ KYSPTESAKV YDKAVNRKGN IHFHPRQTID FISNNMAHAT
LTDGVKKQIV KQYLDFKVLM EHLDPDEEDE EGEASASANI RNKAINALLG GSGPLSGPSP
RNQAGPETDD DDSDGDERTP GSSRKSRRAG DSSDPGRMSE TVEVMDVIAL CCPKYKDRPQ
IARVIQKTSN GYSIHWMAGS YSGPWAEAKK RDGRKLVPWV DTIKESDIIY KKIALTSNHK
LSNKVVQTLR SLYAAREGGA S
//
