ID I3KCI4_ORENI Unreviewed; 2510 AA.
AC I3KCI4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Nipped-B protein {ECO:0000256|RuleBase:RU364107};
GN Name=nipbl {ECO:0000313|Ensembl:ENSONIP00000018829.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018829.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000018829.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364107}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}.
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DR STRING; 8128.ENSONIP00000018828; -.
DR Ensembl; ENSONIT00000018846.2; ENSONIP00000018829.2; ENSONIG00000014956.2.
DR GeneTree; ENSGT00390000010427; -.
DR Proteomes; UP000005207; Linkage group LG12.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107}.
FT DOMAIN 1942..2122
FT /note="Sister chromatid cohesion C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12830"
FT REGION 132..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1367..1387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2149..2218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2357..2408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..300
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..844
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2149..2179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2188..2207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2386..2403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2510 AA; 281557 MW; 924BB355D6A640E3 CRC64;
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LYNGRIAEEV TCLLGCRDEN
LASQLAHGLN QVSTEHIELK DNLGSDEPEG DAPLLLQTML ARNPGIFREK NVMQQPMVQP
FKINSMHSPA QSANFQPAAI SPNPPSRFVT PPTGSSSRYM GQQNSPVPSP YTPQSPATGY
IQQYPHQQPP SYNQHQQIQQ VSVASPMVPG GIRNIHEGKV TGQIPNAANH HSDRHGTEDY
LNIVHRLGNE EGDSAMRNPS FPLRSPQSGC SPASSEGTPK PGSRPPLILQ SPPPYAPSPR
EGVPDQKQQL QQRKKVPIVK EEKDMYDIVS SPSKDSTKLT LKLSRVKSNE SDPPGKINAD
EVHCDNSDNM EAELGFQQVP VLQQNLGARL QHQQQVGGAS GLQPPSSPYD EAELDALAEI
ERIEREAASE KCSKEVQDKD KPLKKRKQDS FPLEPGAGGP GGPTGAPGSG STGGGNAGKL
TPQEATAAGN GASRPPLMVS IDLQQAGRAD GQLDPCLAAP VPALEAQRWP EEPASGPAAV
EGSDTVLRLK PDGRPEVIKN RVDKHDSRRE GRESSKHRHD EKSSDRRGEL PKSSNRDRES
DRDRRHRSET GRDRRSPDSR SRSDRDRSGF RASSTGEPGR SSSRQDGSKL PSSASGAKLP
DSFPAQLLGG HSGALKNFQI PKINRDKEGS GSTESQMWGQ PKVKLERLGL VQDLEKRPKP
VVVLKKLSVD QIQRIIRHSK SGKNRLSSGK SEIESTMPLC ERVKMNKRKR STVNERPKYA
EVSSDEDYDA TGESARKRQR REKDRAWEFE ERERRGSGEH RKSGHRDSRR GSGSRYRDSS
EEDSPPPSMS EVARKMKMKE KQKKRKAYEP KLTQEELMDS STFKRFLASI DNILENLEDV
DFTTMDDDEI PQELLLGKHQ LNELGSESAK IKAMGISSRI PSDKLVKLLN ILEKNIQDGS
KLSTMMNHDH DAEDEERLWR DLIMERVTKS ADACLTALNI MTSAHMPKAV YIEDVIERVL
QYTKFHLQNT LYPQYDPVYR VDPHGGGMLS SKAKRAKCST HKQRVIVMLY NKVCDIVSNI
SELLEIQLLT DTTILQVSSM GITPFFVENV SELQLCAIKL VTAVFSRYEK HRQLILEEIF
TSLARLPTSK RSLRNFRLNS SDQDGEPMYI QMVTALVLQL IQCVVHLPSD KDVFEEYDTK
VDQDVLITNS YETAMRTAQN FLSVFLKKCG SKQGEEDYRP LFENFVQDLL STVNKPEWPA
AELLLSLLGR LLVHQFSNKQ TEMALRVASL DYLGTVAARL RKDAVTSKMD QRSIDRIVQE
SQGSDETQQL QKALLDYLEE NAETDASLVF ARKFYIAQWF RDATTEAEKS MRNQNPKDED
SSDGPQHAKE VEATGEIMQR AEKRKKFLRN IIKTTPAHFT TLKCVTANLI SIPPPGIQTF
FVLYQILRVL GESAIAVRTK AMKCLSEVVA VDPSILARSD MQRGVHGRLM DNSTSVREAA
VELLGKFVLS RPQLTEQYYD MLIERILDTG ISVRKRVIKI LRDICLEQPT FSKITEMCVK
MIRRVNDEEG IKKLVNETFQ KLWFTPTPAH DKETMTRKIL NITDVVAACR DTGYDWFEQL
LQNLLKSEED ASYKPAEKAC VQLVDNLVEH ILKYEESLAE NKGVNSTRLV ACITTLYLFS
KISAQLMVKH AMTMQPYLTT KCNTANDFMV ICNVAKILEL VVPLMEHPSA TFLATIEEDL
MKLIIKYGMT VVQHCVSCLG AVVNKVTHNY KFVWACFNRF YGALNRLKVQ HQEDPNDTKL
VANKPFLLRS LFTVGALARH FDFDLEEFKG TTKVVIKEKV LELLLYFTKH EDEEVKTKAI
IGLGFLVIMH PSQMFVPEVK SLYNGILADS GSSINLKIQI LKNLQTYLQE EDTRMQEADR
EWKKMSKQED LKEMGDISSG MSSSIMQLYL KQVLEAFFHT QSSVRHFALN VIALTLNQGL
IHPVQCVPYL IAMGTDPEPS MRNKADQQLV EIDKKYTGFI HMKAVAGMKM SYSLQQAINS
SRKSIIRGFR QDETHSALCS HLFTMIRGNR QHRRAFLISL LNLFDDSAKT DVNMLLFIAD
NLACFPYQSQ EEPLFIMHHI DITLSVSGSN LLQTFKELLL KEPRRKEKKV KKEWKNTSDG
EDDEEKMNCD SWRSEDAENS NGEDNEDNDE DVVRRPKKTK KPVANSESSE SESDLDDLDV
DDVEKVMRLL PDNPTGLLDF ANAVQGILLL LVLKQHLKNQ YGFSDSKIQK YSPTESAKVY
DKAVNRKGNI HFHPRQTIDF ISNNMAHATL TDGVKKQIVK QYLDFKVLME HLDPDEEDEE
GEASASANIR NKAINALLGG SGPLSGPSPR NQAGPETDDD DSDGDERTPG SSRKSRRAGD
SSDPGRMSET VEVMDVIALC CPKYKDRPQI ARVIQKTSNG YSIHWMAGSY SGPWAEAKKR
DGRKLVPWVD TIKESDIIYK KIALTSNHKL SNKVVQTLRS LYAAREGGAS
//
