ID   I3KCM9_ORENI            Unreviewed;      1224 AA.
AC   I3KCM9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Astrotactin 2 {ECO:0000313|Ensembl:ENSONIP00000018874.2};
GN   Name=ASTN2 {ECO:0000313|Ensembl:ENSONIP00000018874.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018874.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000018874.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3KCM9; -.
DR   Ensembl; ENSONIT00000018891.2; ENSONIP00000018874.2; ENSONIG00000014991.2.
DR   GeneTree; ENSGT00390000003140; -.
DR   HOGENOM; CLU_006316_1_0_1; -.
DR   Proteomes; UP000005207; Linkage group LG7.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001764; P:neuron migration; IEA:InterPro.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   InterPro; IPR040685; Annexin-like.
DR   InterPro; IPR045574; ASTN1_2_Fn3.
DR   InterPro; IPR045575; ASTN_1_2_N.
DR   InterPro; IPR040510; ASTN_2_hairpin.
DR   InterPro; IPR026995; Astrotactin.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR020864; MACPF.
DR   PANTHER; PTHR16592; -; 1.
DR   PANTHER; PTHR16592:SF2; ASTROTACTIN-2; 1.
DR   Pfam; PF18411; Annexin_2; 1.
DR   Pfam; PF19743; ASTN1_2_fn3; 1.
DR   Pfam; PF19441; ASTN_1_2_N; 2.
DR   Pfam; PF18577; ASTN_2_hairpin; 1.
DR   SMART; SM00457; MACPF; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        139..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        316..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          736..917
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|SMART:SM00457"
SQ   SEQUENCE   1224 AA;  136981 MW;  DCBD9D532277DE2A CRC64;
     ISLCGECTLG FNRNLSGQLD TETPCEVKTV TVSTLPVLRE NEFSFTGGGG ESRLLLFVRT
     DLPGRISVMD DLDNTALPYF TLEMSGTGEE ISQVHWKQQW LENGTLYFHV SMTESELLAQ
     TTQPTAREPA HVLHEHMHLL HISVMGGLIA LLLLILLFTL VLYTRHRWCK RRRIPQKSAS
     TEATHEIHYI PSVLLGPQGR DSYRGSRSTH QHGSSVIGMP IRETPILDDY DCDDEVDAGG
     HSLNSTPNQI HNKLSDGKVL DDYGVGIQGH PDMMSAGGVF GPQGESGSEP EDDNQMKFYT
     EQHRGRRRSK GHPHSPLNKV TLTLITISTC VIAIVYATQD SCPLTVKVTL HVPEHFVADG
     SSFVVSMGSF LDVSNWLNPA KLTLYYQTNS STQWVQDYCG QRTTEPCEQI CDQDTGECSC
     HEGYSPDPVH KHLCVRSDWS RNEGPWPYAN LEKGYDLVTG EQAPERIFRS FYSLGQGLWL
     PVSKSFVVPP VELSINPIAS CKTDVLVTED PGEIREEAMM STYFENVEDL LASFGPARDC
     SKDNGGCKKN FKCVSDRQLD SSGCMCPEGL RPMKDGSGCY DYSRGIDCTD GFNGGCEQLC
     LQQLVPLEDD PSSSNVLMFC GCVQEYKLAG DGRSCLLQSD NCDGPKCPKQ DVYFNDTLFG
     EMLHGYNNKT QQVNLGQIFQ MTFRDNNFIK DFPQLADGLM VIPLPVEEQC RGVLSEPLPN
     LQLLTGDAQF SEAVGYPMVQ QWRVRSNLYK VKLSSITLST RDELLAFLQQ YGSHYVSEAL
     YGSELSCSIY FPSKKAQQQL WLQYQKEHFC FVHNGNSSGI GGGGRRELKS LPFISYLSAL
     QKSQLLSDDM VNGVEIRCEE KGSCPAGCHL CHHQAMMGGP SPIPVLLEVS RVVPLYSLVQ
     DNITKEALKS ATMSSYWCAG KGDVIDNWCR CDLSAFSKDG LPNCSPLRQP ILRLSPYLEP
     SSTMVALEWM DVEPLIGCKV SDYIIQHKRV EDPSEAEIYT GEVLSLMDDL FSGLGSSCVV
     AGRRSGDHPH SVLYSVVFKC LEPDSLYKFT LYAVDSRGSY SESSFVSVRT SCPVVDDTRA
     EETADKVYNL YNGYTSGKEQ QMAYNLLMEI PPPLLYRVQH HYNSHYEKFG DFVWRSEDEL
     GPRKANLILR RVEKISLYCR SLLRSTHIQS RTDTMAYVYC RSEEARPPTN MWHGSLHDSR
     TACMEKLISV QRNTYKEKKE ISIV
//