ID   I3KD17_ORENI            Unreviewed;       860 AA.
AC   I3KD17;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO2 {ECO:0000313|Ensembl:ENSONIP00000019012.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000019012.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000019012.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; I3KD17; -.
DR   Ensembl; ENSONIT00000019029.2; ENSONIP00000019012.2; ENSONIG00000015108.2.
DR   eggNOG; KOG2514; Eukaryota.
DR   GeneTree; ENSGT00940000155840; -.
DR   HOGENOM; CLU_006685_1_2_1; -.
DR   TreeFam; TF314265; -.
DR   Proteomes; UP000005207; Linkage group LG7.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF20; ANOCTAMIN-2; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        215..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        291..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        366..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        412..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        454..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        579..601
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        735..756
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          37..169
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          205..770
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          86..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          537..556
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   860 AA;  97609 MW;  2A3255218BA38CA8 CRC64;
     MPLTTAMSES SSFHSQKLIS LARSLSGLGL DLGPGLFFAD GKRKVDYVLC YKYKKRRTSK
     PRLSLSSNGS LPIPIPMPIP IQGRWEAEAE SGEPGAHAGD AEESKLTEEE KALMREEFEG
     GLLEAGLQIE RDKERSNGMG FIRLHIPWSI LSREAELQKI KVAVKKVSSF TQSVTYLGIN
     SLLARGVYVA AFPLHDPGRC SFVHRKYFGE QIGLYFAWLG VYTQLLIPPS VLGIIVFLYG
     ILTVDTNVPS QETCNDSLNI TMCPLCDGVC DYWRLSSVCS LARASYLFDN GATVLFAIFM
     SLWAAWFLEH WKRRQMYLKH TWDLTSLEDE EVLKTKIICM FSWQQEPESL DIEDHLPGYL
     INISTLLLLI FITFSAVFGV AVYRICMLSV WSMNPDPEAK ASVRMTVTTT GIILNMLVVL
     VLEEVYGAIA VWLTELELPK TTEEFEERLI FKSFFLKSMN AFAPIFYVAF FKGRFAGRPG
     DYVYVFGDYR MEECAPPGCL IELCIQLSMI MLGKQLIQNN VFEILLKKMY RTIQEQKGKN
     RGAEDEDSET EEKRPKQQFD KDFTLEPFEG VSPEYMEMII QYGFVTLFVA SFPLAPAFAL
     LNNVIEIRLD AAKFVTEIRR PDAVRCKDIG IWYNILCGIS KFSVITNAFV ISFTSEFVPR
     MVYQYMYSVN GTMSGYTEHS LSYFDVSNFP SGTAPNTTLI TGVSMCRYKD YRDPPWATDA
     YTFSKQYWSV LAAKLAFVIF FQNLAMFLSM LVAWMIPDVP RSLREQLKKE NMLLMEFLPD
     APPCLLATEG LRLATACQGP ATPPASPGSS RSPHLFPWLP WTLHHQLHPA HYLPHTHRHP
     HHLHSLYLPN STKPQLNCLC
//