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Database: UniProt
Entry: I3KD18_ORENI
LinkDB: I3KD18_ORENI
Original site: I3KD18_ORENI 
ID   I3KD18_ORENI            Unreviewed;      3081 AA.
AC   I3KD18;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   08-MAY-2019, entry version 55.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000019013};
GN   Name=lama1 {ECO:0000313|Ensembl:ENSONIP00000019013};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000019013, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000019013}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C.P., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AERX01038603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01038604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01038605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01038606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01038607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01038608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000019013; -.
DR   Ensembl; ENSONIT00000019030; ENSONIP00000019013; ENSONIG00000015109.
DR   eggNOG; ENOG410IP6B; Eukaryota.
DR   eggNOG; ENOG410ZVV8; LUCA.
DR   GeneTree; ENSGT00940000157124; -.
DR   InParanoid; I3KD18; -.
DR   OMA; NPKERHP; -.
DR   TreeFam; TF335359; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
DR   GO; GO:0048854; P:brain morphogenesis; IEA:Ensembl.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0061303; P:cornea development in camera-type eye; IEA:Ensembl.
DR   GO; GO:0003412; P:establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis; IEA:Ensembl.
DR   GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
DR   GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
DR   GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR   GO; GO:0060035; P:notochord cell development; IEA:Ensembl.
DR   GO; GO:0007634; P:optokinetic behavior; IEA:Ensembl.
DR   GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR   GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR   GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR   GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:Ensembl.
DR   GO; GO:0061053; P:somite development; IEA:Ensembl.
DR   Gene3D; 2.60.120.1490; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR009254; Laminin_aI.
DR   InterPro; IPR010307; Laminin_dom_II.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR000034; Laminin_IV.
DR   InterPro; IPR008211; Laminin_N.
DR   InterPro; IPR038684; Laminin_N_sf.
DR   Pfam; PF00052; Laminin_B; 2.
DR   Pfam; PF00053; Laminin_EGF; 17.
DR   Pfam; PF00054; Laminin_G_1; 4.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   Pfam; PF06008; Laminin_I; 1.
DR   Pfam; PF06009; Laminin_II; 1.
DR   Pfam; PF00055; Laminin_N; 1.
DR   SMART; SM00181; EGF; 11.
DR   SMART; SM00180; EGF_Lam; 15.
DR   SMART; SM00281; LamB; 2.
DR   SMART; SM00282; LamG; 5.
DR   SMART; SM00136; LamNT; 1.
DR   SUPFAM; SSF49899; SSF49899; 5.
DR   PROSITE; PS01248; EGF_LAM_1; 5.
DR   PROSITE; PS50027; EGF_LAM_2; 15.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR   PROSITE; PS51115; LAMININ_IVA; 2.
DR   PROSITE; PS51117; LAMININ_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00122,
KW   ECO:0000256|SAAS:SAAS00814887};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00580772};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|SAAS:SAAS00814929};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   3081       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003674524.
FT   DOMAIN       18    269       Laminin N-terminal. {ECO:0000259|PROSITE:
FT                                PS51117}.
FT   DOMAIN      270    326       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      327    397       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      398    450       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      451    498       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      519    700       Laminin IV type A. {ECO:0000259|PROSITE:
FT                                PS51115}.
FT   DOMAIN      734    782       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      783    840       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      841    893       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      894    942       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      943    989       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      990   1035       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1036   1081       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1082   1140       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1170   1354       Laminin IV type A. {ECO:0000259|PROSITE:
FT                                PS51115}.
FT   DOMAIN     1397   1445       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1446   1502       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1503   1552       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     2117   2298       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2306   2482       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2489   2673       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2729   2896       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2901   3078       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   COILED     1616   1636       {ECO:0000256|SAM:Coils}.
FT   COILED     1658   1678       {ECO:0000256|SAM:Coils}.
FT   COILED     1816   1836       {ECO:0000256|SAM:Coils}.
FT   COILED     2008   2049       {ECO:0000256|SAM:Coils}.
FT   DISULFID    292    301       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    364    373       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    398    410       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    426    435       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    469    478       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    752    761       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    811    820       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    865    874       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    877    891       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    894    906       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    896    913       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    915    924       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    943    955       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    963    972       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1008   1017       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1036   1048       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1038   1055       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1057   1066       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1082   1094       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1111   1120       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1416   1425       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1473   1482       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1503   1515       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1505   1522       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1524   1533       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1536   1550       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   2646   2673       {ECO:0000256|PROSITE-ProRule:PRU00122}.
SQ   SEQUENCE   3081 AA;  336401 MW;  887B1112B9455E44 CRC64;
     ARMKVLLLLL LMGQAAAQHR GLFPAILNLA SNAVISSNAT CGEPEPEVYC KLVEHVPGRR
     IKNPHCLKCD ANSVLSRERH PITNAIDGTN RWWQSPSIKN GQQFHWITIT LDLKQVFQIA
     YIIIKAANSP RPGNWILERS LDGISFEPWQ FYAISDSECL YRYNITPRLG PPTYKSDTEV
     ICTSYYSRLN PLEHGEIHTS LINGRPGADD LTSDLLNFTS ARYIRLRLQR IRTLNADLMT
     LSARDPREID PIVTRRYYYS IKDISVGGMC ICYGHAQSCP LDPVSKKLHC VCEHNTCGES
     CNKCCPGYHQ QPWQPGTISD GNTCEKCNCH NKADNCYYNQ TISDLSLSLN THGVRRGGGV
     CFNCQQNTAG INCETCKDGY YRPAENVSLH ADFPCVECKC DLRGSKSSVC TRDNTQPGLL
     VGQCMCKEGF AGQQCDRCAF GYRDFPQCVR CECNLSGSIN TDPCSPCICK ENVMGAHCDL
     CKPGFFNLKE SNPLGCTSCF CFGVSDVCES SGLSIGQVVT AEALLFLSET ITTTPVFHSN
     EIPIHSNISS GATHQQMLWW EAPQSFLGNK LLSYGGFLKY FVVYDAPLDF ENPTLSAHCD
     IIIKGNGLAL RLSRPLPLSL STLAEHLVSV PMVWQQFVYD QTGSHVTRDD LLLVLADVTS
     LVVRVYLNTS ASGTIRLSSV SLDIGDPSLH SEVQALAVER CECPWGYSGT SCESCLPGFY
     RVGGILFGGN CMQCECNDHA TECDIHGVCV ACTHNTTGSH CDQCLQGFYG DATEGTTDDC
     QLCPCPLTEP SNRFSPTCVL DPSGQVLCDQ CKDGYTGTNC EKCASGFYGN PQVVGGTCIR
     CECNGNVDIS EVGHCDTVTG ECLRCLGNTA GRHCELCQPG YYGDAVHTKD CWECDCDVNG
     ALSSQCNVTT GQCFCRENVT GRTCDHCKSG FYGLQSGHGC IPCGCSKSGS LFESCDKEGQ
     CQCVEGVTGH KCDRCSRGYY GFHDKGCIAC SCDHTGGNCN PENGECICPA HTEGETCNKC
     VKNYWGHNPT TGCKPCSCSE AGSSSPLCDL TNGQCLCKEG FFGRSCDQCA PGYYGYPACS
     ACGCDMAGTE ETFCNATLGV CSCQNTGNCV CKPGVSGRRC EECVSGWFGL SAENLDGCLQ
     CFCSGLSRDC EEQGGLTRVP VYLAYSATLP FLSLVSQSNL QGTVSGVYRQ GSEMLLDTRQ
     LNTSGLTGPL YWRLPNQFEG NQLLSYGGLL SYTVTFYAED GAGLSNQEPQ VLMRGGTLRK
     LAIYTDIIAP GNGVTTQHDI RLTEHKWKYF NSVSQRVVSH ADFMSVLSNI EYIIIKASYG
     TRLQQSRISN ITMEMAVEVE ESEVRENVAR LIESCICPPG YTGLSCQDCD VGHFHQPQSE
     LSPQSKKSMF VRPCVPCRCN NHSQSCYTET GECQDCKHHT SGQSCEKCAS GYYGSVKGFI
     DDCSPCACPL LNNSFSPTCI LEGAAGDFRC TACQPGYEGR YCERCSVGYY GNPSVPGGVC
     SQCSCTAWGS LHLLCDVLTG ECECKDGVKG QSCNECEERN IFQEGECPAC DDKCTGILLD
     ELDELHNHFL FFNLSTIAMS SYRQLWLLEN QTREMQVVSS QNNSVMVSLS RVEEGLNYLT
     SELDSLLQQV NSLSNDVQIV DVSTNNSFSR GALLLEGISR LQNNIQLLQR EAAHLNQTAE
     EELGSANQTH LLEDVESILN SIKDVNLTAA EVVANQELSR SESLFQSVQI NFLSSRVATG
     DKLGPLSTSL TADIKTLQHA NTTLSDTVQQ TIETNFLLDT AHTLLQRYQS GHQNLSVVCL
     SLDSQMEDSQ LLLEDAVSLT EELTNHTRQV EVLAAELDQW RPLLRKQVNG LVMGLKKNDA
     LENVYRAEKH AHLLQSYAHS LHSPLSSVCN MSQNGSQLAQ FDSDITERVD SAHQMASVAL
     VSASLALNMS VQSEQPLSEE GRAKLEVSSA ILEESRRIGS AAEDLQLNVS MVTIRLRLVR
     DSVHNSSFLL RKPVKVLQSL SNGSSEALQQ TQIQAAAAHS KLQEAMQRLQ RLRAQLKDSS
     SLVENANNTL RETSQLVTLT HIAANEMQHK MEEAEYRTQH LMDRIKPMRM LGETLSRNLS
     DIRELIYQAR RQAASIKVAL QADRGCVRSY RPSVQSSNFN TLNLIVKTTT PDNLLFYLGS
     NTTMDFLAAE MHNGQVSLLW DVGSGSTRLE FPGLDITNNR WTKINATRFG PHVALSVHQL
     DSKSALLPAV TATSPGTFQV LDIDENSFVH IGGLGAHTQR PAALRSTTFQ GCLGEASLNE
     QNIGLWNYDH REGECGGCFS SPQAEETSFH FDGSGYSVVQ KSLRSTSTLI VLQFKTLSPV
     GLLLYLASNN TRDFLSMELV EGRVRLTFDL GSGALMLTSN RKYNTGVWYK ITLQRNKRKG
     YLSIMAADQS SEKEVLEADS PGKASDLNRS DLDPIFIGGF PASRPIRRQV ASRSYVGCIK
     NVEIARSNFD LLRDAHGVRK GCILKAVRSV SLLAGGYVQI TPPSFGQEAE LLFSFSSNNQ
     SGVLLAAFSS DRSHKQYVQH FLSVHLVSGA LEVELGEVGG ATRKVTVIKP DGRSFSDRMK
     HSAIITINKK SLSIQIDEEH KKLVSLLPGV FSQLSPASLF IGGLPSGNEA RLPIRLQKLS
     RLFKGCIQHL AVGRVLVDLS GALRYEGVKF DKCVLEEKAG DVLLPDDQDV NVTPDPTHLP
     LPQPTQLGAL SPEGLMCASD GELTFVPSAV QFGLSRHSHM TFIINPSTVR KSVSVRLLFR
     SWALDGLILL LSDSKQMDFV VLSLKGGRLM MSADLGKGLA SITSSVAVNN GEWHTVVAEV
     GRRLMSVSVN SLKTDSISVK GNQLDVDNKV FLGGTPHTMT SRRIRDSSSF SGCVGSISLN
     GVMLDKPASQ HGVTSCFTRD QIGSYFNGSG YAEMMHDGYK VGSDMTVSLE FQTSQSEGVL
     LGISSAKVDA VGLEIINGQV VFNVNNGAGR VSVRSVGQML CDGQWHRLVA QKTKHAFSLT
     VDERTYTTAN PYPQSTSAET NNPVFLGGYP AGVKQNCLSI SSSFRGCLRN LQLLKSHLTK
     SLDLSSAHFL LGITPNSCPA S
//
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