ID I3KD37_ORENI Unreviewed; 1024 AA.
AC I3KD37;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Synemin {ECO:0000313|Ensembl:ENSONIP00000019032.1};
GN Name=LOC100712528 {ECO:0000313|Ensembl:ENSONIP00000019032.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000019032.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000019032.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003440648.1; XM_003440600.4.
DR AlphaFoldDB; I3KD37; -.
DR STRING; 8128.ENSONIP00000019032; -.
DR Ensembl; ENSONIT00000019049.2; ENSONIP00000019032.1; ENSONIG00000015124.2.
DR GeneID; 100712528; -.
DR KEGG; onl:100712528; -.
DR CTD; 23336; -.
DR eggNOG; ENOG502QTUH; Eukaryota.
DR GeneTree; ENSGT00940000159268; -.
DR HOGENOM; CLU_002793_0_0_1; -.
DR InParanoid; I3KD37; -.
DR OMA; KMLYASE; -.
DR OrthoDB; 5353519at2759; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0008307; F:structural constituent of muscle; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR030634; SYNM.
DR PANTHER; PTHR47136; SYNEMIN; 1.
DR PANTHER; PTHR47136:SF1; SYNEMIN; 1.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 11..318
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 361..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 8..49
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 111..152
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 202..236
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 361..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..698
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 115833 MW; 21209F5043B72741 CRC64;
MLPFKRTFES EKHQLQELNS RLAQYLSRTK QLEQENAHLI AEINKLRQVR TTGWETKYRA
EMQDLRRMVG QLSFEKSQAE MEREKLWREL QMIQSLCSEQ TDVCRDVSGE LKNCEKELHH
AHKTNSELQQ RLLQLENEYK RLEDAHREEV SRVCRQVESR VAPIIRQTYR GPPVVSVEEV
QEYAHGMSEG WIQTFEMYQK TVEDMEQSIK ADQAMLNDLQ REKMRYASEL DKLRTEAEKQ
GQIQIRLEEQ LMHMQEKFRV DFSQYQMTIE QLEHERNVMA DVIAQKMREH QQLLQVKMDL
GMEVAAYRAL LEGERIGLQD AHKRVNQHQR ERIIDIKMPA QRYTPRASTL TTKQHMDIRY
TPSTSSLRRS PMPSSGSISP SRVIPISVTG RARHQSPASR RDMISFNKAR AAASASATTI
TTTSTTTKDK QAGHSENQVS RSAPKRTAEE QTVKLIWLPH TEGQMSPDKS STPDTKSVRV
VSSSMKSLVT ETETESKKYV SDEKEKGPVV DGEVKDKGRT ESTIGPAEKK ILDSVSVEEI
IEKVIKPAGL EAKVCSSGDS KVRYHVEKTE QEDGTTKTQI VLESKVEEEL DVSQDYALEE
LLKQGVKKVS LEDIKDTATG SMVKNLLSGL QGGEDLQNKS VNVEIIEEPV ESYSDEEFEA
EQKSGLTFHE PSAYFQVEEP ENIPHGIQDS RGDDNVVKSN TDEPQFGSVQ VQEVSRESES
PHFSHDQESH EYFVSTPDEN LSESEEGGGI TSYGHYGIVD DLSDERYYQD DGLPQKKVTV
EESDEYEFMS GDRSFAKESF PECIIEEEVR VSPIVQESVL EYLREDSLEP KEQLKGALEK
LQSSVSGPLK EELAFLTKVS SESPENVAVD VKKVEQSTDN GTMTIVAELN VSQTLEESGL
LEGDDLSEDQ IMAALKSSNI GIEKAFQSGA GGGYSIRVSR EDNVAHSVEY GDFSDKGESA
SEISEKHFKL GPSDKSFAFQ MDVHGGHDEA ASEQELQPPV LEMPVKISQE KRIATVYLES
PSND
//
