ID   I3KFM5_ORENI            Unreviewed;       403 AA.
AC   I3KFM5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Cytohesin 1b {ECO:0000313|Ensembl:ENSONIP00000019920.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000019920.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000019920.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3KFM5; -.
DR   STRING; 8128.ENSONIP00000072459; -.
DR   Ensembl; ENSONIT00000019937.2; ENSONIP00000019920.2; ENSONIG00000015825.2.
DR   eggNOG; KOG0930; Eukaryota.
DR   GeneTree; ENSGT00940000157519; -.
DR   HOGENOM; CLU_032820_3_0_1; -.
DR   TreeFam; TF352091; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd01252; PH_GRP1-like; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663:SF340; CYTOHESIN-1; 1.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          61..248
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   DOMAIN          266..382
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   COILED          26..60
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   403 AA;  46862 MW;  D29FC8CDF7A8E9A8 CRC64;
     MDQRLLLHIL LSSVPDDLSP EERQELDSIR RRKQELLQDI QRLKDEIAEV TSEIENLGLT
     EERKNMQRNR QMAMGRKKFN MDPAKGIRFL IDCSLLKNTS EDIAQFLYKG EGLNKTAIGD
     YLGERDEFNI KVLHAFLELH EFTDLNLVQA LRQFLWSFRL PGEAQKIDRM MEAFARRYCH
     CNPGVFQSID TCYVLSFAVI MLNTSLHNPN VKDKPSVQKF TAMNRGINDG GDLPEDLLRN
     LYDSIKNEPF KIPEDDGNDL THTFFNPDRE GWLLKLGGRV KTWKRRWFIL TDNCLYYFEY
     TTDKEPRGII PLENLSIREV EDSKKPNCFE LFIPNHKDQV IKACKTEADG RVVEGNHTFY
     RISAPTAEEK DEWIKSIKAA ISKDPFYEML AARKKKVSSL KGL
//