ID   I3KFX2_ORENI            Unreviewed;       524 AA.
AC   I3KFX2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=Metastasis-associated protein MTA3 {ECO:0000313|Ensembl:ENSONIP00000020017.2};
GN   Name=LOC100696254 {ECO:0000313|Ensembl:ENSONIP00000020017.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000020017.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000020017.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3KFX2; -.
DR   STRING; 8128.ENSONIP00000045614; -.
DR   Ensembl; ENSONIT00000020034.2; ENSONIP00000020017.2; ENSONIG00000015893.2.
DR   eggNOG; KOG3554; Eukaryota.
DR   GeneTree; ENSGT01030000234573; -.
DR   HOGENOM; CLU_006585_2_0_1; -.
DR   TreeFam; TF106444; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd04709; BAH_MTA; 1.
DR   CDD; cd11661; SANT_MTA3_like; 1.
DR   CDD; cd00202; ZnF_GATA; 1.
DR   Gene3D; 2.30.30.490; -; 1.
DR   Gene3D; 4.10.1240.50; -; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR043151; BAH_sf.
DR   InterPro; IPR000949; ELM2_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR040138; MIER/MTA.
DR   InterPro; IPR035170; MTA1_R1.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   InterPro; IPR000679; Znf_GATA.
DR   PANTHER; PTHR10865; METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN; 1.
DR   PANTHER; PTHR10865:SF6; METASTASIS-ASSOCIATED PROTEIN MTA3; 1.
DR   Pfam; PF01426; BAH; 1.
DR   Pfam; PF01448; ELM2; 1.
DR   Pfam; PF00320; GATA; 1.
DR   Pfam; PF17226; MTA_R1; 1.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   SMART; SM00439; BAH; 1.
DR   SMART; SM01189; ELM2; 1.
DR   SMART; SM00717; SANT; 1.
DR   SMART; SM00401; ZnF_GATA; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS51038; BAH; 1.
DR   PROSITE; PS51156; ELM2; 1.
DR   PROSITE; PS51293; SANT; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          2..149
FT                   /note="BAH"
FT                   /evidence="ECO:0000259|PROSITE:PS51038"
FT   DOMAIN          150..261
FT                   /note="ELM2"
FT                   /evidence="ECO:0000259|PROSITE:PS51156"
FT   DOMAIN          268..320
FT                   /note="SANT"
FT                   /evidence="ECO:0000259|PROSITE:PS51293"
FT   REGION          419..449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        427..449
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   524 AA;  59930 MW;  6DABD8787D55D925 CRC64;
     MCVFPVADYV FFENSSSNPY LIRRIEELNK TASGNVEAKV VCFYRRRDIS HSLIQLADKH
     ASEKKAILEE EKENPTDTEL TEKQKHQLRH RELFLSRQYE SLPATHIRGK CSVALLNETE
     AVLSYLDKED TFFYSLVYDP TQKTLLADKG EIRVGPRFQA DVPEMLQEGE ADERDQAKLE
     EKLWDPECPL TNKQIDQFLV VARAVGTFAR ALDCSSSVRQ PSLHMSAAAA SRDITLFHAM
     DTLHRHNYDL SSALSVLVPA GGPVLCRDEM EEWSASEAAM FEEALEKYGK DFNDIRQDFL
     PWKSLTSIIE YYYMWKTTDR YVQQKRLKAA EAESKLKQVY IPTYNKPNPN QISMTNGKMA
     TVNGAGPGAY HAAGGGRACE SCYTMQSAQW YSWGPPNMQC RLCVSCWMYW KKYGGLKMPS
     RAEGPEERTS PTPSNHMVPM RNSNSPKSSM KTKQAFLLQA TRLTKLARHM CRDIIRLRRA
     ARRPFVPINC GAIKADELSQ PHMFIVNTEP QLHCLCHHHF QRIF
//