ID I3KGL2_ORENI Unreviewed; 869 AA.
AC I3KGL2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Serrate RNA effector molecule homolog {ECO:0000313|Ensembl:ENSONIP00000020257.2};
GN Name=LOC100710359 {ECO:0000313|Ensembl:ENSONIP00000020257.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000020257.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000020257.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ARS2 family.
CC {ECO:0000256|ARBA:ARBA00005407}.
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DR RefSeq; XP_005462882.1; XM_005462825.3.
DR AlphaFoldDB; I3KGL2; -.
DR STRING; 8128.ENSONIP00000020257; -.
DR Ensembl; ENSONIT00000020274.2; ENSONIP00000020257.2; ENSONIG00000016080.2.
DR GeneID; 100710359; -.
DR KEGG; onl:100710359; -.
DR eggNOG; KOG2295; Eukaryota.
DR GeneTree; ENSGT00390000005492; -.
DR HOGENOM; CLU_008560_0_0_1; -.
DR InParanoid; I3KGL2; -.
DR OMA; HLRMCEE; -.
DR OrthoDB; 4174205at2759; -.
DR TreeFam; TF317609; -.
DR Proteomes; UP000005207; Linkage group LG3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR039727; SE/Ars2.
DR InterPro; IPR007042; SERRATE/Ars2_C.
DR InterPro; IPR021933; SERRATE/Ars2_N.
DR PANTHER; PTHR13165; ARSENITE-RESISTANCE PROTEIN 2; 1.
DR PANTHER; PTHR13165:SF0; SERRATE RNA EFFECTOR MOLECULE HOMOLOG; 1.
DR Pfam; PF04959; ARS2; 1.
DR Pfam; PF12066; SERRATE_Ars2_N; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 145..254
FT /note="SERRATE/Ars2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12066"
FT DOMAIN 645..843
FT /note="SERRATE/Ars2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04959"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..351
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..782
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 869 AA; 98849 MW; BB798044B09F7426 CRC64;
MGDSDDDLDR RRRDKFRRER SDMERSRERE ERRRDDWPDR DWDRGRERRR DYDRGRRERF
SPPRHISPQH KRMRREWDDH RGEPYRYDLP YGGGGAPFPG AGPQGWHPDF PHLHPHHGGH
PLQGRLGMVD PDLPPPGPPT MRSFKEFLLN MEDSVDETEA VKRYNQYKLD FRRQQLQDFF
LQHKEQEWFR SKYHPDDITT RKAESLAALK TRLGVFLFLM DNNWLDNVSL DMDHAPAIIK
LLDAAVIKME GGTDFDLQVL EVQANAAGAG GDTSGGGGVG ENSQADASGG SVGGQTSSEA
TVTQMKETAS GDAGDNKETE KESADAKRNG KKEKDDDEEE EEEEKKEEEE DEEEEKKTKK
GRKRKRSLSA DSGEGSASDS DSSHSDGEKD EDEEKEEEED DGEDERRKER GKEREKEAPP
KPRPLHLTTS LFIRSIPPEV SKDEITALCR RYPGFLRVAL SDPQPERRFF RRCWVTFDRS
VNIKETCWNL QNIRLRDCEL APVVNRDLCR RVRSVNGLTH HKPVVRNDIR LSARLVHSLD
QRGELWTEQM ETNPILKNIT DYLIEEVSAE EEELIGASGG NTDDAGDAKD PASSDVTLET
DDKLLKVLDR LLLYLRLVHS VDYYNFCEYP AEDEMPHRCG LIHVRGPLPV GKITATEVSE
HQRMCEERLA PLLSPSETLS EEEATRLGKK DPEQEVEKFL SANTQELSKD KWLCPLSGKK
FKAPEFVRKH ILNKHGEKVS GVRQEVEFFN NFLLDAKRPA LPENKPLPPP SQAAPPGLPG
FPGQSPQQQS LLGYPPGVRP PMPGFPGGAL HHPPNQFGAG RGNYDNFRGH LGGGGGFSGK
QRNSRGMRGD PRSIIEYRDL DAPEDLDFF
//
