ID I3KGQ2_ORENI Unreviewed; 1625 AA.
AC I3KGQ2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=IQ motif containing GTPase activating protein 2 {ECO:0000313|Ensembl:ENSONIP00000020297.2};
GN Name=iqgap2 {ECO:0000313|Ensembl:ENSONIP00000020297.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000020297.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000020297.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSONIT00000020314.2; ENSONIP00000020297.2; ENSONIG00000016113.2.
DR GeneTree; ENSGT00950000183076; -.
DR Proteomes; UP000005207; Linkage group LG12.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF12; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 44..160
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 647..674
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 965..1198
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 897..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 169..196
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1625 AA; 185674 MW; DDAC40F77DDDEEDB CRC64;
APELEIFPFT QPEINRFDRI RDDERLSAEE MDERRRQNIA YEYLCHLEEA KRWMEACLEE
DLPPTTELEE GLRNGVYLGK LAMFFAPKMV SEKRIYDRDQ SRYKVSKGLH FRHTDNTVQW
LRAMESVGLP KIFYPETTDV YDRKNMPKVV YCIHALSLYL YKLGIAPQIQ DLLGKVDFTE
EEISNMRSEL EKYGIQMPAF SKIGGILANE LSVDEAALHA AVIAINEAVD RGQASVTMEA
LNNPNAMLRN THEPLAQEYQ DTLSQTKSRK RDQSSGRVRR LTNTSVISWT QEAIRQVNHA
VSNQDKAALL AALRLNALAL LGVQESNSRW YLEHFTNYCQ HKSKVYRVRV CLLKLEAVTR
INTAIRLGNA LETVEELMNP EAQLPIVYQT AANLYQAELF SLQLQGGRSG LGHEELSVAV
EMLSAVAVLN EVLDTKDPQA VIEQLTDSPL GFTNIDQDNL NRYADMLVKE RAEALSKGQE
FLTWNDVQKC IDTVNVQVQE EHERIIAIAE INEALNSGDH EQTLAALLLP TAKLSGVNPA
TAKHYHDVLQ NTKQLLCKSS GDESAVLWLD QIQEAILTAN QDEKEALALS GAVAHINRTV
NEGDSQNTLE ALQAPSVGLR AVLPECADTY QDDLSQKQRD GSTDGVWVKH CIKDKYDYFY
NLETEEGTWE EPEGFEQKSG HLSKEEIQNV VTCVTAEYNR EQLWLANESF VTKLQARVRG
YLVRKKHAQR MEYLHQQEPH VIKLQACWKG YKQRKVYKER MNLLQKNVAS IVKIQSFVKM
WKAKREYNQR QQFFKDHEKE IVKIQAFLKA NKAREDYRTL TGAKDPPLSV VRKFVHLLEQ
SPLDLQEEQE VTRLREEVVT KIRSNQQMEK DLNLMDIKIG LLVKNRITLQ DVVSHNKKMK
SKKSKASKDD PMAGDRLGIK GLSKGKRRKL EAYQHLFYLL QTNPSYLAKL IFQMPQNKST
KFMDTVIFTL YNYASNQREE YLLLKLFKTA LEEEINSKVD QIQDIVTGNP TVIKMVVSFN
RGARGHNTLR QLLAPVIKDI IEDKSLGLNT NPVEVYKAWV NQLESATGEA SKLPYEVTPE
QAMSHEEVRN RLQASSQALR SATDKVLNSI VSSLDNLPYG MRYIAKVLKN SLHEKFPDAS
EDELLKIVGN LLYYRYMNPA IVAPDGFDII DLSAGGQLHQ DQRRNLGSVA KMLQHAAAKN
VFEGENAHMT PMNSYISQTY EKFRLFFQSA CDVPEPEEKF NIDEYSDMVN LSKPIIYISI
EEIINTHSLL LEHLDAISPE RNDLLHELLQ DLGDVPDVEA LLGEGAVDPN DPNRESALSQ
LAKTEISLTL TSKFELLEGD DRDLKTLSTK TKKLIVDVIR IQPGETLPEI LETPATAAQE
SEHTRIVERR AVQDAQTPEG LKSSPAFLED IQLPLEQKKR KIIRNLRNLE QAGLATASNK
YQDLINEISK DIRYQRRYRQ RRKAELVKLQ QTLTALNSKT AFYQDQMNYY DAYIKTCLDN
LNRKNSRRSI KLDGKGDDKG SKKWKPQSLK YTAAKLHEKG VILEIEGLQT NQFKNVMFDI
SPTEEVGDFE VKAKFMGVEM EKVQLHFQDL LQLQYEGVAV MKMFDKAKVN VNLLIFLLNK
KFYGK
//
