ID I3KGR6_ORENI Unreviewed; 587 AA.
AC I3KGR6; A0A516UWW4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
DE EC=2.3.2.27 {ECO:0000256|PIRNR:PIRNR015614};
GN Name=LOC100697176 {ECO:0000313|Ensembl:ENSONIP00000020311.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000020311.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QDQ70121.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31326588;
RA Xia H., Li Y., Wang Z., Chen W., Cheng J., Yu D., Lu Y.;
RT "Expression and functional analysis of tumor necrosis factor receptor
RT (TNFR)-associated factor 5 from Nile tilapia, Oreochromis niloticus.";
RL Fish Shellfish Immunol. 0:0-0(2019).
RN [3] {ECO:0000313|Ensembl:ENSONIP00000020311.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|PIRNR:PIRNR015614};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR015614}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000256|PIRNR:PIRNR015614}.
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DR EMBL; MN149369; QDQ70121.1; -; mRNA.
DR RefSeq; XP_003452807.3; XM_003452759.4.
DR STRING; 8128.ENSONIP00000020311; -.
DR Ensembl; ENSONIT00000020328.2; ENSONIP00000020311.2; ENSONIG00000016125.2.
DR GeneID; 100697176; -.
DR KEGG; onl:100697176; -.
DR CTD; 7188; -.
DR eggNOG; KOG0297; Eukaryota.
DR GeneTree; ENSGT00940000163836; -.
DR HOGENOM; CLU_021061_4_1_1; -.
DR OMA; HVQSLCP; -.
DR OrthoDB; 2913784at2759; -.
DR TreeFam; TF321154; -.
DR Proteomes; UP000005207; Linkage group LG6.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF83; TNF RECEPTOR-ASSOCIATED FACTOR 5; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF02176; zf-TRAF; 1.
DR PIRSF; PIRSF015614; TRAF; 1.
DR SMART; SM00061; MATH; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 3.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR015614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR015614}; Receptor {ECO:0000313|EMBL:QDQ70121.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015614};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 70..112
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 155..208
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 209..259
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 429..579
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT ZN_FING 155..208
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 209..259
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 66254 MW; 3B280D74F6CBCB46 CRC64;
MATANTNQGG SPEESSVPSE NYSLRSEESR LGSEESRRRL SSPTVSWDSE LASIRHRLKF
VLKLKEEFVC PICRGVVLNP QQNSCGHIYC FHCLQGLLES SSPSNPVCPV DRAVITPTEV
FQDNCCKREI SSLEVYCTNA PTCTAIFTLN DLQEHLKSCQ YEQVQCTNTS CIAVLQRRHL
QEHLTNICPY RREPCPHCRQ LFQLSLIQAH VQSLCPDVKV DCPEGCSQKV PRHKLTSHRQ
LCPEVNSDCC FKKFGCSVQG KRRNAKLHED KAINHHMLLV LRSNTHLEQQ IDVFQEDSLL
MQQEVQTDTL LLTGLQKQIR PLLQLSSNHE HAVSMAQRTL RRQEDTLSSV QLDLQQVSRA
LHPHLEELSQ LRKSLDVAMQ EVSEVEALRE HLGTLEEKLK RHSGLLHLHA AQLNLNKKHL
QELEATSYDG KLIWKIEDFG KRSGAEAKGQ LSCLTSVPFY TGRCGYKMAI KAYLNGDGEG
RGTHLSLYVV LMPGDFDTLL PWPFKQTVSL SVLDQSGASN HRSLSFRPDP TTKCFQQPTP
ESQSNVAVGF PCFISHNMLE TPQNAVYVKD NTLFVKAKVD MTGFEQL
//
