ID I3KHM4_ORENI Unreviewed; 249 AA.
AC I3KHM4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Tumor necrosis factor ligand superfamily member 14 {ECO:0000313|Ensembl:ENSONIP00000020619.1};
GN Name=LOC102082760 {ECO:0000313|Ensembl:ENSONIP00000020619.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000020619.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000020619.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR RefSeq; XP_005454873.1; XM_005454816.3.
DR RefSeq; XP_013129726.1; XM_013274272.2.
DR AlphaFoldDB; I3KHM4; -.
DR STRING; 8128.ENSONIP00000020619; -.
DR Ensembl; ENSONIT00000020637.2; ENSONIP00000020619.1; ENSONIG00000016374.2.
DR GeneID; 102082760; -.
DR KEGG; onl:102082760; -.
DR eggNOG; ENOG502RZ4W; Eukaryota.
DR GeneTree; ENSGT01060000248544; -.
DR HOGENOM; CLU_070352_5_0_1; -.
DR InParanoid; I3KHM4; -.
DR OMA; HYYLYSK; -.
DR OrthoDB; 3851574at2759; -.
DR TreeFam; TF332169; -.
DR Proteomes; UP000005207; Linkage group LG6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF34; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..247
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 249 AA; 28039 MW; 7C06C71F014EC0A8 CRC64;
MSEGGVGACP QVFVVDSQAS YLKMPPERKP RGSQLQKLLL LLVGLAMLGI IVEGFLIYRL
FQKTEEFSLF NHEHDLKNRS NPKPEGLMGQ MRDGKMSGDE RRPFAHLLGS NSPTGENDVV
QWAKEGEAVT QDMKYKEGRL IVEKEGYYYI YSKVIINAVE ECSLSQHKVM KKTKAYDKPI
ELMQSKSIHC STSKPHSKPP ETSEDLWNSY LAGIFQLQVG DEIYVTLKNI TKIRPGSSLN
FMGAFMVSP
//
