ID I3KHQ7_ORENI Unreviewed; 1405 AA.
AC I3KHQ7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Ankyrin 2 {ECO:0000313|Ensembl:ENSONIP00000020652.2};
GN Name=ANK2 {ECO:0000313|Ensembl:ENSONIP00000020652.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000020652.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000020652.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 8128.ENSONIP00000075192; -.
DR Ensembl; ENSONIT00000020670.2; ENSONIP00000020652.2; ENSONIG00000016398.2.
DR GeneTree; ENSGT00940000155279; -.
DR HOGENOM; CLU_000134_7_1_1; -.
DR Proteomes; UP000005207; Linkage group LG3.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 20.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 18.
DR PROSITE; PS50088; ANK_REPEAT; 19.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 1..26
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 27..50
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 89..121
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 122..154
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 155..187
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 188..220
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 221..253
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 254..286
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 287..319
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 320..352
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 353..385
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 386..418
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 419..451
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 452..484
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 485..517
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 518..550
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 551..583
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 584..616
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 617..649
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 658..724
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 799..954
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 956..1103
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1282..1365
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 1405 AA; 154936 MW; 9995FAF52AD998DD CRC64;
MAAQENHLDV VRYLLENGGN QSIATEDGFT PLAIALQQGH NQVVSVLLEN DTKGKVRLPA
LHIAARKDDT KSAALLLQND HNADVQSKSG FTPLHIAAHY GNVNVATLLL NRGAAVDFTA
RNGITPLHVA SKRGNTNMVR LLLDRGSQID AKTRDGLTPL HCAARSGHDT AVELLLERGA
PLLARTKNGL SPLHMAAQGD HIECVKHLLQ HKAPVDDVTL DYLTALHVAA HCGHYRVTKL
LLDKRANPNA RALNGFTPLH IACKKNRVKV MELLVKYGAS IQAITESGLT PIHVAAFMGH
LNIVLLLLQN GASADVSNIR GETALHMAAR AGQVEVVRCL LRNGAMVDAR AREEQTPLHI
ASRLGKTEIV QLLLQHMAHP DAATTNGYTP LHISAREGQV ETASVLLEAG ASHSLATKKG
FTPLHVAAKY GSLDVAKLLL QRRAPPDSAG KNGLTPLHVA AHYDNQNVAL LLLDKGASPH
TMAKNGYTPL HIAAKKNQME IATVLLRYGA ETNILTKQGV TPLHLASQEG HADMAALLIT
KGAQINVPTK SGLTALHLAA QEDKVAVAEI LSRNAANLDQ QTKLGYTPLI VACHYGNAKM
VNFLLQNGAS VNAKTKNGYT PLHQAAQQGN THIINVLLQY GAKPNATTVN GNTALGIARR
LGYISVVDTL RVVTEEIITT TTTVTEKHKL NVPETMTEVL DVSDEEVVGF FIDNFISLLA
QGDDTMTGDG GEYLRAEDLR ELGDDSLPGQ YLDGMNYLRF SLEGGRTDRE AERDSYRLSW
GTENLDNVAL SSSPVHSGFL VSFMVDARGG AMRGCRHNGL RIIIPPRKCS APTRVTCRLV
KRHRLATMPP MVEGEGLASR LIEVGPSGAQ FLGPVIVEIP HFAALRGKER ELVILRSETG
ESWKEHHCEH TQEELNQILN GMDEELETPE ELERKRICRI ITRDFPQYFA VVSRIKQDSN
LIGPEGGILS STVVPQVQAV FPEGALTKRI RVGLQAQPVS IDVVRKILGN KASFSPIVTL
EPRRRKFHKP ITMTIPVPKS NSDPVLNGFG GDTPTLRLLC SITGGTTPAQ WEDITGTTPL
TFINDCVSFT TNVSARFWLI DCRQVQESVN FSTQVYREII CVPYMAKFVI FAKTHDPIEA
RLRCFCMTDD KIDKTLEQQE NFTEVARSRD VEVLEGKPIY ADCFGNLVPL TKSGQHHLFS
FYAFKENRLA LFIKIRDNTQ EPCGRLSFMK EPRNYRSLAQ NAICNLNITL PSYCKVRTLY
RCCWRSRVFM SKSYPQDEAE RKEQRLAIIA DHLGFSWTEL AQELDFSEER INEIRTGNPN
SLQDQSHALL KIWTEREGNL ATATLIKRLT KINRMDIVHL IESRTSDEET SHTYAEIEWT
IAQDHSEGTQ ASLNLRLRFT SNQIL
//
