ID I3KHS1_ORENI Unreviewed; 232 AA.
AC I3KHS1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Transmembrane BAX inhibitor motif-containing protein 6 {ECO:0000256|ARBA:ARBA00033086};
GN Name=TMBIM6 {ECO:0000313|Ensembl:ENSONIP00000020666.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000020666.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Ensembl:ENSONIP00000020666.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000256|ARBA:ARBA00010350,
CC ECO:0000256|RuleBase:RU004379}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU004379}.
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DR AlphaFoldDB; I3KHS1; -.
DR STRING; 8128.ENSONIP00000038215; -.
DR Ensembl; ENSONIT00000020684.2; ENSONIP00000020666.2; ENSONIG00000016410.2.
DR eggNOG; KOG1629; Eukaryota.
DR GeneTree; ENSGT01050000244940; -.
DR HOGENOM; CLU_061277_0_0_1; -.
DR InParanoid; I3KHS1; -.
DR OMA; AQKISNC; -.
DR TreeFam; TF323395; -.
DR Proteomes; UP000005207; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR CDD; cd10430; BI-1; 1.
DR InterPro; IPR006213; Bax_inhbtr1_CS.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR PANTHER; PTHR23291:SF122; BAX INHIBITOR 1; 1.
DR PANTHER; PTHR23291; BAX INHIBITOR-RELATED; 1.
DR Pfam; PF01027; Bax1-I; 1.
DR PROSITE; PS01243; BI1; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004379};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004379};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU004379};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT TRANSMEM 29..50
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 97..118
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 130..153
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 159..177
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
SQ SEQUENCE 232 AA; 26006 MW; 4FEB2046064798E8 CRC64;
MNAFDRSKTD ALFQFSHISH STQEHLKKVY SSLAICMCLA AVGSYVYIYL VARLVTVSAV
SPLTERKRLA VLEGFALLTG FDLGPILDSV IAVDPNIIAT AFVGTSVIFI CFTLSCLYDT
HRGHLFLRGT LVSSCSILLL AYLTSVFFGS TLLFEANTYL GLLVTCGFVL FDTQLIIEKA
ENGDKDYIWH CVTLFYDFIS IFRRLMIILY TKEKDKKTVS QRILCKMIPT DV
//
