ID I3KHZ8_ORENI Unreviewed; 597 AA.
AC I3KHZ8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Epsin-3 {ECO:0000313|Ensembl:ENSONIP00000020743.1};
GN Name=EPN3 {ECO:0000313|Ensembl:ENSONIP00000020743.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000020743.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000020743.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the epsin family.
CC {ECO:0000256|ARBA:ARBA00010130}.
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DR RefSeq; XP_003450077.1; XM_003450029.3.
DR AlphaFoldDB; I3KHZ8; -.
DR STRING; 8128.ENSONIP00000020743; -.
DR Ensembl; ENSONIT00000020761.2; ENSONIP00000020743.1; ENSONIG00000016470.2.
DR GeneID; 100695148; -.
DR KEGG; onl:100695148; -.
DR CTD; 571453; -.
DR eggNOG; KOG2056; Eukaryota.
DR GeneTree; ENSGT00940000158217; -.
DR InParanoid; I3KHZ8; -.
DR OMA; SGTHESA; -.
DR OrthoDB; 1532at2759; -.
DR TreeFam; TF313361; -.
DR Proteomes; UP000005207; Linkage group LG6.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR CDD; cd16990; ENTH_Epsin; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR003903; UIM_dom.
DR PANTHER; PTHR12276:SF16; EPSIN-3; 1.
DR PANTHER; PTHR12276; EPSIN/ENT-RELATED; 1.
DR Pfam; PF01417; ENTH; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00726; UIM; 2.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50330; UIM; 1.
PE 3: Inferred from homology;
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 12..144
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT REGION 146..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 64881 MW; 937D84AE8A0A4ABC CRC64;
MTTSALRRQV KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTFNV VAFAEVMGMV
WKRLNDSGKN WRHVYKALTL LDYLLKTGSE RVAQQCRENA FTIQTLRDFQ YVDRDGRDQG
ANVREKARQL VCLLRDEERL RQERSQALKT KERMAGGGSG GGGGVYGGIP PAYHPGRRTS
QPSMAVLYGE EFSRSRGSPS SFNSSSSSPR AASDLEQARP QTSGEEELQL QLALAMSREE
SQKEQRCRQG DESLLQKALD ESRRESQSGT HESAMLDLVD IFGSSSEPPL PPSDPWNSAQ
PTSNVSSDPW DSVAVHSSTP VIGSPWTAPP SSNNTSNPWA PCTNSRKDPW EAAPGSCSPV
NHAWDSPTDG DADGTDPFAA HEEEKPKQEI PAVSSPQPAS PTDAELFGTK PESDPFSGLD
SKQDPFGTEP PVKPQVNGRD SASPEMFDLS RLAPPLSAPA TRVCRTPEAF LGPTGASLVN
LDTLIPPNPP TKTHNNPFLS GLSAPSPTNP FHCDQPRLTL NQMRPSSTSP LPPHMLSYSP
SLPLPLLHQP PILPSSFTQP PAGLLDLPSN LPQPLLPLSP RPAPRTQSQT HSHNPFL
//
