ID I3KI77_ORENI Unreviewed; 872 AA.
AC I3KI77;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Inter-alpha-trypsin inhibitor heavy chain family member 6 {ECO:0000313|Ensembl:ENSONIP00000020822.2};
GN Name=ITIH6 {ECO:0000313|Ensembl:ENSONIP00000020822.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000020822.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000020822.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
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DR AlphaFoldDB; I3KI77; -.
DR Ensembl; ENSONIT00000020841.2; ENSONIP00000020822.2; ENSONIG00000016533.2.
DR GeneTree; ENSGT00940000162980; -.
DR InParanoid; I3KI77; -.
DR OMA; LPRWASC; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF155; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H6; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 27..158
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 277..462
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 872 AA; 97076 MW; E1EEA75F6BF4548E CRC64;
MQENHKTGLC SYVTRISCKS FSLMLSSPTF KLFTYFLCLQ LKVTDYLVKC SVVSRYAVTT
VQSSVWNQLP ITKEAAFEVD LPSSAFISNF TITSSGKVYV AQVKERAAAR KIYDAAKKNT
TLQMLHLWFC REREIEKFRV AVSVPSGARM SFFLTYEELL QRRLGRYELT LGLRPSQLVQ
NLTLDVCIRE RTGISFLKVL PLRTSRAVTN TPSPECARVR YTPTLDQQKS ISSNGLNADF
IIQYDVDLKD LIGDVQVFDG YFVHYFAPRG LPVVPKDVIF VIDVSSSMIG NKIKQTKQAM
STILGDLREG DHFNIITFSD KVHTWKKGKT VRATRQNVWE AKEFVKRIIA EGWTNINAAL
LSAAQLVNPP SSGPSRRTSS HRVPLVIFLT DGEATIGVTS SETILSNAKK ALGSASLFGL
AFGDDADFLL LKRLALENRG VARMVYEDAD AALQLKGFYD EVASPLLSDI QLSYLDDQAF
DVTRSLFPNY FQGSELVVTG RVKTGVKDLK VLVSAIDSKQ QMKLENDVFI SQENGTTDSL
ECSGDLEGIS SFVHRLWAYF TIKELLLAKL NSTNPATQKL LTDKATNLSL KYNFVTPVTS
LVVVKPDEDE ATQSPTTPEP TTAATITTTA TTTATTKTSG AVDGDPHFVV QLAKLHQNLC
FTVDGRANDV LRLLEDPERS MQNGHLMGAP SKDGAEDRLR NYFDQLTISV VTGNSGDIMI
TLTLDAVVVE GEGRDTLPIN QQGSVTRQGV TVTVDNHQSC WIELAEGVQF LVLFHHYKHP
SYLQSAHLGF YITDGRGLSD STQGLLGAYT KASTENEYVV LFWYICYCVQ WFKKQLATTL
NFHFLISVIS VIERELFVLS LMSLKKKMTE LL
//
