ID   I3KIA1_ORENI            Unreviewed;       871 AA.
AC   I3KIA1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 73.
DE   SubName: Full=Nuclear factor of activated T cells 2 {ECO:0000313|Ensembl:ENSONIP00000020846.2};
GN   Name=NFATC2 {ECO:0000313|Ensembl:ENSONIP00000020846.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000020846.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000020846.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3KIA1; -.
DR   STRING; 8128.ENSONIP00000044656; -.
DR   Ensembl; ENSONIT00000020865.2; ENSONIP00000020846.2; ENSONIG00000016552.2.
DR   eggNOG; ENOG502QTJI; Eukaryota.
DR   GeneTree; ENSGT00940000156230; -.
DR   TreeFam; TF326480; -.
DR   Proteomes; UP000005207; Linkage group LG20.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd01178; IPT_NFAT; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR008366; NFAT.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR032397; RHD_dimer.
DR   InterPro; IPR011539; RHD_DNA_bind_dom.
DR   InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR   PANTHER; PTHR12533; NFAT; 1.
DR   PANTHER; PTHR12533:SF4; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2; 1.
DR   Pfam; PF16179; RHD_dimer; 1.
DR   Pfam; PF00554; RHD_DNA_bind; 1.
DR   PRINTS; PR01789; NUCFACTORATC.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS50254; REL_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          332..514
FT                   /note="RHD"
FT                   /evidence="ECO:0000259|PROSITE:PS50254"
FT   REGION          94..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          816..838
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        816..835
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   871 AA;  96185 MW;  9A0BDB2F5FB33738 CRC64;
     MFRETWRLAQ YHTMRSMDQD DSNLGPPKVF SPESEQAFPL EETLPYGIKS CSPAYSEHTE
     VLTGYENQEA RNYLDSTRPA ALSPRIEITP SREHYSHGRD SLQNHHLNIS PRPTLTVPGH
     ENLAYREPQC LSPASSNSST SWHSTENYSP WASPCVSPSS AQNPGDLCPR LQNIHTGSPR
     TSPGTSPRTS QGDDGLGPRS PSPRPGSRST SPQGKRTYDM YRNPGLIPGH RSRSPSPNNG
     HEDHNIGAHY THTSLTDAMN GFGTNHPNLV PTKIVKTSNQ VYTLYPENHG DGNYMVSCDQ
     DIKTKPAAEP FFVIPSIWPK PLVSSLCSIP VASLPPLEWP IPSRTDQYEL HIDVQPKPHH
     RAHYETEGSR GAVKAPTGGH PVVQLHGYRG KEPLGLQIFI GTADERILKP HAFYQVHRIT
     GKTVTTTSFE KIINGTKVLE IPLEPKNNMK AIIDCAGILK LRNADIELRK GETDVGRKNT
     RVRLVFRVHI PQPGGQHISL QVASHPIECS QRSAHELPMV EKQDMDSCSV LGGQQMILTG
     QNFSSDSKVI FMEKTQDGQQ IWEMEATVDK DKSQPSMLFV EVPPYRDASV CHPVKVNFYV
     INGKRKRSQP QHFTYTPLAC KNAAQPLFAP SIKTEPIDEY EAERMGFAMP QILGLSPHSY
     YHNPRGILHP DNGLVSGMAP CQRLSSSLPN QDARFQLQSP AIVYSRGGKS LSGSPAMWQT
     GGMMPDPHRS VLVHTGSPAQ SVGPVNAGQH PSIIQFSPTN HHLIRAGEPQ PLTGPQPDNQ
     QIIYCDSYSP QAAATHSPTP PQVAVTHPQH YPTVIQQQKG RTPAGTGQMD TSGDGQRRVT
     VKEENLDQAY LDDVNEIIRK DLTGVQARGQ T
//