ID I3KIM9_ORENI Unreviewed; 623 AA.
AC I3KIM9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Zinc finger FYVE domain-containing protein 1 {ECO:0000313|Ensembl:ENSONIP00000020974.2};
GN Name=LOC100694251 {ECO:0000313|Ensembl:ENSONIP00000020974.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000020974.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000020974.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3KIM9; -.
DR STRING; 8128.ENSONIP00000057114; -.
DR Ensembl; ENSONIT00000020993.2; ENSONIP00000020974.2; ENSONIG00000016650.2.
DR eggNOG; KOG1818; Eukaryota.
DR GeneTree; ENSGT00940000165302; -.
DR HOGENOM; CLU_020922_0_0_1; -.
DR TreeFam; TF323237; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15734; FYVE_ZFYV1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR042427; ZFYV1.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46624; AGAP002036-PA; 1.
DR PANTHER; PTHR46624:SF2; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1-RELATED; 1.
DR Pfam; PF01363; FYVE; 2.
DR SMART; SM00064; FYVE; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50178; ZF_FYVE; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 478..539
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 561..621
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
SQ SEQUENCE 623 AA; 69212 MW; AF911FBFB261FBC0 CRC64;
MSDILMKEMD SLSISPLKPE DRPDDGGRSF LLVDEQENLQ VRDEAEFVER LGCADVAGVK
VLSIFGNTGD GKSHTLNHVL FDGETVFYTS KSPSSCTVGV WAAYNPTLSL IALDTEGLLG
AAANQNQRMR LLLKVLAVSD IVVYRTRAER LHNDMFQFLS SASGAYLKHF TPELRALSTR
CGLDVPLSSL GPAVIIFQET THTQLLGQDS KMAGYADTLL QKRFHDLGLG TEAFSSVQYI
GTQTITPPTN YSGLLEAIKQ QVKNTHTRSP RQPAIVFHAL EALSERFCGE LSDEKMTLYS
FFPDEYFTCS ALCLSCNIRC KNGMNHLRDR VPHMADGLCQ YAHQYNNKVL ICKRCYEAGR
EVIVVPKTSA SSDNPWFGLA KYAWSGYVLE CASCGVIYRS RQYWMGNQDP ESGVVRSEVK
HVWEGSDTFL TSHQNAAQRV LDGMNYVIQS VSEYGTGPTK AVTGWITDQV APPYWRPNTE
ITACHGCQKE FKEAERKHHC RSCGEGFCHP CSSHRMPVPE RGWGSSPVRV CEACYRQGGP
PDTNSQGFVK DVARPDYWVP DQDIIKCNQC SKPFTPAMSK HHCRACGQGV CGPCSTHNKP
VPSRGWDHPV RVCDSCHART DSL
//
