ID I3KIX0_ORENI Unreviewed; 1552 AA.
AC I3KIX0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSONIP00000021065.2};
GN Name=ARAP1 {ECO:0000313|Ensembl:ENSONIP00000021065.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021065.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021065.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_013129311.1; XM_013273857.2.
DR Ensembl; ENSONIT00000021084.2; ENSONIP00000021065.2; ENSONIG00000016723.2.
DR GeneID; 100704703; -.
DR CTD; 116985; -.
DR GeneTree; ENSGT00940000157424; -.
DR HOGENOM; CLU_002900_0_0_1; -.
DR OrthoDB; 4835at2759; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08837; ArfGap_ARAP; 1.
DR CDD; cd13256; PH3_ARAP; 1.
DR CDD; cd13259; PH5_ARAP; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 3.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 4.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 5..69
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 483..575
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 590..679
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 685..799
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 893..1000
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1110..1286
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1318..1407
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1420..1532
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 64..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..219
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..266
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..328
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1552 AA; 175639 MW; 34F2D33A546A549C CRC64;
MSQSESCANV GEWLGVLRLE QYCDAFQSAG YATLQQCRSL TPEQLECIGI TLPGHQRRIL
ASLNKTHGNR DAHAVGPCER SEEKGRAEFL GADRPLPATP HEKSLLQDNV KQDGETMRPI
PRKREKPVPR ERQVSRLQES SGEGEKPVPG KRQMVPRNAE EKEKDGGLDG ERKKPVPKER
TKFRSTTPDN LDPSPPPALD TSLPPVPPRS TPNCPPQRFT LPPVQTSGSP KLERLEVRAP
ALQCRSVSPS STSAPPQPPS HPPDLPSTAN RPQTLAIQPN AQHLTIDGGR KSSPVSPIHS
PCSRNIPPLP PKAGIASKGP PPIPQRFPVQ SPRTHSPSPT KTGTDDTLRE QTPEIPPRIR
PPKIQESPQQ LTQPDIQPAL PARRIPQPPS EYMLATVNEN SNDYEEPDLF GPAGHRMNPP
ERDMSLQVPD YTKKRPSSLC SDDGVLDDYE YEGTLHSQQG SFYLPNTGVL ASTMKEDTSQ
LSAVIKMGWL DKNPPQGAIY YQRRWVKLDA DYLRYFDTDK DVYSKGIIST AFITNVTTVG
ELKFEVVTNN RTFIFRAESE AERNEWVTVL QDCTSGRQRH TVMNPGSPLA PDYQGYLELK
GLRSKLYTVV ASDKVFLYKN IDDYRIGLGI TSIEMNVGNI KVSDRRSFDL TTPYRIFSFI
AESEQMREQW VNAMRDAIGE ALSNSEVAER IWAESSNSLC ADCEASKPEW AAINLCVVVC
KQCAGEHRGL GPSISKVRSL KMDKKVWTEE LIQLFLVIGN ERANSFWAAN VPPSEALSPS
SCSEERRRFI SNKYRQGKYR RYHALYGNQM ELNHALCINV QCSDVLETLS LIFCGADVNC
SAGLDSQPTP LSLATAHSQP LQAELLNHNL NTELPRLEEV DAMDPEPYPL PPSVSHNGFL
FKTGSMARPV TERKAKEEFS RRWCTLNDGV FSYYESDKNS NPNGALKASE IVCLAVDNDD
KHGYDCTFEI YSESERLYLF GTDDSEVRSQ WVKSIAKTFI PVSAEPLLRL SFERIGKLMC
KDGLNLQRSK VGWFALEGSV LHVYLEGSQV EEIHLRKLNE LSIQQDNEVM VLVGKGRTLY
IEGKRKLDFS CWCTAIQAAA GSGGDTLHEQ QLTETDIPVI VDSCINYITQ CGMVSEGIYR
KSGVNSRVAA LCERFRRDAR SLCLREGEHQ VDDVSNTLKR FFRELDEGVF TKQEFQSWLS
TATIQDESTK ISEYKHLLNK LPHVNKATLQ ALINHLYCVQ HFSDENQMNN HNLAIVFGPT
LFQTDGKDYA AGRAIEDLIE HYKLIFEVDE QQLNKQIKVI EAIRQMRELK NPPSERGGDF
ICTVYLEEKA PSAEKHVKIP GSMTALELTL EILDQRNIPI KDKDYWSCWE ICCKEEMERP
LHYQERVLPI VHSVGTESHL LIKKHPAMEA ITLYLSSKPD ASKHGMIKFR EERSILGLGL
TSFHDRYFIL NYNSLRMYKD VRSNRPEREW PVKNLKVYLG IKKKLRPPTC WGLTVLYESK
KQEKPERQQW YLCCETQSEM REWYATFLSI QYDGNVWPQD GLQHKRFLKD FR
//