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Database: UniProt
Entry: I3KIX0_ORENI
LinkDB: I3KIX0_ORENI
Original site: I3KIX0_ORENI 
ID   I3KIX0_ORENI            Unreviewed;      1552 AA.
AC   I3KIX0;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   24-JAN-2024, entry version 70.
DE   SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSONIP00000021065.2};
GN   Name=ARAP1 {ECO:0000313|Ensembl:ENSONIP00000021065.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021065.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000021065.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   RefSeq; XP_013129311.1; XM_013273857.2.
DR   Ensembl; ENSONIT00000021084.2; ENSONIP00000021065.2; ENSONIG00000016723.2.
DR   GeneID; 100704703; -.
DR   CTD; 116985; -.
DR   GeneTree; ENSGT00940000157424; -.
DR   HOGENOM; CLU_002900_0_0_1; -.
DR   OrthoDB; 4835at2759; -.
DR   Proteomes; UP000005207; Linkage group LG14.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd08837; ArfGap_ARAP; 1.
DR   CDD; cd13256; PH3_ARAP; 1.
DR   CDD; cd13259; PH5_ARAP; 1.
DR   CDD; cd04385; RhoGAP_ARAP; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037858; RhoGAP_ARAP.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 3.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 5.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 5.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 4.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          5..69
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          483..575
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          590..679
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          685..799
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   DOMAIN          893..1000
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          1110..1286
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          1318..1407
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          1420..1532
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          64..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..139
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..219
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        252..266
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        267..289
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..328
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1552 AA;  175639 MW;  34F2D33A546A549C CRC64;
     MSQSESCANV GEWLGVLRLE QYCDAFQSAG YATLQQCRSL TPEQLECIGI TLPGHQRRIL
     ASLNKTHGNR DAHAVGPCER SEEKGRAEFL GADRPLPATP HEKSLLQDNV KQDGETMRPI
     PRKREKPVPR ERQVSRLQES SGEGEKPVPG KRQMVPRNAE EKEKDGGLDG ERKKPVPKER
     TKFRSTTPDN LDPSPPPALD TSLPPVPPRS TPNCPPQRFT LPPVQTSGSP KLERLEVRAP
     ALQCRSVSPS STSAPPQPPS HPPDLPSTAN RPQTLAIQPN AQHLTIDGGR KSSPVSPIHS
     PCSRNIPPLP PKAGIASKGP PPIPQRFPVQ SPRTHSPSPT KTGTDDTLRE QTPEIPPRIR
     PPKIQESPQQ LTQPDIQPAL PARRIPQPPS EYMLATVNEN SNDYEEPDLF GPAGHRMNPP
     ERDMSLQVPD YTKKRPSSLC SDDGVLDDYE YEGTLHSQQG SFYLPNTGVL ASTMKEDTSQ
     LSAVIKMGWL DKNPPQGAIY YQRRWVKLDA DYLRYFDTDK DVYSKGIIST AFITNVTTVG
     ELKFEVVTNN RTFIFRAESE AERNEWVTVL QDCTSGRQRH TVMNPGSPLA PDYQGYLELK
     GLRSKLYTVV ASDKVFLYKN IDDYRIGLGI TSIEMNVGNI KVSDRRSFDL TTPYRIFSFI
     AESEQMREQW VNAMRDAIGE ALSNSEVAER IWAESSNSLC ADCEASKPEW AAINLCVVVC
     KQCAGEHRGL GPSISKVRSL KMDKKVWTEE LIQLFLVIGN ERANSFWAAN VPPSEALSPS
     SCSEERRRFI SNKYRQGKYR RYHALYGNQM ELNHALCINV QCSDVLETLS LIFCGADVNC
     SAGLDSQPTP LSLATAHSQP LQAELLNHNL NTELPRLEEV DAMDPEPYPL PPSVSHNGFL
     FKTGSMARPV TERKAKEEFS RRWCTLNDGV FSYYESDKNS NPNGALKASE IVCLAVDNDD
     KHGYDCTFEI YSESERLYLF GTDDSEVRSQ WVKSIAKTFI PVSAEPLLRL SFERIGKLMC
     KDGLNLQRSK VGWFALEGSV LHVYLEGSQV EEIHLRKLNE LSIQQDNEVM VLVGKGRTLY
     IEGKRKLDFS CWCTAIQAAA GSGGDTLHEQ QLTETDIPVI VDSCINYITQ CGMVSEGIYR
     KSGVNSRVAA LCERFRRDAR SLCLREGEHQ VDDVSNTLKR FFRELDEGVF TKQEFQSWLS
     TATIQDESTK ISEYKHLLNK LPHVNKATLQ ALINHLYCVQ HFSDENQMNN HNLAIVFGPT
     LFQTDGKDYA AGRAIEDLIE HYKLIFEVDE QQLNKQIKVI EAIRQMRELK NPPSERGGDF
     ICTVYLEEKA PSAEKHVKIP GSMTALELTL EILDQRNIPI KDKDYWSCWE ICCKEEMERP
     LHYQERVLPI VHSVGTESHL LIKKHPAMEA ITLYLSSKPD ASKHGMIKFR EERSILGLGL
     TSFHDRYFIL NYNSLRMYKD VRSNRPEREW PVKNLKVYLG IKKKLRPPTC WGLTVLYESK
     KQEKPERQQW YLCCETQSEM REWYATFLSI QYDGNVWPQD GLQHKRFLKD FR
//
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