ID I3KJ88_ORENI Unreviewed; 547 AA.
AC I3KJ88;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Double-strand-break repair protein rad21 homolog {ECO:0000313|Ensembl:ENSONIP00000021183.2};
GN Name=LOC100698455 {ECO:0000313|Ensembl:ENSONIP00000021183.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021183.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021183.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the rad21 family.
CC {ECO:0000256|ARBA:ARBA00009870}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003439162.2; XM_003439114.4.
DR RefSeq; XP_019205547.1; XM_019350002.1.
DR AlphaFoldDB; I3KJ88; -.
DR STRING; 8128.ENSONIP00000021183; -.
DR Ensembl; ENSONIT00000021202.2; ENSONIP00000021183.2; ENSONIG00000016811.2.
DR GeneID; 100698455; -.
DR KEGG; onl:100698455; -.
DR CTD; 642636; -.
DR eggNOG; KOG1213; Eukaryota.
DR GeneTree; ENSGT00940000154655; -.
DR HOGENOM; CLU_015775_1_1_1; -.
DR InParanoid; I3KJ88; -.
DR OMA; RITRRAM; -.
DR OrthoDB; 5481351at2759; -.
DR TreeFam; TF101215; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0008278; C:cohesin complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd21792; Rad21_Rec8_M_NXP1-like; 1.
DR InterPro; IPR049589; NXP1_M-like.
DR InterPro; IPR039781; Rad21/Rec8-like.
DR InterPro; IPR006909; Rad21/Rec8_C_eu.
DR InterPro; IPR006910; Rad21_Rec8_N.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12585:SF19; DOUBLE-STRAND-BREAK REPAIR PROTEIN RAD21-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR12585; SCC1 / RAD21 FAMILY MEMBER; 1.
DR Pfam; PF04824; Rad21_Rec8; 1.
DR Pfam; PF04825; Rad21_Rec8_N; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 2..100
FT /note="Rad21/Rec8-like protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04825"
FT DOMAIN 496..545
FT /note="Rad21/Rec8-like protein C-terminal eukaryotic"
FT /evidence="ECO:0000259|Pfam:PF04824"
FT REGION 400..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 62121 MW; 9578FC919CE39C7C CRC64;
MMFYTQLFTS KRGSLAKIWL AAHWEKKLTK AHVFECNLET TIREIISPKV RIGLRTSGHL
LLGVVRIYSR KAKYLLADCS DALIKIKTAF RPGQTDLPVE GLEATIKAIT LVEDFTSFDP
QLPDPSDIDV VDHFSLNQCR SEEITLKEDF GNNFLNFADI GDERQIYHNA LMDVSFQSLA
QHGDAFGDED QGFDLLDFLT QSSDNAEATE FIQENPQNEN LPSSPLYDQQ EPICLADANR
TECMEVETPT ANQTTLLANE EAFALEPVPI TPNSERKKGK RKRKLVVDQT KELSNECIRK
QLSDFSDLVT PLDMAPPTVQ LMQWKESGGA DKLFAQPCST VLSLQIKELF ARSFFQVKRC
GVREDVEEMR HEEHKAQREL SALTTEVSVM DLSADPEKTH NTELTEHDHV NDSQRESYSQ
LAQDENRSEL THPSLPSEDS MFVHPPYLEH STQSTSLHTQ SMLSSQDFEE RRITRRAQKL
LNALKQSQHD SKDPTFSLQG ICEGSNRWQA ATTFFCFLVL KKQEVLRLCQ TAPYEDISAT
PGPKFYN
//
