ID I3KJQ1_ORENI Unreviewed; 1152 AA.
AC I3KJQ1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Neurofascin {ECO:0000313|Ensembl:ENSONIP00000021346.2};
GN Name=NFASC {ECO:0000313|Ensembl:ENSONIP00000021346.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021346.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021346.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR AlphaFoldDB; I3KJQ1; -.
DR STRING; 8128.ENSONIP00000038445; -.
DR Ensembl; ENSONIT00000021365.2; ENSONIP00000021346.2; ENSONIG00000016929.2.
DR eggNOG; KOG3513; Eukaryota.
DR GeneTree; ENSGT00940000157024; -.
DR HOGENOM; CLU_005756_1_1_1; -.
DR TreeFam; TF351098; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1152
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025542689"
FT TRANSMEM 1033..1054
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..121
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 126..233
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 247..336
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 341..428
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 434..520
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 524..607
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 618..713
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 718..811
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 816..920
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 924..1020
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1103..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 131032 MW; 62704811D57846EF CRC64;
MGTLVKPALL LLLWQSVGAL NVPLEVRQPP TIIKQSMKEH IVDPKGTMVI ECEAKGNPHP
IFSWRRNGKY FNVARDSQVS MRRRSGTLDI YARNNPEKYE AEYQCIASNQ YGSAYSHKII
LQLYRPPVWP REIVEPVVVS AGLPLVLSCD PPPGPPKPET YWMSSCSYAR PFNWPIQTAF
PTMQPVRQDR RVSMGVSGDL YFSNVLFNDS VVDYCCNARF PYKNVIQQKM PVVVKVLTTR
AVVEAAPTWL SPTGSSSSVL VLQGEELLLE CIAAGMPTPH ITWAKDGEDL QVTSRMKVKN
FNKMIQIPKA SFEDAGEYTC TAKNRLGYAE HTITVRVKAT PFWLEKPTNL ILAPEENGRL
VCRADGAPRP TISWFINGEP IETATPLPNR QVSGETLIFR SVTTENTAVY QCNASNQYGY
LLANAFINVL HATPRILGAR NEFIKVTEGS RTFLDCQYFG SPLPELRWSK YGQGNLEGNR
FKTHSNGTLE IKHIKIEDQG TYVCVVSNIA GRDEDQVRVE VKEPILIVTR PQSMKVMRAT
DVRLECGVKA DVTTPITTTW LKNKKHLTLG WRISMDESNL VITNVNTGDE GNYTCVIKSE
LEQKSASAHL MVMDRPNPPT NLELSDPYER TVRLSWVPGD SNHSPITGFL VQYDDDDWLP
GKWRNLSTYP GNLNSVILHL IPFTYYEFRV IAINEIGASR PSRPSKRFQT SGAPPDIIPK
NLKGVGTWRN NMEISWEPLT YREWNGPHLK YLVWWRRRDS REEWKNATTK WLKYYIYDAD
TFTPYEIKVQ AVNDFGLGPE SPVVIGYSGE GRPTTAPLNL RVSDIESTQV TLHWDPVTSD
TIMGELKEYK VYYWRDSSQL RWHWVDRGMK SKAFPINGPD PSGVLDDLIP YSNYKMYIVV
ANNRYEGPPS NNIHFSTPEG VPSAPRSFRI QQRHLDSIYV DWGLPAEPNG IITGYSLKYQ
TVNATRGEEL RVEELPPNVT SFSIRRYDRY TRYRFSVAAR TRLGIGEWHT EESPHYTTEI
YAQDQVDITT QGWFIGIMCA VALIVLILLI VCFIKRSRGG KYPVRDKKDI SLELVDDKDQ
EGSFDYRSLE RIARVSTLPY PRREEERGLQ RGQPSIEAMM KRSDSDDSLV EYGEGDHALQ
MEKGSTDSTW LE
//
