ID I3KJQ7_ORENI Unreviewed; 241 AA.
AC I3KJQ7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=GRB2-related adapter protein 2 {ECO:0000313|Ensembl:ENSONIP00000021352.1};
GN Name=LOC100710443 {ECO:0000313|Ensembl:ENSONIP00000021352.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021352.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021352.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013120406.1; XM_013264952.2.
DR RefSeq; XP_013120407.1; XM_013264953.2.
DR RefSeq; XP_013120408.1; XM_013264954.2.
DR RefSeq; XP_019215867.1; XM_019360322.1.
DR RefSeq; XP_019215868.1; XM_019360323.1.
DR AlphaFoldDB; I3KJQ7; -.
DR STRING; 8128.ENSONIP00000021352; -.
DR Ensembl; ENSONIT00000021371.2; ENSONIP00000021352.1; ENSONIG00000016932.2.
DR GeneID; 100710443; -.
DR KEGG; onl:100710443; -.
DR eggNOG; KOG3601; Eukaryota.
DR GeneTree; ENSGT00940000157307; -.
DR HOGENOM; CLU_073617_1_0_1; -.
DR InParanoid; I3KJQ7; -.
DR OMA; YIDIHIP; -.
DR OrthoDB; 25371at2759; -.
DR TreeFam; TF354288; -.
DR Proteomes; UP000005207; Linkage group LG6.
DR CDD; cd09941; SH2_Grb2_like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR043539; Grb2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46037:SF3; GRB2-RELATED ADAPTER PROTEIN 2; 1.
DR PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..56
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 58..164
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 184..241
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 154..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 241 AA; 27734 MW; BA59324BB2876369 CRC64;
MEATAKFDFE ANAEDDLSFK RGDCLKILQT SGNWYRAEHN GAMGFVPKNY IDIHIPSWYQ
ENTSRSDAQE ILMSQPVGAF LIRSSRKPAP GDFSISVRHP ADVQHFRVMR DSRGQYYLWS
EKFPSLNQLV EYYKKKSISK QSLLLLKETQ KEERGDSDKL LPPLPIFPRS DRAPSPAPRQ
RKTSHTTQVR ALYDFKAEEA DELEFSAGDI IEVLEVSDQT WWKGQLRGKK GLFPSNYTKP
I
//
