ID I3KJT1_ORENI Unreviewed; 1028 AA.
AC I3KJT1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=FERM domain containing 4Bb {ECO:0000313|Ensembl:ENSONIP00000021376.2};
GN Name=FRMD4B {ECO:0000313|Ensembl:ENSONIP00000021376.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021376.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021376.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3KJT1; -.
DR STRING; 8128.ENSONIP00000021376; -.
DR Ensembl; ENSONIT00000021395.2; ENSONIP00000021376.2; ENSONIG00000016949.2.
DR eggNOG; KOG3529; Eukaryota.
DR GeneTree; ENSGT01020000230354; -.
DR HOGENOM; CLU_003623_2_0_1; -.
DR InParanoid; I3KJT1; -.
DR OMA; PRENHNN; -.
DR TreeFam; TF328984; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13191; FERM_C_FRMD4A_FRMD4B; 1.
DR CDD; cd17200; FERM_F1_FRMD4B; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR021774; CUPID.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR047176; FRMD4A/B.
DR InterPro; IPR041785; FRMD4A/B_FERM_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46079:SF1; FERM DOMAIN-CONTAINING PROTEIN 4B; 1.
DR Pfam; PF11819; CUPID; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 46..348
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 568..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 852..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 403..437
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 517..544
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 585..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1028 AA; 116740 MW; 70648A4129416242 CRC64;
MPDAIVFKKI LLTHEYLDII VSCVYENLSQ TLNFLFYFPL QMTEGKLCQV HLLDDRKLEL
LVQPKLLSYE LLDLVSSHFN LKEKEFFGLA FFDDNGQCKW LQMDRRVLDH DFSKKPGPIA
LNFLVRFYVE NITQLKDIIT VELFYLNAKS AVYSGIIEVE SDNVFKLAAN ALQEAKGDYT
SDENTRADLK KLPTLPTKVL KEHPSLAYCE DRVIEYYKQL KGVSRGQAIV QYLTLVESLP
TYGVHYYEVK DKQGIPWWLG ISYKGIGQYD LQDKLKPRKL YQWKQLENLY FREKKFAVEV
NDPHRRAVTK RTFGQTGLLI HTWYASHSLI KTIWVMAISQ HQFYLDRKQS KAKLGTTRSL
EEIAMDLTEH GGAKINRLGD VGLKNNFITA SNGSLVSTGS ADSEMSEEQK KEKLAELRKK
EQEIQDILAK KTKELKKICL REAELTGKLP KEYPLSSGER PPQVRRRVGT AFKLDDLFPY
NEDPILRNLE SRFALQQKIV EAAKKLANEP ELCKTVKKKR RRNCLDAMQK LQQIEDEMNQ
YRIKKGKKPT QRASVIIADE LARSNCSSLS SLPLDDDDSD SLSQRPRSRS VQGSPQLSPM
RSLGAEFDLE RQASPRDNHH NKNHNRLAVD AQEASNYYQN PREVSSTHSS PYKTLPRPPR
DPRSMPPTPV MTRNAYSSSQ LRLEGSPHCF RHRSGSLESQ PRLRKDRDSE KPVFILSPAH
RSNSTEVLED CSSYTSQSSL DYCGAANSHY STLDSRTSTM HRLHRKVEVY GNTGSMPNLV
QHHSGCSYSC EASPHYAPSA YYVAGYPCPD MEPYANGAYV YENEVEGHYN VNPSYQMNGY
HGHDRFRHYS SDGADNLSQN PYATVRPPRT REGPRNELLA KNMQKALVAE HLRGWYHRNR
GHREGGRGLL AGYDFDSGSQ LSLGYQTMPA AFSHSSRATS FSSVSSAEST GNWRNQLAVG
LTEFDAPDTP QYPHPGASAS LYNRSPTHNR NSPENKESDT MPKKCESVDV VGAEATSAAE
PSDNLSST
//
