ID I3KK56_ORENI Unreviewed; 848 AA.
AC I3KK56;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN Name=dll1 {ECO:0000313|Ensembl:ENSONIP00000021501.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021501.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021501.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; I3KK56; -.
DR STRING; 8128.ENSONIP00000030349; -.
DR Ensembl; ENSONIT00000021520.2; ENSONIP00000021501.2; ENSONIG00000017050.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000159781; -.
DR TreeFam; TF351835; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044:SF380; DELTA-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 554..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 174..218
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 285..323
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 325..361
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 363..400
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 402..438
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 444..480
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 482..518
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 684..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 176..185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 189..201
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 209..218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 313..322
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 351..360
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 390..399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 428..437
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 470..479
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 508..517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 848 AA; 93124 MW; E61BB8BBA54A91DA CRC64;
ISFTFLLVDQ SAGDYFVLCS GVFELKLQEF LNKKGITGNA NCCPTHLQGQ QQCECKTFFR
VCLKHYQANV SPEPPCTYGG TVTPVLGSNS FQVPETNADS FTNPIRFSFG FTWPGTFSLI
IEALHTDSLD DLTTDNPERL ISRIATQRHL SVGEEWFSDV QTAGKTELRY SYRFLCDEYY
YGEGCSVFCR PRDDAFGHFT CGERGEIICN SGWKGHYCTE PICLPGCDEE HGFCDKPGEC
KCRVGFSGRY CDDCIRYPGC LHGTCQQPWQ CNCQEGWGGL FCNQDLNYCT HHKPCLNGAT
CTNTGQGSYT CSCLPGYTGA SCEIQVSECS GSPCRNGGSC TDNDNGYKCT CPPGFYGNNC
ELSANTCADG PCFNSGHCVD NPEGGYFCQC PTGYAGFNCE KKIDHCSSNP CLNGAECVDL
VNSYLCQCSE GFSGPNCEES GSSVSGYCLS FPCQNGGTCQ ETGNGYTCSC PPGYTGKNCS
SPVSRCKHNP CHNGATCHEQ GSRYMCACVP GYGGHNCQFL LPEIPRGHPV VDGPDRIYSG
SENPDDVEDD NGGFPWVAVW AGVFLVLVIL IGCSMLVVYI RVKLQERHSH HSDSVHSDSH
ETMNNLTTTN NCLRSDKELG VLMTTSIKNT NKKADYHSDL TGSLGGLSGI GGLNGTEKNG
FKSRYPSVEY NLVHELQPEE LPPCKEEGHQ EPEAKCEMLD ESDTEERYRK RKNRYTTNQN
TLLMVGIISC RCPLNHCESI CCMKDSISEF LCPFLSHSDA SEKKPVDESP SCSEAKYQSS
TDLNCHAASD LKYQSTSDVK FQSTSDVEYS GPSDSRYQCT SDTKYQSVYV ISDQKDECII
ATEVSTQK
//
