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Database: UniProt
Entry: I3KKA2_ORENI
LinkDB: I3KKA2_ORENI
Original site: I3KKA2_ORENI 
ID   I3KKA2_ORENI            Unreviewed;      2837 AA.
AC   I3KKA2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   10-FEB-2021, entry version 44.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000021547};
GN   Name=cenpf {ECO:0000313|Ensembl:ENSONIP00000021547};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021547, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000021547}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
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DR   RefSeq; XP_005459003.1; XM_005458946.3.
DR   RefSeq; XP_005459004.1; XM_005458947.3.
DR   STRING; 8128.ENSONIP00000021547; -.
DR   Ensembl; ENSONIT00000021566; ENSONIP00000021547; ENSONIG00000017088.
DR   GeneID; 100698969; -.
DR   KEGG; onl:100698969; -.
DR   CTD; 1063; -.
DR   eggNOG; ENOG502QVMD; Eukaryota.
DR   GeneTree; ENSGT00730000111187; -.
DR   OrthoDB; 205405at2759; -.
DR   TreeFam; TF101133; -.
DR   Proteomes; UP000005207; Linkage group LG1.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR   GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 3.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 2.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          1..306
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1809..1951
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2047..2189
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2741..2785
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          50..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          484..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          547..586
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1062..1082
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1544..1578
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1637..1657
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2060..2089
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2243..2272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2357..2431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2560..2580
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2654..2755
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2785..2837
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          162..196
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          684..714
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          719..760
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          779..814
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          818..968
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          979..1041
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1095..1122
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1130..1220
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1231..1353
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1361..1395
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1403..1437
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1466..1497
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1502..1529
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1687..1791
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1813..1861
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1890..1910
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1932..1966
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        50..65
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..158
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..281
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        500..517
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        556..586
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2060..2086
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2251..2272
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2357..2420
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2668..2688
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2689..2704
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2705..2724
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2740..2754
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2808..2837
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2837 AA;  325612 MW;  3DD30A2EB5B5CAAF CRC64;
     MSWAVEEWKD GLPGKALQKI QEMEVQLDKM KKEKTQKQFQ LDSLEAALQK QKQKVDSERT
     ETSALKRENQ SLVESCDSLE KARQKVVHDL GVKEQQVSYL EGQLNSCRKT IERLEQELKK
     HKNELDRSQP AGSSSLSSSS CELQTYATPQ KSFQTPASIP AYRQHDNRLE ELQEKYNQEV
     EERKRLESEL KVFQVKLLNQ SSVSVSHKDI AARQAGSSIF PWQQQDSAHC RQSQDIMETP
     LKRRGTSLWD AHEETPIKPS QRMSSSRAAP SPSGSSQQME QLKTLNQELR GRVSELERNL
     ANQEKEIRNQ ASKLQELQTQ LNQTRKDLSE QGRDLAKTKH ELSQATDRHQ QIESKCSSLE
     QKLKQVTEEM SCQRHNAESC RRALEQKLKD QERDSQKELA QLQSSHHALD QQLNQTRTKL
     TQEIQQAKKD HNILQADMEK MCFQKKQMEK EMEEQKQKLL RSEQSLQACQ TKEQDLRKKM
     EELQKEKNSM TVQLDQSNRR LSQLEEEKKS SDQSLKRTQG LLDDLKAKSE GQVEELKKLQ
     CKLEQQTQTS AREQENFKKT LSDAETRNDR SQNELQKQKQ ESERLSNRVT VLEKESQELK
     SNFSASQNEC KELKREHQAL LDWKNEKETL INETEAVQKE LTDKITSLES SLGSLNEAND
     ELQKKLTCVE GEKASLSAHI DSLKGELLNK CTDLEEKAHQ YKELQSQFSE AGQKHAKDLE
     NIGVQVAQLE AQVKDLELRL QKEITRAELA ERMNTDLQDE HKATCDLVSS KEQLVELGRA
     EISQLRESLA QTIAQQEEQN ARLAEEKAAL LKQCEESVSA KAEETEHIKL QLEEAQQELL
     LTKNQISSLE QLLKVQEQLG AELQKQIKAM TEREEEQTRM YEKKSEELKQ LEMDLSDQRK
     QTEEKEKQLR EAEVQISSVE KQKAELENAI QDLKKEAEII QHSQTEKINS LLEQISSLEE
     KVDVNKDAAE KLPVLKNELD VATQSNADLK KSLEALEKNH SSTIEMKSNL ESTLAEKMNL
     ISALENEVKD LTEKMGKESE RHALEIENFL KKEKSLDEQL EATKKSVSAA KAESSSRREE
     IRTMKATLSA ASRGLEERDN TIKGLKEKLN KAEAEQTKTS ELLKEKVVAM NKIKVQLEML
     QMDLEDNETA MTSFDSQVEQ LKGTIESLEA MLAQNQTQMS EMEAMLDEGR AQVSVLEARL
     DEVQSQNSLL ESKYVTAKEE LFERTCEITR LEEEAIRRHE LEESVATLEA KLSHMTQDNE
     KLETTLRETI QDKERSLNQL LQEKNSLETS MKQLMNDKEQ VESEMVHVNA EKKRLEVTVD
     ALSEENKQLQ SNIERLTEEK QQTEAKINEI TARKHEAGSA LSQLTEAKAQ VDDILKKTNE
     ENVQLAEKLH ASTSEKNDLV TNLNQVVEEK VQLELSYNQL SEENIKLQSS VNQITEKKLQ
     LQELIKGHGD EVASLREENE CIQHSLLTSE QECQRLKEQL ELMEERTEET NKEQGERFTA
     EQAELHQKLA GLQKELSVFK QQYESLLEQV GQQHSLIQQL SEFKSPTDRN SHMEEAETDA
     EAAAESQVEP AGNSSLCTSS ETLPVEEELM VSEPTEFPDA FSEAKLVFKV DATEQEVTQE
     QPEEGGEAFV ADVEETKTNE EEQLLPEQVS EESSNSRDVL VDEPVIYDVS PQPSSFSEKR
     DMKSCESSLV NDELERYKEM IRKQENELET LRSEFDLLSS DLELRKELTS ELEVQVQNLE
     KKVHAAEEEA HSAACQLKIA LDSKKSLSDE LTQLSEEKET LTLQLQTTKC QLTDVMEMLE
     GLEMAKGGWD EKFLQQESEL KRVRSEKANL EQHILGMESE LETMQAEGAR LKDEMETQRR
     IFSGMEQKIE TLITETTQLR SELVSCTEER DELSQSLSHW REKVHSLEKN NCDTRNLISI
     LEDDIRAGRK EYEALQSSTD KLKTERQQLV EQVKELEQTI SQHCGEREEL IGHLNQIKED
     HSSSSQNTES MAGKIKALEG EVIRLSQSLE SSLLEKGEIA SRLNSTQDEV QQMRTGIEKL
     QVRIESDERK KKKMGELLKA AQRKSDSLQD RIDSLEREKE DVEQSLEEAV LQTEMAKAEL
     EEERRMVEEE KKELSAKISE LSTTLENLRS EKEHMERQLE IKNREIEELK AAKEELERGL
     EKAEAERKEE EERQKCRLEE LEKEMKGEAE RQIRVLDDLQ AQLEASRQRE ISLEQKSTEE
     EAEKERMQAL LVQLEEEKKH LLNSLQESQT EAERLRTHGE EWETERNSLR TQTEALEEEI
     EELKTLIKAT EDKMEVLEKE KEEDRDQKQA LERSVSSLIA EKEQIEGENG RFLQEKEELR
     TALLSLEQER DKLRSSLLSV EEEKERLDQE RSALASEREE LQSSLSVLDK EKHDLQQKLS
     FLNQEKAREE EEKQKIEAEK QELQSSVSLM EEEKKNLSSA LLSLEQEKEK LAEEHEHLKT
     AVSSMEKELE THKVSVSQLS EQVSELTSRA ARLTKDKDSA LSKMSLWMKT CKQLEQEKEM
     MLNGSGAGKS SEEGQTELTQ LRKEAEKLKK EVEDLKSALE QKMSEAEERL MESQEKDQEV
     NKLSAALDGK RKELEETVKE LEEMKTDLEE VNKLLEEKSK EADESMEKYC SLMLEVHKLE
     KTNEALKTRL ELIGASQNAN DGHSSSTEGR QRSGRKSSTR HQELKIDDNT ENMAPSSTQR
     SPPGSGKRGH REISNRDGAQ EALHNVTKRI KANAMTTPKS RPEQEDEEFR PEGLPELVQR
     GFADIPLGEA SPFIIRRTTV RRCSPRLAAK QTASDGKGLG PIPLQSPSAA MATDTANKTP
     EKQLREQTQQ GDNCHVQ
//
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