ID I3KKA2_ORENI Unreviewed; 2837 AA.
AC I3KKA2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 10-FEB-2021, entry version 44.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000021547};
GN Name=cenpf {ECO:0000313|Ensembl:ENSONIP00000021547};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021547, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021547}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2012) to UniProtKB.
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DR RefSeq; XP_005459003.1; XM_005458946.3.
DR RefSeq; XP_005459004.1; XM_005458947.3.
DR STRING; 8128.ENSONIP00000021547; -.
DR Ensembl; ENSONIT00000021566; ENSONIP00000021547; ENSONIG00000017088.
DR GeneID; 100698969; -.
DR KEGG; onl:100698969; -.
DR CTD; 1063; -.
DR eggNOG; ENOG502QVMD; Eukaryota.
DR GeneTree; ENSGT00730000111187; -.
DR OrthoDB; 205405at2759; -.
DR TreeFam; TF101133; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 3.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 2.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 1..306
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1809..1951
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2047..2189
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2741..2785
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 50..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1544..1578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1637..1657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2060..2089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2243..2272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2357..2431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2560..2580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2654..2755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2785..2837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 162..196
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 684..714
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 719..760
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 779..814
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 818..968
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 979..1041
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1095..1122
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1130..1220
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1231..1353
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1361..1395
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1403..1437
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1466..1497
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1502..1529
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1687..1791
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1813..1861
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1890..1910
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1932..1966
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 50..65
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..158
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..281
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..517
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..586
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2060..2086
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2251..2272
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2357..2420
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2668..2688
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2689..2704
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2705..2724
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2740..2754
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2808..2837
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2837 AA; 325612 MW; 3DD30A2EB5B5CAAF CRC64;
MSWAVEEWKD GLPGKALQKI QEMEVQLDKM KKEKTQKQFQ LDSLEAALQK QKQKVDSERT
ETSALKRENQ SLVESCDSLE KARQKVVHDL GVKEQQVSYL EGQLNSCRKT IERLEQELKK
HKNELDRSQP AGSSSLSSSS CELQTYATPQ KSFQTPASIP AYRQHDNRLE ELQEKYNQEV
EERKRLESEL KVFQVKLLNQ SSVSVSHKDI AARQAGSSIF PWQQQDSAHC RQSQDIMETP
LKRRGTSLWD AHEETPIKPS QRMSSSRAAP SPSGSSQQME QLKTLNQELR GRVSELERNL
ANQEKEIRNQ ASKLQELQTQ LNQTRKDLSE QGRDLAKTKH ELSQATDRHQ QIESKCSSLE
QKLKQVTEEM SCQRHNAESC RRALEQKLKD QERDSQKELA QLQSSHHALD QQLNQTRTKL
TQEIQQAKKD HNILQADMEK MCFQKKQMEK EMEEQKQKLL RSEQSLQACQ TKEQDLRKKM
EELQKEKNSM TVQLDQSNRR LSQLEEEKKS SDQSLKRTQG LLDDLKAKSE GQVEELKKLQ
CKLEQQTQTS AREQENFKKT LSDAETRNDR SQNELQKQKQ ESERLSNRVT VLEKESQELK
SNFSASQNEC KELKREHQAL LDWKNEKETL INETEAVQKE LTDKITSLES SLGSLNEAND
ELQKKLTCVE GEKASLSAHI DSLKGELLNK CTDLEEKAHQ YKELQSQFSE AGQKHAKDLE
NIGVQVAQLE AQVKDLELRL QKEITRAELA ERMNTDLQDE HKATCDLVSS KEQLVELGRA
EISQLRESLA QTIAQQEEQN ARLAEEKAAL LKQCEESVSA KAEETEHIKL QLEEAQQELL
LTKNQISSLE QLLKVQEQLG AELQKQIKAM TEREEEQTRM YEKKSEELKQ LEMDLSDQRK
QTEEKEKQLR EAEVQISSVE KQKAELENAI QDLKKEAEII QHSQTEKINS LLEQISSLEE
KVDVNKDAAE KLPVLKNELD VATQSNADLK KSLEALEKNH SSTIEMKSNL ESTLAEKMNL
ISALENEVKD LTEKMGKESE RHALEIENFL KKEKSLDEQL EATKKSVSAA KAESSSRREE
IRTMKATLSA ASRGLEERDN TIKGLKEKLN KAEAEQTKTS ELLKEKVVAM NKIKVQLEML
QMDLEDNETA MTSFDSQVEQ LKGTIESLEA MLAQNQTQMS EMEAMLDEGR AQVSVLEARL
DEVQSQNSLL ESKYVTAKEE LFERTCEITR LEEEAIRRHE LEESVATLEA KLSHMTQDNE
KLETTLRETI QDKERSLNQL LQEKNSLETS MKQLMNDKEQ VESEMVHVNA EKKRLEVTVD
ALSEENKQLQ SNIERLTEEK QQTEAKINEI TARKHEAGSA LSQLTEAKAQ VDDILKKTNE
ENVQLAEKLH ASTSEKNDLV TNLNQVVEEK VQLELSYNQL SEENIKLQSS VNQITEKKLQ
LQELIKGHGD EVASLREENE CIQHSLLTSE QECQRLKEQL ELMEERTEET NKEQGERFTA
EQAELHQKLA GLQKELSVFK QQYESLLEQV GQQHSLIQQL SEFKSPTDRN SHMEEAETDA
EAAAESQVEP AGNSSLCTSS ETLPVEEELM VSEPTEFPDA FSEAKLVFKV DATEQEVTQE
QPEEGGEAFV ADVEETKTNE EEQLLPEQVS EESSNSRDVL VDEPVIYDVS PQPSSFSEKR
DMKSCESSLV NDELERYKEM IRKQENELET LRSEFDLLSS DLELRKELTS ELEVQVQNLE
KKVHAAEEEA HSAACQLKIA LDSKKSLSDE LTQLSEEKET LTLQLQTTKC QLTDVMEMLE
GLEMAKGGWD EKFLQQESEL KRVRSEKANL EQHILGMESE LETMQAEGAR LKDEMETQRR
IFSGMEQKIE TLITETTQLR SELVSCTEER DELSQSLSHW REKVHSLEKN NCDTRNLISI
LEDDIRAGRK EYEALQSSTD KLKTERQQLV EQVKELEQTI SQHCGEREEL IGHLNQIKED
HSSSSQNTES MAGKIKALEG EVIRLSQSLE SSLLEKGEIA SRLNSTQDEV QQMRTGIEKL
QVRIESDERK KKKMGELLKA AQRKSDSLQD RIDSLEREKE DVEQSLEEAV LQTEMAKAEL
EEERRMVEEE KKELSAKISE LSTTLENLRS EKEHMERQLE IKNREIEELK AAKEELERGL
EKAEAERKEE EERQKCRLEE LEKEMKGEAE RQIRVLDDLQ AQLEASRQRE ISLEQKSTEE
EAEKERMQAL LVQLEEEKKH LLNSLQESQT EAERLRTHGE EWETERNSLR TQTEALEEEI
EELKTLIKAT EDKMEVLEKE KEEDRDQKQA LERSVSSLIA EKEQIEGENG RFLQEKEELR
TALLSLEQER DKLRSSLLSV EEEKERLDQE RSALASEREE LQSSLSVLDK EKHDLQQKLS
FLNQEKAREE EEKQKIEAEK QELQSSVSLM EEEKKNLSSA LLSLEQEKEK LAEEHEHLKT
AVSSMEKELE THKVSVSQLS EQVSELTSRA ARLTKDKDSA LSKMSLWMKT CKQLEQEKEM
MLNGSGAGKS SEEGQTELTQ LRKEAEKLKK EVEDLKSALE QKMSEAEERL MESQEKDQEV
NKLSAALDGK RKELEETVKE LEEMKTDLEE VNKLLEEKSK EADESMEKYC SLMLEVHKLE
KTNEALKTRL ELIGASQNAN DGHSSSTEGR QRSGRKSSTR HQELKIDDNT ENMAPSSTQR
SPPGSGKRGH REISNRDGAQ EALHNVTKRI KANAMTTPKS RPEQEDEEFR PEGLPELVQR
GFADIPLGEA SPFIIRRTTV RRCSPRLAAK QTASDGKGLG PIPLQSPSAA MATDTANKTP
EKQLREQTQQ GDNCHVQ
//
