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Database: UniProt
Entry: I3KKA3_ORENI
LinkDB: I3KKA3_ORENI
Original site: I3KKA3_ORENI 
ID   I3KKA3_ORENI            Unreviewed;      2339 AA.
AC   I3KKA3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   07-OCT-2020, entry version 45.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000021548};
GN   Name=cenpf {ECO:0000313|Ensembl:ENSONIP00000021548};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021548, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000021548}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
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DR   Ensembl; ENSONIT00000021567; ENSONIP00000021548; ENSONIG00000017088.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_000551_0_0_1; -.
DR   InParanoid; I3KKA3; -.
DR   OMA; YNAQLVQ; -.
DR   Proteomes; UP000005207; Linkage group LG1.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR   GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 4.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 2.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          6..259
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1380..1522
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          1618..1754
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2227..2271
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          72..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          500..540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          876..896
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1808..1837
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1925..1996
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2140..2236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          119..149
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          637..667
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          672..713
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          732..782
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          793..855
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          909..936
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          944..964
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          984..1011
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1038..1114
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1122..1156
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1164..1198
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1227..1254
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1286..1362
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1384..1481
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1503..1537
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1594..1663
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2077..2114
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        211..234
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..441
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..470
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..540
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1816..1837
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1925..1985
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2154..2174
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2175..2190
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2191..2210
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2339 AA;  269211 MW;  6BAFF78318BA8F53 CRC64;
     MSLFLQVDSE RTETSALKRE NQSLVESCDS LEKARQKVVH DLGVKEQQVS YLEGQLNSCR
     KTIERLEQEL KKHKNELDRS QPAGSSSLSS SSCELQTYAT PQKSFQTPAS IPAYRQHGIK
     ILEELQEKYN QEVEERKRLE SELKVFQVKL LNQSSVSVSH KDIAARQAGS SIFPWQQQDS
     AHCRQSQDIM ETPLKRRGTS LWDAHEETPI KPSQRMSSSR AAPSPSGSSQ QMEQLKTLNQ
     ELRGRVSELE RNLANQEKEI RNQASKLQEL QTQLNQTRKD LSEQGRDLAK TKHELSQATD
     RHQQIESKCS SLEQKLKQVT EEMSCQRHNA ESCRRALEQK LKDQERDSQK ELAQLQSSHH
     ALDQQLNQTR TKLTQEIQQA KKDHNILQAD MEKMCFQKKQ MEKEMEEQKQ KLLRSEQSLQ
     ACQTKEQDLR KKMEELQKEK NSMTVQLDQS NRRLSQLEEE KKSSDQSLKR TQGLLDDLKA
     KSEGQVEELK KLQCKLEQQT QTSAREQENF KKTLSDAETR NDRSQNELQK QKQESERLSN
     RVTVLEKESQ ELKSNFSASQ NECKELKREH QALLDWKNEK ETLINETEAV QKELTDKITS
     LESSLGSLNE ANDELQKKLT CVEGEKASLS AHIDSLKGEL LNKCTDLEEK AHQYKELQSQ
     FSEAGQKHAK DLENIGVQVA QLEAQVKDLE LRLQKEITRA ELAERMNTDL QDEHKATCDL
     VSSKEQLVEL GRAEISQLRE SLAQTIAQQE EQNARWDQTE KINSLLEQIS SLEEKVDVNK
     DAAEKLPVLK NELDVATQSN ADLKKSLEAL EKNHSSTIEM KSNLESTLAE KMNLISALEN
     EVKDLTEKMG KESERHALEI ENFLKKEKSL DEQLEATKKS VSAAKAESSS RREEIRTMKA
     TLSAASRGLE ERDNTIKGLK EKLNKAEAEQ TKTSELLKEK VVAMNKIKVQ LEMLQMDLED
     NETAMTSFDS QVEQLKGTIE SLEVSVLEAR LDEVQSQNSL LESKYVTAKE ELFERTCEIT
     RLEEEAIRRH ELEEKRSLNQ LLQEKNSLET SMKQLMNDKE QVESEMVHVN AEKKRLEVTV
     DALSEENKQL QSNIERLTEE KQQTEAKINE ITARKHEAGS ALSQLTEAKA QVDDILKKTN
     EENVQLAEKL HASTSEKNDL VTNLNQVVEE KVQLELSYNQ LSEENIKLQS SVNQITEKKL
     QLQELIKGHG DEVASLREEN ECIQHSLLTS EQECQRLKEQ LELMEERTEE TNKEQYVYLA
     VSALMFLRLN INIQIAFRHI CPSTESSLVN DELERYKEMI RKQENELETL RSEFDLLSSD
     LELRKELTSE LEVQVQNLEK KLTQLSEEKE TLTLQLQTTK CQLTDVMEML EGLEMAKGGW
     DEKFLQQESE LKRVRSEKAN LEQHILGMES ELETMQAEGA RLKDEMETQR RIFSGMEQKI
     ETLITEVSKL RSELVSCTEE RDELSQSLSH WREKVHSLEK NNCDTRNLIS ILEDDIRAGR
     KEYEALQSST DKLKTERQQL VEQVKELEQT ISQHCGEREE LIGHLNQIKE DHSSSSQNTE
     SMAGKIKALE GEVIRLSQSL ESSLLEKGEI ASRLNSTQDE VQQMRTGIEK LQVRIESDER
     KKKKMGELLK AAQRKSDSLQ DRIDSLEREK EDVEQSLEEA VLQVFSLTNI QKDNDCILLI
     AKISELSTTL ENLRSEKEHM ERQLEIKNRE IEELKAAKEE LERGLEKAEA ERKEEEERQK
     CRLEELEKEM KGEAERQIRV LDDLQAQLEA SRQREISLEQ KSTEEEAEKE RMQALLVQLE
     EEKKHLLNSL QESQTEAERL RTHGEEWETE RNSLRTQTEA LEEEIEELKT LIKATEDKME
     VLEKEKEEDR DQKQALERSV SSLIAEKEQI EGENGRFLQE KEELRTALLS LEQERDKLRS
     SLLSVEEEKE RLDQERSALA SEREELQSSL SVLDKEKHDL QQKLSFLNQE KAREEEEKQK
     IEAEKQELQS SVSLMEEEKK NLSSALLSLE QEKEKLAEEH EHLKTAVSSM EKELETHKLT
     SRAARLTKDK DSALSKMSLW MKTCKQLEQE KEMMLNGSGL EETVKELEEM KTDLEEVNKL
     LEEKSKEADE SMEKYCSLML EVHKLEKTNE ALKTRLELIG ASQNANDGHS SSTEGRQRSG
     RKSSTRHQEL KIDDNTENMA PSSTQRSPPG SGKRGHREIS NRDGAQEALH NVTKRIKANA
     MTTPKSRPEQ EDEEFRPEGL PELVQRGFAD IPLGEASPFI IRRTTVRRCS PRLAAKQTAS
     DGKVSNAGIY LCFFTDAARC SVFATLAPNM STQCPAPLVP YKLLSRQVRS VKQQAIKRL
//
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