ID I3KKU8_ORENI Unreviewed; 628 AA.
AC I3KKU8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Nuclear receptor subfamily 2 group C member 2 {ECO:0000313|Ensembl:ENSONIP00000021743.2};
GN Name=nr2c2 {ECO:0000313|Ensembl:ENSONIP00000021743.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021743.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021743.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000256|ARBA:ARBA00006421}.
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DR AlphaFoldDB; I3KKU8; -.
DR STRING; 8128.ENSONIP00000021743; -.
DR Ensembl; ENSONIT00000021762.2; ENSONIP00000021743.2; ENSONIG00000017240.2.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000158393; -.
DR HOGENOM; CLU_007368_16_2_1; -.
DR InParanoid; I3KKU8; -.
DR OMA; SVTEHIC; -.
DR TreeFam; TF316650; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06967; NR_DBD_TR2_like; 1.
DR CDD; cd06952; NR_LBD_TR2_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR048245; NR2C1/2-like_DBD.
DR InterPro; IPR048246; NR2C1/2-like_LBD.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24083:SF48; NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 2; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 134..209
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 367..615
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 628 AA; 69627 MW; 9721F5E3736BF41A CRC64;
MKCICVSSSP SDSVMSESPQ RFQVISTEPS TPQRIQIVTD QQTGQKIQIV TAMNPSSAPK
QQFILTTADS SGAGKVILAS PDSHNAKQLI FTAADSLVPG RIQVHFPLNT IVTDPVSMER
LLGQSGDLSR PQPVEYCVVC GDKASGRHYG AVSCEGCKGF FKRSVRKNLT YSCRSKQDCV
INKHHRNRCQ FCRLRKCLKM GMKTESVQSE RKPIDIVPRE RHANCAASTQ KIYIRKDLNS
PLIATPTFIS DTETDGSRSS LLDQGMLVNI QQPVIQSDGT LVLATDSKMD CGQGDLGTLA
NVVTSLANLS DSLKENLNNG DTSDSQHEEQ SASEITRAFD TLAKVFNPPE VGVEDSLTDK
SQCVSGTTIQ LIGRDQETPI IEVEGPLLTD SHVSFKLTMP SPMPEYLNVH YICESASRLL
FLSMHWARSI PAFSALGQEA NTSLVRACWN ELFTLGLAQC AHVMNLSTIL AAIINHLQSS
IQDGMDHRPH KLSGERVKQV MEHIWKFQEF CNSMTRLETD SYEYAYLKAI VLFSPDHPGV
DSSGQIEKFQ EKALMELQDY VQKTYPDDTY RLTRILTRLP ALRLMNSSIT EELFFTGLIG
NVSIDSIIPY ILKMETAEYN SQDSDSTE
//
