ID I3KLN8_ORENI Unreviewed; 367 AA.
AC I3KLN8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Transmembrane protein 129 {ECO:0000313|Ensembl:ENSONIP00000022033.1};
GN Name=tmem129 {ECO:0000313|Ensembl:ENSONIP00000022033.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000022033.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000022033.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM129 family.
CC {ECO:0000256|ARBA:ARBA00007332}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003458154.1; XM_003458106.4.
DR AlphaFoldDB; I3KLN8; -.
DR STRING; 8128.ENSONIP00000022033; -.
DR Ensembl; ENSONIT00000022052.2; ENSONIP00000022033.1; ENSONIG00000017472.2.
DR GeneID; 100706875; -.
DR KEGG; onl:100706875; -.
DR CTD; 92305; -.
DR eggNOG; KOG3899; Eukaryota.
DR GeneTree; ENSGT00390000013284; -.
DR HOGENOM; CLU_048119_1_0_1; -.
DR InParanoid; I3KLN8; -.
DR OMA; FCVLDVC; -.
DR OrthoDB; 2878268at2759; -.
DR TreeFam; TF314487; -.
DR Proteomes; UP000005207; Linkage group LG2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR InterPro; IPR018801; TM129.
DR PANTHER; PTHR31322; E3 UBIQUITIN-PROTEIN LIGASE TM129; 1.
DR PANTHER; PTHR31322:SF2; E3 UBIQUITIN-PROTEIN LIGASE TM129; 1.
DR Pfam; PF10272; Tmpp129; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 367 AA; 41783 MW; A13591DA00F5FD1E CRC64;
MESPELSFTL AYIVLSFCFV FTPTEFRSAG LTVQNLFSSW LGSEDVGFIQ YHIRRTSITI
LVHSALPLGY YMGMCVAAPE KNLGYIYQVS DNWRAFLLLS LCLQLVSWII VFYWSRGRWH
NHPISKMLQA HVQPPFSSWG SVAVSINTEF RHIDKFATGA PGARVIVTDT WVLKVTTYHI
YMALQRDCHV TVTESTQHHL NPDSASPTEI LTLRVDSINP AVTPFNIKLN STEYAELREK
LRAPIRNSPN VVIHQTLSEL FLETFKAQVD LNQPYVLPRG QEVEPCIGCM QVPANTKLVM
LCHEAETDDD DSDCQQCHCR PMWCLLCLGR WFASRLDEQT PETWLSSRVP CPTCRAKFCI
LDVCAVR
//
