ID I3KM68_ORENI Unreviewed; 459 AA.
AC I3KM68;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
GN Name=LOC100704879 {ECO:0000313|Ensembl:ENSONIP00000022213.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000022213.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000022213.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR RefSeq; XP_005468063.2; XM_005468006.3.
DR AlphaFoldDB; I3KM68; -.
DR STRING; 8128.ENSONIP00000022213; -.
DR Ensembl; ENSONIT00000022232.2; ENSONIP00000022213.2; ENSONIG00000017615.2.
DR GeneID; 100704879; -.
DR KEGG; onl:100704879; -.
DR eggNOG; KOG3913; Eukaryota.
DR GeneTree; ENSGT00940000157840; -.
DR HOGENOM; CLU_033039_1_2_1; -.
DR InParanoid; I3KM68; -.
DR OMA; NGIQECK; -.
DR OrthoDB; 2874082at2759; -.
DR TreeFam; TF105310; -.
DR Proteomes; UP000005207; Linkage group LG2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR013301; Wnt8.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF92; PROTEIN WNT-8A; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01892; WNT8PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 459 AA; 51175 MW; 22B0DA995908F834 CRC64;
MHILCINNYH QSLGTTGEFV CVASLKCTYA PTVPICPWEA PANVVDAFHS KMLLAGQICL
SKGARPYKYH ERRVGQQTSV ASFFSWRSHL EYVTLASAWN THAMQPMNFS TVLVLFLCCV
FQLSSAWTMN NFLMTGPKAY LTYASSVQVG AQSGIRECKR QFALEKWNCP ENTRSLSPHN
GLRSATRETS FVHAISAAGV MYTLTKNCTA GDFDNCGCDD SKIGQPGGAG WIWGGCSDNV
AFGEKISKQF VDALEDGHDS RAAVNLHNNE AGRLAIKATM RKACKCHGVS GSCTIQTCWM
QMADFREVGN YLKMKYKHAK ELEMDKKAAR AGNSADNRDA VTHTFLSVAT TELIYLESSP
NYCVKNQTLG LHGTEGRECF KEDKNMSQWE KNSCRRLCNE CGLKVVKKRT EVFTSCNCKF
HWCCTVKCEK CKRVVAKYFC AHKSGKKKNK KGRNSAHQQ
//
