ID I3KN85_ORENI Unreviewed; 2502 AA.
AC I3KN85;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Filamin A, alpha (actin binding protein 280) {ECO:0000313|Ensembl:ENSONIP00000022580.2};
GN Name=FLNA {ECO:0000313|Ensembl:ENSONIP00000022580.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000022580.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000022580.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR STRING; 8128.ENSONIP00000022580; -.
DR Ensembl; ENSONIT00000022600.2; ENSONIP00000022580.2; ENSONIG00000017914.2.
DR GeneTree; ENSGT00940000153588; -.
DR HOGENOM; CLU_000783_0_0_1; -.
DR InParanoid; I3KN85; -.
DR OMA; KWADEHI; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21308; CH_FLNA_rpt1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 23.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537:SF5; FILAMIN-A; 1.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 22.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 22.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 23.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 23.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..148
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 166..269
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 276..374
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 376..474
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 475..571
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 572..664
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 669..765
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 766..868
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 869..967
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 968..1063
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1064..1158
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1159..1258
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1259..1351
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1352..1447
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1448..1544
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1557..1648
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1679..1760
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1760..1852
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1850..1939
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1942..2034
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2032..2130
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2133..2225
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2227..2320
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2324..2416
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2450..2495
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2502 AA; 266433 MW; A97B62CF17D42100 CRC64;
MSGSHPRLHQ SAAPAPNALS ADKDAEMPAT EKDLAEDAPW KKIQQNTFTR WCNEHLKCVN
KRIGNLQTDL SDGLRLIGLL EVLSQKKMFR KYNQRPTFRQ MQLENVSVAL EFLDKENIKL
VSIDSKAIVD GNLKLILGLI WTLILHYSIS MPMWDEEEEA DDGKQKTPKQ RLLGWIQNKL
PELPITNFNR DWQTGRALGA LVDSCAPGLC PDWDQWDQTK PVDNAREAMQ QADDWLGIPQ
VITPEEIVDP NVDEHSVMTY LSQFPKAKLK PGAPLRPKLN PKKARAYGPG VEPVGNVVMK
KATFTVETIS AGMGEVLVYV EDPAGHREEA KVTANNDKNR TYSVVYVPKV TGMHKVTVLF
AGQHISKSPF EVEVGMAQGD SSKATAQGPG LEPSGNIANK STYFDVYTAG AGVGEVEVVI
MDPAGKKNTV TCNIEDKGNS SYRCTYKPTQ EGQHTIYVTF AGGQISKSPF TVNVGEACNP
SLCRAKGRGL QPKGLRVKET ADFKVYTKGA GTGELKVTIK GPKGLEEPCK RKDLGDGVYG
FEYYPTTPGT YSITITWGGQ HIPRSPMEVK IGTEAGQQKV RAWGPGLEGG VVGKSADFVV
EAVGDNVGTL GFSVEGPSQA KIECDDKGDG SCDVRYWPTE PGEYAVHVLC NNEDIQHSPF
MAEIVNPPGK DFYPDKVKAY GPGLQSSGLA VGKPTEFTVD AKQGGKAPLK IVAQDGEGNT
VDVQVKDNGN GTYSCTYTPR KPVKHTVMVS WGDVNIPESP FRMNIGAGCH PNKVKVSGPG
VAKTGLKAFE PTYFTVDCSE AGQGDISIGI KCAPGVVGPA EADIDFDIIR NDNDTFTVKY
TPPGAGSYTI MVLFADQAIP MTPFRVKVDP SHDASKVKAE GPGLSRSGVE LNKPTHFTVS
TKGAGKANLD CNFSGPTKGE AVKDFEIINN HDNTHTVKYT PVQQGPLGVA VTYGGDHIPK
SPFNVGVAPT LDLSKVNVTG LGDKMTVGKD QEVTVKSKGA GGQGKVAAKV TGPGGKPVSS
KVEPGLSPET SQVKFIPREA GPYQVELTYD GVPIPGSPFT PTAYPATDPS KVRCSGPGLE
RAKVGETGEF IVDCTNAGPA ELTIEIISDS GTEAEVHIQD NGDGTYTITY IPLYPGSYTL
TIRYGGQDVP NFPARLNVEP AVDASGVLVF GPGVEGKGVF REATTDFTVD ARALTQTGGD
HIKTHISNPS GSRTDALITD LRDGTYNVEY TPYEEGPHTV EVCYDGSPVP KSPFRVAVTE
GCDPARVRVH GPGLKGGTTN KPNKFTVETR GAGTGGLGLA MEGPSEAKMS CTDNKDGSCS
VEYIPYEPGT YNLNITYGGQ PITGSPFSVP VSDTVDSTKV KCQGPGLGNN VRANIPQAFT
VDASKAGVAP LQVRVQGPKG VVEPVEVVDN GDQTHTVNYV PTREGPYSIN VLYADEEIPR
SPYKVKVLPT HDASKVRASG PGLNTTGVPA SLPVEFTIDA KDAGEGLLAV QITDPEGKPK
KANIRDNHDG TYLVSYVPDM TGRYTILIKY GGDEIPYSPY RIRALPTGDA SKCTVTVSIG
GHGLGAGVGP TIQIGEQTVI TVDAKAAGKG KVTCSVCTPE GAELDVDVVE NEDGTFDIFY
TAPQPGEYVI CVRFGGEHIP NSPFQVTALE GAPSDQLMQQ SQMPQYYTQQ PWATDRPMGM
NGLDVASLRP FDLVIPFTIQ KGEITGEVRM PSGKVAKPDI TDNKDGTVTV KYAPTEAGLH
EMDIKYDGIH IPGSPLQFYV DYMNSGNVSA YGPGLIHGTV NKPAVFTVNT KDAGEGGLSL
AIEGPSKADI SCVDNQDGTC TVSYLPVLPG DYSILVKYND KHIPGSPFSA RITGDDSMRM
SHLKVGSAAD IPLDIGELDL SQLTASLTTP SGREEPCLLK MLRNGHVGIS FVPKEIGEHL
VNIKKNGRHI PSSPISVMIK QSEIGDASRV RVSGPGLSEA RTFEPAEFII DTRDAGYGGL
SLSIEGPSKV DINTEDQEDG TCKVTYCPTE PGNYIINIKF ADQHVPGSAF TVKVTGEGRM
KESITRKKRA ASVANVGSQC DLSLKIPEIS IADMTAQVTS PSGQVHKADI MEGENNTYCI
RFVPTETGVH TVCVKYNGVH VPGSPFQFTV GPLGEGGAHK VRAGGPGLER AEAGVPAEFS
IWTREAGAGG LSIAVEGPSK AEIAFEDRKD GSSGVSYIVQ EPGDYEVSIR FNDEHIPDSP
FIVPVASPSD DARRLTVASL QESGLKVNQP ASFAVSLNGA KGAIDAKVHS PSGALEECCV
TEIDQDKYAV RFIPRENGLY LIDVKFNGSH IPGSPFKIRV GETGQAGDPG MVSAYGPGLE
GGTTGTSCEF VVNTSNAGPG ALAVTIDGPS KVKMDCVECP EGYRVTYTPM APGNYLISIK
YGGPYHIVGS PFKAKITGSK LVSSHSMHET SSVTVDPVTR AISCSQQGTP IQSDASKVVA
KGPGLTKGFI GQKNNFSVDC SKAGRNMLLV ESVAPVLAIH IH
//