ID I3KPH2_ORENI Unreviewed; 1063 AA.
AC I3KPH2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Potassium channel, voltage gated eag related subfamily H, member 7 {ECO:0000313|Ensembl:ENSONIP00000023017.2};
GN Name=KCNH7 {ECO:0000313|Ensembl:ENSONIP00000023017.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023017.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000023017.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; I3KPH2; -.
DR Ensembl; ENSONIT00000023037.2; ENSONIP00000023017.2; ENSONIG00000018281.2.
DR GeneTree; ENSGT00940000155518; -.
DR HOGENOM; CLU_005746_2_0_1; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10217:SF466; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 7; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01470; ERGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 396..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 729..829
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 227..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..999
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1016
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1063 AA; 119431 MW; 8D828D280A8B6DC9 CRC64;
MPVRRGHVAP QNTFLGVIIR KFEGQNKKFI IANARVQNCA IIYCNDGFCE MTGFSRPDVM
QKPCTCDFLH GQFTSRHAVA QVAQALLGSE ERKVEITYHR KDGSNFLCAT HIIPVKNEEG
VVMMFILNFD YILDEGSSDS LERLNHTSPS KADQWKGRFF RFRLPALPLL GISKQSLPQE
DPDAVMVDSP RYSDGSVATR DYQLPTTRES CSPSYANDTR ALIGPSHCST PVSGPLDHSS
PKAPSIPGLT PTVSRESMCS IRRASSVHDM EGFGSNSKMV FRDRHASEGP LSQIKSSLLG
STSDSNLNKY STINKIPLIT LNFSEANNDK KCPSPPSSEK TIIAPKVKDR THNVTDKVTQ
VLSLGADVLP EYKLQTPRMD KWTILHYSPF KAVWDWLILL LVIYTAIFTP YSAAFLLNDI
EEQRRRECGY SCSPLNVVDL IVDIMFIVDI LINFRTTYVN TNEEVVSHPA KIAIHYFKGW
FLIDMVAAIP FDLLIFGSGS DETTTLIGLL KTARLLRLVR VARKLDRYSE YGAAVLMLLM
CIFALIAHWL ACIWYAIGNV EKPYLEHKIG WLDNLGVSIG KKYNYSDPSS GPSIKDKYVT
ALYFTFSSLT SVGFGNVSPN TNSEKIFSIC VMLIGSLMYA SIFGNVSAII QRLYSGTARY
HLQMLRVKEF IRFHQIPNPL RQRLEEYFQH AWTYTNGIDM NMVLKGFPEC LQADICLHLN
KNLLQGCKAF RGATKGCLRA LAMRFKTTHA PPGDTLVHSG DVLTALYFVS RGSIEILKDD
VVVAILGKND IFGEMIHLYA KPGKSCADVR ALSYCDLQTI QREDILEVLD MYPEFADHFF
TNLELTFDLR DENAKIISFA RVCMHIHLCS ARMSFPPELH PNEWVHQHPS EAAEESANCQ
ETAAREDDSD TELTYGEVEQ RLDLLQQHLN RLESQMTADI QAILQLLQRQ TAAGPPAYST
VTSSPEYQRP AVRIQLVSAI DVSPAPPQPQ VQTRFRRGQP SGDIKNKREK TGAEGQKTEQ
IADQIKYLFS SPVIIGFVLK VNIYESSVEI VRESTYMEGQ NLQ
//
