ID I3KQ36_ORENI Unreviewed; 784 AA.
AC I3KQ36;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Semaphorin-4G {ECO:0000313|Ensembl:ENSONIP00000023231.2};
GN Name=SEMA4G {ECO:0000313|Ensembl:ENSONIP00000023231.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023231.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000023231.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; I3KQ36; -.
DR Ensembl; ENSONIT00000023251.2; ENSONIP00000023231.2; ENSONIG00000018453.2.
DR GeneTree; ENSGT00940000157186; -.
DR HOGENOM; CLU_009051_4_2_1; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF17; SEMAPHORIN-4G; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 633..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..480
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 547..603
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 784 AA; 88006 MW; 3F5A3BAE09591DEF CRC64;
IPQQRNPSKK MKFCFTFYLK QSGCRHFQSS AVNYSTMLLE ADSERLYVGA RGAVFALNAS
DISASSALTI DWEASPEQKH QCLLKGKDNK TECFNHIRLL QRFNSTHLYM CGTNAYRPLC
AYIDVERFVI SSQPEEGRDK CPYGPTTGYT ALIIDQQIYT ASQYEFRSFP DIRRNSPSPT
LKTEDAPTRW LNEADFVGSV LVRESVGSSA GDDDKIYFFF TEISQQQTPT YSHSRVARVA
RVCKEDRGGH LTLQKRWTSF LKTRLTCSLP EYDFHFNILR SVFTLPGQTP QDTFFYGIFG
LEWKNVKASA VCRFTLSEVQ EAFQGPYMEN QDSGSKWKEY TGKIPDPRPG TCITDALRAR
NMNFSTSLPD DVLNFVRRHP LMSKQVEPAD RRPLLFRRTT DYTHMGVHTA QGLDGQTYYV
LYMGTDEGWL HKAVDIKGQL HIIEELQLFE EPQPVNNLLI SDKQWSVYMG SPSGVVQLPL
SSCGRYTSCY DCIFARDPHC AWNGAECVDV VMQADRSTLI QDIQHGTEGC ENTQGDVVHR
NRSVRVGDDV LLQCELSSNL ATPLWMLDGR QVQGYDLNSG FRTGTDGLLI IDARQDQSGL
YTCYGVENGV KVAIVTYNVT IRLDLHPPPN MKAIYLSLIT ILGGLCVVLT VVLIYVGFCL
RVGHRGKYSI RAAAALKTIS SHCNGNGICN GGSKMHNGNI QDGGLLQIVP GEGHTSPRCD
FSNGLSATLP SVLRRMHGNS YVLLRQSDSE NMSPPGYSFA EELNKILEKR KRTQLLPRPD
ESSV
//
