ID I3KQC7_ORENI Unreviewed; 1262 AA.
AC I3KQC7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=BK channel {ECO:0000256|ARBA:ARBA00029579};
DE AltName: Full=Slowpoke homolog {ECO:0000256|ARBA:ARBA00033447};
GN Name=KCNMA1 {ECO:0000313|Ensembl:ENSONIP00000023322.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023322.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000023322.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. Calcium-activated
CC (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00008648}.
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DR AlphaFoldDB; I3KQC7; -.
DR Ensembl; ENSONIT00000023342.2; ENSONIP00000023322.2; ENSONIG00000018524.2.
DR GeneTree; ENSGT00940000154935; -.
DR InParanoid; I3KQC7; -.
DR OMA; EANSKFM; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0015269; F:calcium-activated potassium channel activity; IEA:Ensembl.
DR GO; GO:0010996; P:response to auditory stimulus; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048735; Slowpoke-like_C.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF42; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 153..361
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 519..606
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 1030..1150
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1159..1224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1262 AA; 141979 MW; A737B4AA1EDF70A0 CRC64;
MLAEADGTVP HGSDSSMRTS NINNNINPDS SILISRMADV VIPYSSEVPC DNNGQRMWWA
FLASSMVTFF GGLFIILLWR TLKYLWTVCC HCNIKNKEAQ KVNNPANNQA ADRAPKGPDE
KEEAPANEVG WMTSVKDWAG VMISAQTLTG RVLVVLVFAL SIGALGIYFI DSSDPIESCQ
NFYKDFTLQI DMAFNVFFLL YFGLRFIAAN DKLWFWLEVN SVVDFFTVPP VFVSVYLNRS
WLGLRFLRAL RLIQFSEILQ FLNILKTSNS IKLVNLCSIF ISTWLTAAGF IHLVENSGDP
WENFQNSQSL SYWECVYLLM VTMSTVGYGD VYARTTLGRL FMVFFILGGL AMFARYVPEI
AALILNRKKF GGSYNSTRGR KHIVVCGHIT LESVSNFLKD FLHKDRDDVN VEIVFLHNIS
PNLELEALFK RHFTQVEFYQ GSVLNPHDLA RVKIESADAC LILANKYCAD PDAEDASNIM
RVISIKNYHP KIRIITQMLQ YHNKAHLLNI PSWNWKEGDD AICLAELKAG FIAQSCLAQG
LSTMLANLFS MRSFIEIEED TWQKYYLEGV ANEMYTEYLS SAFVGLSFPM VCELCYVKLK
LLLIAIEFKS EQRESSILIN PGNHVKLQEG TLGFFIASDA KEVKRAFFYC KACHDDITDP
KRIKKCGCKR PKMSVYKRMK LACCFDCGRS EQDCSCMSGS VHSNMDTLQR AYPLSSVSVH
DCATTLRAFE DEHPSTLSPK KKQRNGGMRN SPNCSPKMMS RHDPLLIPGN EQIENMDMNV
KRYDSTGMFH WCPSKDIEKV ILTRSEASMT VLSGHVVVCI FGDVTSALVG LRNLVMPLRA
SNFHYHELKP IVFVGSLDYL RREWETLHNF PKVSILPGTP LSRADLRAVN INLCDMCVIL
SANQNNIEDA SLQDKECILA TLNIKSMQFD DSIGVLQANS QGFTPPGMDR SSPDSSPVHG
FVRQASVTTG SNIPIITELV NDSNVQFLDQ DDDDDPDTEL YLTQPFACGT AFAVSVLDSL
MSATYFNDNI LTLIRTLVTG GATPELEALL AEENALRGGY STPQTLANRD RCRVAQLALY
DGPFADLGDG GCYGDLFCKA LKTYNMLCFG IYRLRDAHLG APSQCTKRYV ITNPPYEFEL
VPTDLIFCLM QFDHNAGQSR TSLSHSSHSS HSSSKKSSSV HSIPPSNRQN RSSKTRESRE
KQNATRMNRM GQEKKWFTDE PENAYPRNIQ IKPMSTHMAN QVNQYKSTSS LIPPIREVED
EC
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