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Database: UniProt
Entry: I3KQC7_ORENI
LinkDB: I3KQC7_ORENI
Original site: I3KQC7_ORENI 
ID   I3KQC7_ORENI            Unreviewed;      1096 AA.
AC   I3KQC7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   23-MAY-2018, entry version 40.
DE   SubName: Full=Potassium large conductance calcium-activated channel, subfamily M, alpha member 1a {ECO:0000313|Ensembl:ENSONIP00000023322};
GN   Name=kcnma1 {ECO:0000313|Ensembl:ENSONIP00000023322};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023322, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000023322}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
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DR   EMBL; AERX01027542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSONIT00000023342; ENSONIP00000023322; ENSONIG00000018524.
DR   GeneTree; ENSGT00530000063026; -.
DR   OMA; NRMGQEK; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 1.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028325; VG_K_chnl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10027:SF28; PTHR10027:SF28; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00984201}.
FT   TRANSMEM     20     41       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    107    128       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    144    162       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    174    192       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       14    198       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1096 AA;  123689 MW;  436C1A35DE094516 CRC64;
     LIILSFSSPI ESCQNFYKDF TLQIDMAFNV FFLLYFGLRF IAANDKLWFW LEVNSVVDFF
     TVPPVFVSVY LNRSWLGLRF LRALRLIQFS EILQFLNILK TSNSIKLVNL CSIFISTWLT
     AAGFIHLVEN SGDPWENFQN SQSLSYWECV YLLMVTMSTV GYGDVYARTT LGRLFMVFFI
     LGGLAMFASY VPEIIELIGN RKKYGGSYSA VNGRKHIVVC GHITLESVSN FLKDFLHKDR
     DDVNVEIVFL HNISPNLELE ALFKRHFTQV EFYQGSVLNP HDLARVKIES ADACLILANK
     YCADPDAEDA SNIMRVISIK NYHPKIRIIT QMLQYHNKAH LLNIPSWNWK EGDDAICLAE
     LKAGFIAQSC LAQGLSTMLA NLFSMRSFIE IEEDTWQKYY LEGVANEMYT EYLSSAFVGL
     SFPMVCELCY VKLKLLLIAI EFKSEQRESS ILINPGNHVK LQEGTLGFFI ASDAKEVKRA
     FFYCKACHDD ITDPKRIKKC GCKRPKMSVY KRMKLACCFD CGRSEQDCSC MSGSVHSNMD
     TLQRAYPLSS VSVHDCATTL RAFEDEHPST LSPKKKQRNG GMRNSPNCSP KMMSRHDPLL
     IPGNEQIENM DMNVKRYDST GMFHWCPSKD IEKVILTRSE ASMTVLSGHV VVCIFGDVTS
     ALVGLRNLVM PLRASNFHYH ELKPIVFVGS LDYLRREWET LHNFPKVSIL PGTPLSRADL
     RAVNINLCDM CVILSANQNN IEDASLQDKE CILATLNIKS MQFDDSIGVL QANSQGFTPP
     GMDRSSPDSS PVHGFVRQAS VTTGSNIPII TELVNDSNVQ FLDQDDDDDP DTELYLTQPF
     ACGTAFAVSV LDSLMSATYF NDNILTLIRT LVTGGATPEL EALLAEENAL RGGYSTPQTL
     ANRDRCRVAQ LALYDGPFAD LGDGGCYGDL FCKALKTYNM LCFGIYRLRD AHLGAPSQCT
     KRYVITNPPY EFELVPTDLI FCLMQFDHNA GQSRTSLSHS SHSSHSSSKK SSSVHSIPPS
     NRQNRSSKTR ESREKQNATR MNRMGQEKKW FTDEPENAYP RNIQIKPMST HMANQVNQYK
     STSSLIPPIR EVEDEC
//
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