ID   I3KQT2_ORENI            Unreviewed;       573 AA.
AC   I3KQT2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Disabled homolog 1 {ECO:0000313|Ensembl:ENSONIP00000023477.2};
GN   Name=LOC100693720 {ECO:0000313|Ensembl:ENSONIP00000023477.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023477.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000023477.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_013131863.1; XM_013276409.2.
DR   RefSeq; XP_013131864.1; XM_013276410.2.
DR   RefSeq; XP_019202988.1; XM_019347443.1.
DR   RefSeq; XP_019202989.1; XM_019347444.1.
DR   RefSeq; XP_019202990.1; XM_019347445.1.
DR   AlphaFoldDB; I3KQT2; -.
DR   STRING; 8128.ENSONIP00000023477; -.
DR   Ensembl; ENSONIT00000023498.2; ENSONIP00000023477.2; ENSONIG00000018651.2.
DR   GeneID; 100693720; -.
DR   KEGG; onl:100693720; -.
DR   CTD; 678641; -.
DR   eggNOG; KOG3535; Eukaryota.
DR   GeneTree; ENSGT00940000158038; -.
DR   InParanoid; I3KQT2; -.
DR   OMA; KRHFMTV; -.
DR   OrthoDB; 2913989at2759; -.
DR   TreeFam; TF316724; -.
DR   Proteomes; UP000005207; Linkage group LG18.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   CDD; cd01215; PTB_Dab; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR048559; DAB1/2_SBM.
DR   InterPro; IPR048561; Dab_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   PANTHER; PTHR47695:SF4; DISABLED HOMOLOG 1; 1.
DR   PANTHER; PTHR47695; PID DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF21792; DAB2_SBM; 1.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01179; PID; 1.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          38..170
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          252..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          421..448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          474..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        265..279
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        489..550
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   573 AA;  61502 MW;  43CB0A22CECB2628 CRC64;
     MSAEAELQPG VKTSQRKESR RIKGQDRSEA GLIKRFRGDG VRYKAKLIGI DEVTAARGDK
     LCQDSMMKLK GMASSARSKG EHKQRVFLTV SFGGIKIYCE RSGVLLHHHS VHEISYIAKD
     TRDHRAFGYV CGKEGHHRFV AIKTAQSAEP LIIDLRDLFT LIYDIKQREE MEKKAQKDKQ
     CEQAVYQTIL EDEVDDPVYQ YIVFEAGHEP LRGPQSEESV YQVPTSQQKE GIYDVPKRHF
     MTNINHFDLF GDMSTPPSMP PSPANTLDPS RSSRQQQHTP AELYAPFSPT SVPSGYMTMG
     PVQAAQWAQQ PFPAQAQTLA FPVQAPLQVA QVLPSGQPVI WSQANIFPAT QQQWAAMAAY
     MPAQTVGVGG HAIPAAMLQG LVPITTMCPQ ACDLSAPSSA ITSPQHTADP TLLQKQLSLG
     KEGLDSDAGE GPSTSGAAVS VEPGGVSAGV SRCGTPGLMS VPDTLACSQL LPPPAAATQE
     EEGSCSDLDL SRMTLSPGTS TSPSTESPST PAPQQSSSSD CPPSQGSDPP TDHSPVDPEG
     NSSNAKEEQL GSAVVPSEAA DPPQDQTCPQ EDS
//