ID I3KRC9_ORENI Unreviewed; 406 AA.
AC I3KRC9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Ribonucleoside-diphosphate reductase subunit M2 {ECO:0000256|ARBA:ARBA00040401};
DE EC=1.17.4.1 {ECO:0000256|ARBA:ARBA00012274};
DE AltName: Full=Ribonucleotide reductase small chain {ECO:0000256|ARBA:ARBA00042512};
GN Name=RRM2 {ECO:0000313|Ensembl:ENSONIP00000023674.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023674.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000023674.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase small
CC chain family. {ECO:0000256|ARBA:ARBA00009303}.
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DR AlphaFoldDB; I3KRC9; -.
DR STRING; 8128.ENSONIP00000023674; -.
DR Ensembl; ENSONIT00000023695.2; ENSONIP00000023674.2; ENSONIG00000018804.2.
DR eggNOG; KOG1567; Eukaryota.
DR GeneTree; ENSGT00390000013305; -.
DR HOGENOM; CLU_035339_0_1_1; -.
DR OMA; WIANESK; -.
DR TreeFam; TF300465; -.
DR Proteomes; UP000005207; Linkage group LG15.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:InterPro.
DR CDD; cd01049; RNRR2; 1.
DR Gene3D; 1.10.620.20; Ribonucleotide Reductase, subunit A; 1.
DR InterPro; IPR009078; Ferritin-like_SF.
DR InterPro; IPR012348; RNR-like.
DR InterPro; IPR033909; RNR_small.
DR InterPro; IPR030475; RNR_small_AS.
DR InterPro; IPR000358; RNR_small_fam.
DR PANTHER; PTHR23409; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN; 1.
DR PANTHER; PTHR23409:SF20; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2; 1.
DR Pfam; PF00268; Ribonuc_red_sm; 1.
DR SUPFAM; SSF47240; Ferritin-like; 1.
DR PROSITE; PS00368; RIBORED_SMALL; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 242..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 406 AA; 46931 MW; E6DDBBB1572CDCB2 CRC64;
MRKTKLKVCI QRLKPAQIKV TMLSARSPLS MKNEQTLSGQ LDKISLDKEN TPPGLNSSRI
LASKTARRIF DAAAPKVKKS SSSQEEEPLL KENPRRFVIF PIKYHDIWQM YKKAEASFWT
AEEVDLSKDL QHWEALKDEE RYFISHVLAF FAASDGIVNE NLVERFMQEV QVTEARCFYG
FQIAMENIHS EMYSLLIDTY IKDPKEREYL FNAIETLPCV KKKADWALNW IGNKNATYGE
RVVAFAAVEG IFFSGSFAAI FWLKKRGLMP GLTFSNELIS RDEVRRCDFA CLMFKHLLNK
PPKETVISII KNAVEIEQEF LTDALPVKLI GMNCDMMKQY IEFVADRLLL ELGFSKIYRV
ENPFDFMENI SLEGKTNFFE KRVGEYQRMG VMAAPTDNTF RLDADF
//
