ID   I3KRE1_ORENI            Unreviewed;       678 AA.
AC   I3KRE1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Cleavage and polyadenylation specificity factor subunit 3 {ECO:0000313|Ensembl:ENSONIP00000023686.2};
GN   Name=LOC100692710 {ECO:0000313|Ensembl:ENSONIP00000023686.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023686.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000023686.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; I3KRE1; -.
DR   STRING; 8128.ENSONIP00000066919; -.
DR   Ensembl; ENSONIT00000023707.2; ENSONIP00000023686.2; ENSONIG00000018812.2.
DR   eggNOG; KOG1137; Eukaryota.
DR   GeneTree; ENSGT00940000155699; -.
DR   HOGENOM; CLU_009673_2_3_1; -.
DR   TreeFam; TF105643; -.
DR   Proteomes; UP000005207; Linkage group LG15.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd16292; CPSF3-like_MBL-fold; 1.
DR   Gene3D; 3.40.50.10890; -; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR021718; CPSF73-100_C.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   PANTHER; PTHR11203; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER; 1.
DR   PANTHER; PTHR11203:SF11; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3; 1.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF11718; CPSF73-100_C; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM01098; CPSF73-100_C; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          31..217
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
FT   DOMAIN          253..374
FT                   /note="Beta-Casp"
FT                   /evidence="ECO:0000259|SMART:SM01027"
FT   DOMAIN          484..676
FT                   /note="Pre-mRNA 3'-end-processing endonuclease
FT                   polyadenylation factor C-term"
FT                   /evidence="ECO:0000259|SMART:SM01098"
SQ   SEQUENCE   678 AA;  76600 MW;  609774D68961CBC1 CRC64;
     MAAKRKPEAT VPAEESDQLL IRPLGAGQEV GRSCIILEFK GRKIMLDCGI HPGLEGMDAL
     PYIDLIDPAE IDLLLISHFH LDHCGALPWF LQKTSFKGRT FMTHATKAIY RWLLSDYVKV
     SNISADDMLY TETDLEDSME KIETINFHEV KEVAGIKFWC YHAGHVLGAA MFMIEIAGVK
     LLYTGDFSRQ EDRHLMAAEI PSVKPDILIT ESTYGTHIHE KREEREARFC NTVHDIVNRE
     GRCLIPVFAL GRAQELLLIL DEYWQNHPEL HDIPIYYASS LARKCMAVYQ TYINAMNDKI
     RKAININNPF VFKHISNLKS MDHFDDIGPS VVMASPGMMQ SGLSRELFES WCTDRRNGVI
     IAGYCVEGTL AKHIMTEPDE ITTMSGQKLP LKMSVDYISF SAHTDYQQTS EFIRALKPPH
     VILVHGEQNE MARLKAALIR EYEDNDEVHI EVHNPRNTEA VTLNFRGEKL AKVMGSLADK
     KCIQGQRVSG ILVKRNFNYH ILAPSDLSNY TDLSMGMVTQ TQAIPYTGPI SLLVSQLRNL
     SGDVEQVEGT EKITVRIFKS ITMVHEASMV LLEWIANPLN DMYADAVTTV ILEVQSNPNA
     QKFVEGKKES FDMDVFVERL ALMLHDMFGD DCVNFKDGKN LSVTVDGVTA SVDPETRDHF
     VLNSQTSCYR MGYDPICT
//