ID I3KS33_ORENI Unreviewed; 780 AA.
AC I3KS33;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Transferrin receptor 2 {ECO:0000313|Ensembl:ENSONIP00000023929.2};
GN Name=tfr2 {ECO:0000313|Ensembl:ENSONIP00000023929.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023929.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000023929.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013123214.1; XM_013267760.2.
DR AlphaFoldDB; I3KS33; -.
DR STRING; 8128.ENSONIP00000052856; -.
DR Ensembl; ENSONIT00000023950.2; ENSONIP00000023929.2; ENSONIG00000019005.2.
DR GeneID; 100692777; -.
DR KEGG; onl:100692777; -.
DR CTD; 7036; -.
DR eggNOG; KOG2195; Eukaryota.
DR GeneTree; ENSGT01030000234598; -.
DR HOGENOM; CLU_005688_5_0_1; -.
DR OrthoDB; 2428249at2759; -.
DR TreeFam; TF312981; -.
DR Proteomes; UP000005207; Linkage group LG3.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004998; F:transferrin receptor activity; IEA:InterPro.
DR GO; GO:0033572; P:transferrin transport; IEA:InterPro.
DR CDD; cd09848; M28_TfR; 1.
DR CDD; cd02128; PA_TfR; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR InterPro; IPR037324; TfR1/2_PA.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR PANTHER; PTHR10404:SF33; TRANSFERRIN RECEPTOR PROTEIN 2; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 66..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 224..290
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 399..590
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 85863 MW; A42E113FFB2A5D9C CRC64;
MTTHLTQASL MSVHHSVSDD DEEEEVGGAQ RAELRLAISE DEEEAGPFSD LTALVMRYRH
GYRRCCVLLC VGGVIVFTAA FLLAYGIFSG RYHCSQAEQG HEQQLGGAKA PSEGGAGLYL
GELRLMMRKL LQDEDIHNTV SRVSRAAHPP GSSEGTALAS EILQRFRDLQ MDHTWTESLY
ATLQFPDRSQ RSSLSLVDSA GWVSEQIPLN PSDYCPYSAT GNATGGVVYA NYGRPEDFKW
LKREDVSVTG CVVVMRVGGG VSFAEKVWLA EKNGASGALI YPDPADVPQD PRRLGLNTHT
AVSEHVHLGS GDPFTPGFPS FNHTQFPPIQ SSGLPLIPAL PITATVASKL LSQLTGPSCP
RPWQGRLPYV RCVVGPEFSN GRRVQMSVQN VMKPILLNNI FSSLEGRVEP DQYIILGAQR
DSLGPGAVKS GVGTAILLEL ARTFSAMVKK GFSPRRSLLF VSWDAGDFGN VGATEWLEGY
LSMLHLKAVA YFSLDQAVMG DEILSAYTSP LLVDLLDAAI RQVEHPKHAG QSIYSQAERD
GGSWRIMKPL YLNSGAFSFT AFAGVPAMEL RFTEERAYPF INTPLDSVSR LQEVLGGRLG
VTGRSLGELV GEMVLRLAHD HILPLRITSY AQTVLQFSAQ LNKHSAELQS RGLSPQWVFS
ARGDYSRAAE TLQRAIDYSD LHEPTITRFY NTRIMKVEYY FLSQYVSAVE TPFRHVIHGR
GNHTLSALTE HLGLLTSDPG RFDESSFRRQ LALFTWTLQG AANALNGDVW SIHNMHRFTH
//
