ID I3KS47_ORENI Unreviewed; 972 AA.
AC I3KS47;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023943.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Ensembl:ENSONIP00000023943.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR AlphaFoldDB; I3KS47; -.
DR Ensembl; ENSONIT00000023964.2; ENSONIP00000023943.2; ENSONIG00000031002.1.
DR eggNOG; ENOG502QS9E; Eukaryota.
DR GeneTree; ENSGT01100000263487; -.
DR OMA; ESSYITH; -.
DR TreeFam; TF352120; -.
DR Proteomes; UP000005207; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 8.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 13..106
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 204..338
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 972 AA; 108599 MW; 82DF174E7420CF17 CRC64;
MMKEPVEEPP IKEASSAAEE LATVRTEFVS RVSTEILTQL LEALVTTHVF NDLEKRRILE
GNPVTADRAR CTIDIVINKG NKASRIMISH LCTKDPCLWS ELCLSSDQQR LLKYTLKNCQ
PGLKSKLRKK FQCVFEGIAK AGNPTLLNQI YTELYITEGG TAEVNDEHEV RQIETASRKP
DRPETTIRQE DIFKASPGRD EPIRTVLTKG VAGIGKTVLT QKYTLDWAED KANQDIQFIF
PFTFRELNVL KEEKFSLVEL VHHFFTETKE AGICSFEDFQ VVFIFDGLDE CRLPLDFHKT
TILTDPRKST SVDVLLINLI RGKLLPSARL WITTRPAAAN HIPPDCVGMV TEVRGFTDPQ
KEEYFKKRFR DAEQANRIIS HIKTSRSLHI MCHIPVFCWI TATVLGDVLE TREGGQLPKT
LTEMYIHFLV VQAKVKKVKY DGGAETDPHW NKTNRKMIKS LGKLAFDQLQ KGNLIFYESD
LTECGIDIRA ASVYSGVFTQ IFKEERGLYQ DKVFCFIHLS VQEFLAALRV HLTFINSGVN
LLEEQQVKLW SKLFKKKISL KSVHQSAVNK AIQSPNGHLD LFLRFLLGLS LQTNQTLLRG
LLTQTGSSSQ TNQETVQYIK EKLSENLSAE KSINLFHCLN ELNDRSLVEE IQQSLRSGRL
STDKLSPAQW SALVFILLSS EKDLDVFDLK KYSASEEALL RLLPVVKASN KALLSSCNLS
EEGCEVLLSV VSSQSCSLRE LDLSTNSLKA SAVKLLSAAV ESPHAKLNVL RLNICELSEE
NCEALSSVLS SQSSGLTELD LSIRKLQDSG VKLLSAGLQR LNCKLNTLRL SGCNLSERSC
EALSSVLSSQ SSSLRELDLS NSDLQDSGVK LLSAGLKSSQ CAVETLSLSG CLITEEGCTS
LASALSSNPS HLRELDLSYN HPGDSGTKLL SAGLKDPGWR LDTLRYGECL IDEEELETFP
VSFPHFLFVS CR
//
