ID   I3KSH6_ORENI            Unreviewed;       343 AA.
AC   I3KSH6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Renalase, FAD dependent amine oxidase {ECO:0000313|Ensembl:ENSONIP00000024072.1};
GN   Name=rnls {ECO:0000313|Ensembl:ENSONIP00000024072.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024072.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000024072.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_013129415.1; XM_013273961.2.
DR   AlphaFoldDB; I3KSH6; -.
DR   STRING; 8128.ENSONIP00000024072; -.
DR   Ensembl; ENSONIT00000024093.2; ENSONIP00000024072.1; ENSONIG00000019125.2.
DR   GeneID; 100700836; -.
DR   CTD; 55328; -.
DR   eggNOG; ENOG502QUZR; Eukaryota.
DR   GeneTree; ENSGT00390000016052; -.
DR   HOGENOM; CLU_036034_1_0_1; -.
DR   InParanoid; I3KSH6; -.
DR   OMA; ICGGDAF; -.
DR   OrthoDB; 5394503at2759; -.
DR   TreeFam; TF332799; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR   Gene3D; 3.90.660.10; -; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR040174; RNLS.
DR   PANTHER; PTHR23357:SF1; RENALASE; 1.
DR   PANTHER; PTHR23357; UNCHARACTERIZED; 1.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   Pfam; PF13450; NAD_binding_8; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..343
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003674207"
FT   DOMAIN          86..332
FT                   /note="Amine oxidase"
FT                   /evidence="ECO:0000259|Pfam:PF01593"
SQ   SEQUENCE   343 AA;  37542 MW;  E428A05BB184590B CRC64;
     MSRVLIVGAG LTGSLCACLL RRELQSTVRI VVWDKARGAG GRMSTSRAPD ASSQSADLGA
     QYISATPAYA RSHHRFYSEL LSAGLLQPLD CLIEGLKDHE GTENYVTPLG TSSIIKHFLS
     QSGADLFLEH HMTGLYRRGA SWEVERKAGA SEMFDAVVLT MPVPQILQLQ GDLGQLLSVQ
     QRQQLEGVVY SSRFALALFF SPDAILNVPW GAKYVTDSSC IRYVAVDSKK RGADAPGRGP
     SLVVHTSVPF GLEHLERDKE DVQPIILREL HRLLPGLPQP INIKCQKWRY SQVQTSVPDC
     PGHMTILDEP LLVCGGDAFT HSNFDGCVES ALSMLRVLKA KFA
//