ID   I3KSQ6_ORENI            Unreviewed;       610 AA.
AC   I3KSQ6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024152.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000024152.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3KSQ6; -.
DR   Ensembl; ENSONIT00000024173.2; ENSONIP00000024152.2; ENSONIG00000019187.2.
DR   eggNOG; ENOG502QS9E; Eukaryota.
DR   GeneTree; ENSGT01100000263513; -.
DR   HOGENOM; CLU_002274_3_0_1; -.
DR   InParanoid; I3KSQ6; -.
DR   OMA; KYDPHWS; -.
DR   TreeFam; TF352120; -.
DR   Proteomes; UP000005207; Linkage group LG23.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SMART; SM01288; FISNA; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          107..241
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   610 AA;  69939 MW;  4D591A9D0D684D84 CRC64;
     MRRKKQGKLA DCLHRKHLVT VCPRKLKSKL KKKFQCVFEG IAKAGNPTLL NQIYTELYIT
     EGGTAEVNDE HELRQIETVS RKPDRPETTI RQEDIFKASP GRDKPIRTVL TKGVAGIGKT
     LLTQKFTLDW AKDKANQDIQ FIFPFPFREL NVLKEEKFSL VELVHHFFTE TKKAGICSFE
     DFQVVFIFDG LDECRLPLDF HKNEILTDPR KPTSVDVLLT NLIRGYLLPS ARIWITTRPA
     AANQIPPQCV DMVTEIRGFT DPQMEEYFRK RSRDEEQGSR IISHIKTSQS LYIMCHIPVF
     CWITATVLED VLETREGRQL PKTLTETYIH FLVVQAKMRK VKYDPHWSPE SRRMIESLGK
     LSFDQLQKGN LIFYESDLTE CGIDIIAASI YSGVFTQIFR EERVLYQEKV FCFTHLSVQE
     FLAALHVHLT FINSGVNVLE EQQTTSQKFK RSQSFDMLIL IQSAVDKALQ SPNGHLDLFL
     RFFLGLSLQT NQTLLRGLLT QTGSSSQTNR ETVQYIKEKL SENLSAEKSI NLLHCLNELN
     DCSLVEEIQQ SLRSGSFSTD ELSPAQWSAL VFILLSSEKD LDVFDLKKFS ASEEALLRLL
     PVVKASNKAL
//