ID I3KSU2_ORENI Unreviewed; 578 AA.
AC I3KSU2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Amino acid transporter {ECO:0000256|RuleBase:RU361216};
GN Name=slc1a7 {ECO:0000313|Ensembl:ENSONIP00000024188.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024188.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000024188.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361216}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000256|RuleBase:RU361216}.
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DR RefSeq; XP_003444344.1; XM_003444296.4.
DR AlphaFoldDB; I3KSU2; -.
DR STRING; 8128.ENSONIP00000024188; -.
DR Ensembl; ENSONIT00000024209.2; ENSONIP00000024188.1; ENSONIG00000019216.2.
DR GeneID; 100698133; -.
DR KEGG; onl:100698133; -.
DR CTD; 100463517; -.
DR eggNOG; KOG3787; Eukaryota.
DR GeneTree; ENSGT00940000156073; -.
DR HOGENOM; CLU_019375_3_2_1; -.
DR InParanoid; I3KSU2; -.
DR OrthoDB; 49426at2759; -.
DR TreeFam; TF315206; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:1902475; P:L-alpha-amino acid transmembrane transport; IEA:UniProt.
DR Gene3D; 1.10.3860.10; Sodium:dicarboxylate symporter; 1.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR11958:SF22; EXCITATORY AMINO ACID TRANSPORTER 5; 1.
DR PANTHER; PTHR11958; SODIUM/DICARBOXYLATE SYMPORTER-RELATED; 1.
DR Pfam; PF00375; SDF; 1.
DR PRINTS; PR00173; EDTRNSPORT.
DR SUPFAM; SSF118215; Proton glutamate symport protein; 1.
DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361216};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|RuleBase:RU361216};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361216};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361216};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361216}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 97..116
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 224..241
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 261..286
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 298..324
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 336..361
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 373..398
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 410..439
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
SQ SEQUENCE 578 AA; 63081 MW; D0140BB95EF5C7B8 CRC64;
MAMALDAVWV RVKNVCKQNG LLIMSVMAVV IGCLLGFFLR TRRLTEQEVK YFQFPGELLM
RMLKMLILPL VVSSLMSGLA ALDAKCSSRL GLITVSYYLW TTFVAVIVGI IMVSIIHPGG
AAQKEDSEDS GKPIMSSADA LLDLIRNMFP ANLVQATFQQ YRTSSEYIVK PRPTVRQAQA
ESTTRRALVY GIQDDNGTDI QNFALDLTPP PDVLIRTREG TSDGMNVLGI VIFSATMGIM
LGRMGPNGSA LVNFCQSLNE AVLRIVAIVI WYFPFGIVFL VAGKILEMSD PSAMGKKLGF
YAVTVVFGLV LHGLFILPAM YFFITKKSPI VYIRGILQAL LIALATSSSS ATLPITFKCL
LENNHIDRRI IRFVLPVGAT INMDGTALYE AVAAIFIAQV NNYELDFGQI ITISITATAA
SIGAAGIPQA GLVTMVIVLT SVGLPTDDIT LIIAVDWALD RFRTMVNVMG DALATGIMAH
ICRKDFMKEG DGVPLICETK TAMSTPPVMN CHNNNGNCRP PPLGVKHQFI PPEVAQLIQL
EEGVRPLSDR KKPPIPPRHL KKSKEHCTID MNGLETNV
//
