ID I3KT50_ORENI Unreviewed; 625 AA.
AC I3KT50;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO2A1 {ECO:0000313|Ensembl:ENSONIP00000024296.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024296.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000024296.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; I3KT50; -.
DR STRING; 8128.ENSONIP00000080786; -.
DR Ensembl; ENSONIT00000024317.2; ENSONIP00000024296.2; ENSONIG00000019304.2.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01080000257336; -.
DR HOGENOM; CLU_008954_4_1_1; -.
DR TreeFam; TF317540; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF14; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..625
FT /note="Solute carrier organic anion transporter family
FT member"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025517212"
FT TRANSMEM 74..95
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 173..194
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 227..249
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 286..310
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 330..351
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 475..492
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 512..537
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 566..586
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 400..470
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 625 AA; 69319 MW; 4B1CAB6305FAE460 CRC64;
MFPVSPLFVL CHGLLQLSQL LYSAYFKSTI STIERRYGLS SYSSGTISSL HEVSNCILIV
FVSYFGNRVH RPRIIGVGGL LMAISAMMLT LPHFLSQPYE YGSVLHNRHD MCNLQSTSNS
TQSCNRDETR RLTDTNNLWL LMASAQLLFG VGSVPIQPYG ISYIDDFAGP ANSPLYIAIL
FAVSVFGPAF GYLLGSAMLR VYVDVNIKDL GETALQLRPG DPRWIGAWWM GLLISTGCLV
LTSIPYFFFP RTMASQDHVT RSESGSEDED SLLGFLKSFP KKFVDLLLSP LFLILVLAQC
CFSSVIAGLA TFLNKYLERQ YATTAAYANL LFGSVNLPFV AVGMLAGGVI MKRVGLSLKA
IPRFAVVMLT ISTLFCIPLF WMGCSTQKVS EVNHFQSSQS WSPPSCYSNC NCPNSTFNPV
CSYDGIEYIS PCHAGCTNFT KDPDNPYRIG EYTNCSCTAS TKAKSGPCEN GCPHFLHPVI
IIISLASLIA CLTHNPMYMM VLRSVPSDEK SFAIGIQFLL MRLLAWLPAP ALFGMAIDTS
CLRWRTICEK KFSCGYYDNN MLRNRYLGLQ VGYKVMGIVL LMILGWKVHR TEEYSLADDK
KDHSDCPAEK QGDPNLLKLC CGVKR
//
