ID I3KTJ6_ORENI Unreviewed; 461 AA.
AC I3KTJ6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF1 {ECO:0000256|ARBA:ARBA00016876};
DE AltName: Full=Ezrin-radixin-moesin-binding phosphoprotein 50 {ECO:0000256|ARBA:ARBA00032844};
DE AltName: Full=Regulatory cofactor of Na(+)/H(+) exchanger {ECO:0000256|ARBA:ARBA00032825};
DE AltName: Full=Sodium-hydrogen exchanger regulatory factor 1 {ECO:0000256|ARBA:ARBA00030310};
DE AltName: Full=Solute carrier family 9 isoform A3 regulatory factor 1 {ECO:0000256|ARBA:ARBA00033293};
GN Name=NHERF1 {ECO:0000313|Ensembl:ENSONIP00000024442.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024442.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000024442.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cell projection, microvillus
CC {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}.
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DR RefSeq; XP_005468358.1; XM_005468301.3.
DR AlphaFoldDB; I3KTJ6; -.
DR STRING; 8128.ENSONIP00000024442; -.
DR Ensembl; ENSONIT00000024463.2; ENSONIP00000024442.2; ENSONIG00000019417.2.
DR GeneID; 100706235; -.
DR KEGG; onl:100706235; -.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00950000182849; -.
DR HOGENOM; CLU_038627_1_0_1; -.
DR InParanoid; I3KTJ6; -.
DR OMA; ERESHQQ; -.
DR OrthoDB; 2914289at2759; -.
DR TreeFam; TF350449; -.
DR Proteomes; UP000005207; Linkage group LG4.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 2.
DR InterPro; IPR015098; EBP50_C.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14191:SF7; NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF1; 1.
DR PANTHER; PTHR14191; PDZ DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF09007; EBP50_C; 1.
DR Pfam; PF00595; PDZ; 2.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR PROSITE; PS50106; PDZ; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 18..98
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 263..343
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 125..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..220
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 51128 MW; BF34F203B983D5B2 CRC64;
MRVKPNMPSK SQYLRPRLCT LEKGDNGYGF HLHGEKGKTG QFIRLVEPDS PAETSGLRAG
DRLVYVNGED VENESHQQVV SRIRATVGRL ELIVVDPDTE QLLKKHNLKC LKAFVTDGVP
LPFEEEEEEE VVVVEKEEEE EEKKKEEGEV VVEEKQEDGE VNGTENGDEP REEEVVEEVK
QEETPEETPE ETTPEETPEE TTPEETPEET TPEETPEETP EETPRESTPI PATNGQIHGH
VEKKLSISSE KEQEVRAELR PRLCVIQRGT SGYGFNLHSE RARPGQYIRA VDEDSPAERA
GLLPKDRIVE VNSMSVEGKT HSDVVAAIKA GGHEARLLVV DPETDAFFKR CRVTPTSEHL
TGPLPEPVVN GGMEEKVNGS MAKEATRDSK VSVSPSPSNA SSNASLTTPP ANTPPEGAIT
DAIPALNLTL QQVKELAHRK RSNKRAPPMD WTKKNELFSN L
//
